Zobrazeno 1 - 10 of 102 pro vyhledávání: '"Christopher W Dawson"'
1
Akademický článek
The EBV-Encoded Oncoprotein, LMP1, Recruits and Transforms Fibroblasts via an ERK-MAPK-Dependent Mechanism
Autor: Alexandra M Davis, Abigail Rapley, Christopher W Dawson, Lawrence S Young, Mhairi A Morris
Publikováno v: Pathogens, Vol 10, Iss 8, p 982 (2021)
Latent membrane protein 1 (LMP1), the major oncoprotein encoded by Epstein–Barr virus (EBV), is expressed at widely variable levels in undifferentiated nasopharyngeal carcinoma (NPC) biopsies, fueling intense debate in the field as to the importanc
Externí odkaz: https://doaj.org/article/54bcc61173264b23a1c6febb51fccc33
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2
Akademický článek
A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels.
Autor: Chunfang Hu, Wenbin Wei, Xiaoyi Chen, Ciaran B Woodman, Yunhong Yao, John M Nicholls, Irène Joab, Sim K Sihota, Jian-Yong Shao, K Dalia Derkaoui, Aicha Amari, Stephanie L Maloney, Andrew I Bell, Paul G Murray, Christopher W Dawson, Lawrence S Young, John R Arrand
Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41055 (2012)
Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesi
Externí odkaz: https://doaj.org/article/8f662a7d54aa4ae18f6d06c5d45f7c40
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3
Akademický článek
Aberrant activation of the Hedgehog signalling pathway in squamous cell carcinoma of the vulva as a potential target for cancer therapy
Autor: Jason K. W. Yap, Khalil Uddin, Rachel Pounds, Danielle O’Neill, Sean Kehoe, Raji Ganesan, Christopher W. Dawson
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract In a previous study, we showed that the Hedgehog (Hh) signalling pathway is aberrantly activated in vulval squamous cell carcinoma (VSCC). In this study, we further validated our findings on a prospective cohort of primary VSCC cases, where
Externí odkaz: https://doaj.org/article/05f946613f6a40b3894bfa1218318429
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4
Akademický článek
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
Autor: Jeff P. Bruce, Ka-Fai To, Vivian W. Y. Lui, Grace T. Y. Chung, Yuk-Yu Chan, Chi Man Tsang, Kevin Y. Yip, Brigette B. Y. Ma, John K. S. Woo, Edwin P. Hui, Michael K. F. Mak, Sau-Dan Lee, Chit Chow, Sharmila Velapasamy, Yvonne Y. Y. Or, Pui Kei Siu, Samah El Ghamrasni, Stephenie Prokopec, Man Wu, Johnny S. H. Kwan, Yuchen Liu, Jason Y. K. Chan, C. Andrew van Hasselt, Lawrence S. Young, Christopher W. Dawson, Ian C. Paterson, Lee-Fah Yap, Sai-Wah Tsao, Fei-Fei Liu, Anthony T. C. Chan, Trevor J. Pugh, Kwok-Wai Lo
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activ
Externí odkaz: https://doaj.org/article/84b65b92c11446b886dec64811b68199
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6
Akademický článek
The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy
Autor: Angela Kwok-Fung Lo, Christopher W. Dawson, Hong Lok Lung, Ka-Leung Wong, Lawrence S. Young
Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an import
Externí odkaz: https://doaj.org/article/4850ee0319144e15be9bba972cb65b41
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