Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Christopher W J Smith"'
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 11, p e1001016 (2010)
The branch point (BP) is one of the three obligatory signals required for pre-mRNA splicing. In mammals, the degeneracy of the motif combined with the lack of a large set of experimentally verified BPs complicates the task of modeling it in silico, a
Externí odkaz:
https://doaj.org/article/c0e60278c15542e58e298e6ea04b5cdd
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1801 (2008)
The frequency of synonymous codon usage varies widely between organisms. Suboptimal codon content limits expression of viral, experimental or therapeutic heterologous proteins due to limiting cognate tRNAs. Codon content is therefore often adjusted t
Externí odkaz:
https://doaj.org/article/adfedb7974e84cbba789dd18ffdc0715
Autor:
Vanessa D’Angeli, Elisa Monzón-Casanova, Louise S. Matheson, Özge Gizlenci, Georg Petkau, Clare Gooding, Rebecca V. Berrens, Christopher W. J. Smith, Martin Turner
Publikováno v:
European Journal of Immunology. 52:1058-1068
The RNA-binding protein polypyrimidine tract binding protein 1 (PTBP1) has been found to have roles in CD4 T-cell activation, but its function in CD8 T cells remains untested. We show it is dispensable for the development of naïve mouse CD8 T cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6177636ea190a0e34eb80d74763e8212
https://doi.org/10.1002/eji.202149781
https://doi.org/10.1002/eji.202149781
Phosphorylation of the smooth muscle master splicing regulator RBPMS regulates its splicing activity
Autor:
Michael D Barnhart, Yi Yang, Erick E Nakagaki-Silva, Thomas H Hammond, Mariavittoria Pizzinga, Clare Gooding, Katherine Stott, Christopher W J Smith
Funder: United States Air Force
We previously identified RBPMS as a master regulator of alternative splicing in differentiated smooth muscle cells (SMCs). RBPMS is transcriptionally downregulated during SMC dedifferentiation, but we hypothesized
We previously identified RBPMS as a master regulator of alternative splicing in differentiated smooth muscle cells (SMCs). RBPMS is transcriptionally downregulated during SMC dedifferentiation, but we hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e02223f23a5669d61ef368c756705f
https://www.repository.cam.ac.uk/handle/1810/342090
https://www.repository.cam.ac.uk/handle/1810/342090
Autor:
Li Liu, Dmytro Kryvokhyzha, Catarina Rippe, Aishwarya Jacob, Andrea Borreguero-Muñoz, Karin G. Stenkula, Ola Hansson, Christopher W. J. Smith, Steven A. Fisher, Karl Swärd
Funder: Lund University
Differentiation of smooth muscle cells (SMCs) depends on serum response factor (SRF) and its co-activator myocardin (MYOCD). The role of MYOCD for the SMC program of gene transcription is well established. In contrast, th
Differentiation of smooth muscle cells (SMCs) depends on serum response factor (SRF) and its co-activator myocardin (MYOCD). The role of MYOCD for the SMC program of gene transcription is well established. In contrast, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa58f53075d8b5591e2d2224fc687742
https://www.repository.cam.ac.uk/handle/1810/340334
https://www.repository.cam.ac.uk/handle/1810/340334
Publikováno v:
Nature reviews. Genetics. 23(11)
A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms. Alternative splicing generates multiple transcripts from a single gene, enriching the diversity of protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbb7bde84c818cdb80caf0fffeea05ff
https://pubmed.ncbi.nlm.nih.gov/35821097
https://pubmed.ncbi.nlm.nih.gov/35821097
Autor:
null Vanessa D'Angeli, null Elisa Monzón‐Casanova, null Louise S. Matheson, null Özge Gizlenci, null Georg Petkau, null Clare Gooding, null Rebecca V. Berrens, null Christopher W. J. Smith, null Martin Turner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b2140cf08aefb50350ca4671c26ca7
https://doi.org/10.1002/eji.202149781/v3/response1
https://doi.org/10.1002/eji.202149781/v3/response1
Autor:
Michael Briese, Nejc Haberman, Christopher R. Sibley, Rupert Faraway, Andrea S. Elser, Anob M. Chakrabarti, Zhen Wang, Julian König, David Perera, Vihandha O. Wickramasinghe, Ashok R. Venkitaraman, Nicholas M. Luscombe, Luciano Saieva, Livio Pellizzoni, Christopher W. J. Smith, Tomaž Curk, Jernej Ule
Publikováno v:
Nature Structural & Molecular Biology. 28:455-455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fbb15c9b8d4de2b187105bb5b7bb671
https://doi.org/10.1038/s41594-021-00595-5
https://doi.org/10.1038/s41594-021-00595-5
Publikováno v:
Pediatric Hematology and Oncology. 31:386-388
Neonatal thrombosis is associated with infection, inflammation, impaired liver function, congenital heart disease, inherited thrombophilia, and in particular the use of intravascular catheters [1–3...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9a101729d4f9bedaa5e48cff6587cd9
https://doi.org/10.3109/08880018.2013.879969
https://doi.org/10.3109/08880018.2013.879969