Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher W Bakerlee"'
Publikováno v:
eLife, Vol 10 (2021)
Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of s
Externí odkaz:
https://doaj.org/article/11f5bf11feae423aa676a36ecff8e924
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
AbstractSpontaneous whole-genome duplication, or autodiploidization, is a common route to adaptation in experimental evolution of haploid budding yeast populations. The rate at which autodiploids fix in these populations appears to vary across strain
Externí odkaz:
https://doaj.org/article/e73d00b0cd99414984a50258f831af30
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations
Autor:
Milo S Johnson, Shreyas Gopalakrishnan, Juhee Goyal, Megan E Dillingham, Christopher W Bakerlee, Parris T Humphrey, Tanush Jagdish, Elizabeth R Jerison, Katya Kosheleva, Katherine R Lawrence, Jiseon Min, Alief Moulana, Angela M Phillips, Julia C Piper, Ramya Purkanti, Artur Rego-Costa, Michael J McDonald, Alex N Nguyen Ba, Michael M Desai
Publikováno v:
eLife, Vol 10 (2021)
Laboratory experimental evolution provides a window into the details of the evolutionary process. To investigate the consequences of long-term adaptation, we evolved 205 Saccharomyces cerevisiae populations (124 haploid and 81 diploid) for ~10,000 ge
Externí odkaz:
https://doaj.org/article/e8d8f2f76fba43eeaf3f7eae82f045e8
Autor:
Oliver M. Crook, Kelsey Lane Warmbrod, Greg Lipstein, Christine Chung, Christopher W. Bakerlee, T. Greg McKelvey, Shelly R. Holland, Jacob L. Swett, Kevin M. Esvelt, Ethan C. Alley, William J. Bradshaw
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Identifying the designers of engineered biological sequences would help promote biotechnological innovation while holding designers accountable. Here the authors present the winners of a 2020 data-science competition which improved on previous attemp
Externí odkaz:
https://doaj.org/article/0f3e4593fa454b63b132992866454ef3
Autor:
Christopher W. Bakerlee, Alex N. Nguyen Ba, Yekaterina Shulgina, Jose I. Rojas Echenique, Michael M. Desai
Publikováno v:
Science
Epistasis can markedly affect evolutionary trajectories. In recent decades, protein-level fitness landscapes have revealed extensive idiosyncratic epistasis among specific mutations. By contrast, other work has found ubiquitous and apparently nonspec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2b5d69eae4355a89f1ea73b078db52
https://europepmc.org/articles/PMC10124986/
https://europepmc.org/articles/PMC10124986/
Autor:
Josh Morrison, David Manheim, Nicholas Joseph, T. Greg McKelvey, Derek Foster, Alexander J Norman, Conor F Barnes, Steven Jiang, Megan Kinniment, Thomas C. Darton, Christopher W Bakerlee, Sophie M Rose, Linh Chi Nguyen, Michael R. McLaren
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases
Clinical Infectious Diseases
Human challenge trials (HCTs) have been proposed as a means to accelerate SARS-CoV-2 vaccine development. We identify and discuss 3 potential use cases of HCTs in the current pandemic: evaluating efficacy, converging on correlates of protection, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f41103878761d4bf89a7885b421d9dc
https://doi.org/10.1093/cid/ciaa935
https://doi.org/10.1093/cid/ciaa935
Autor:
Oliver M. Crook, Kelsey Lane Warmbrod, Greg Lipstein, Christine Chung, Christopher W. Bakerlee, T. Greg McKelvey, Shelly R. Holland, Jacob L. Swett, Kevin M. Esvelt, Ethan C. Alley, William J. Bradshaw
The ability to identify the designer of engineered biological sequences -- termed genetic engineering attribution (GEA) -- would help ensure due credit for biotechnological innovation, while holding designers accountable to the communities they affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba23621ddfe3bdd38172acd86b34151a
http://arxiv.org/abs/2110.11242
http://arxiv.org/abs/2110.11242
Autor:
Yekaterina Shulgina, Christopher W Bakerlee, J. I. Rojas-Echenique, A. N. Nguyen Ba, Michael M. Desai
Epistasis can dramatically affect evolutionary trajectories. In recent decades, protein-level fitness landscapes have revealed extensive idiosyncratic epistasis among specific mutations. In contrast, other work has found ubiquitous and apparently non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb16cefb8ba8e3609cc0f0c3c2aff83c
https://doi.org/10.1101/2021.09.22.461382
https://doi.org/10.1101/2021.09.22.461382
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations
Autor:
Shreyas Gopalakrishnan, Julia C Piper, Christopher W Bakerlee, Michael M. Desai, Parris T. Humphrey, Jiseon Min, Elizabeth R. Jerison, Tanush Jagdish, Milo S Johnson, Michael J. McDonald, Megan E Dillingham, Juhee Goyal, Ramya Purkanti, Katya Kosheleva, Angela M Phillips, Alex N. Nguyen Ba, Artur Rego-Costa, Katherine R. Lawrence, Alief Moulana
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Laboratory experimental evolution provides a window into the details of the evolutionary process. To investigate the consequences of long-term adaptation, we evolved 205 Saccharomyces cerevisiae populations (124 haploid and 81 diploid) for ~10,000 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8499cfee2a0dd1ecd9db0b51f30d5b25
https://elifesciences.org/articles/63910
https://elifesciences.org/articles/63910