Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Autor: Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin, Uzi Gileadi, Salvatore Valvo, Margarida Rei, Corinna Kulicke, Ji-Li Chen, Vitul Jain, Victoria K. Woodcock, Huw Colin-York, Andreas V. Hadjinicolaou, Youxin Kong, Viveka Mayya, Julie M. Mazet, Gracie-Jennah Mead, Joshua A. Bull, Pramila Rijal, Christopher W. Pugh, Alain R. Townsend, Audrey Gérard, Lars R. Olsen, Marco Fritzsche, Tudor A. Fulga, Michael L. Dustin, E. Yvonne Jones, Vincenzo Cerundolo

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not completely

Externí odkaz: https://doaj.org/article/0037fd20318049ccb1e0d08f25e77331

Lung Ultrasound Reproducibly Outperforms Computed Tomography in the Detection of Extravascular Lung Water in Patients Undergoing Haemodialysis

Autor: John P. Corcoran, Mark Hew, Ben Attwood, Murali Shyamsundar, Sheera Sutherland, Kristine Ventura, Rachel Benamore, Victoria St. Noble, Hania E. Piotrowska, Christopher W. Pugh, Christian B. Laursen, Fergus V. Gleeson, Najib M. Rahman

Publikováno v: Diagnostics, Vol 14, Iss 6, p 589 (2024)

Background: Lung ultrasound (LUS) is increasingly used as an extension of physical examination, informing clinical diagnosis, and decision making. There is particular interest in the assessment of patients with pulmonary congestion and extravascular

Externí odkaz: https://doaj.org/article/1207bec70b02449ba59b12c17ed32b6e

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Autor: Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley

Publikováno v: Mirchandani, A S, Jenkins, S J, Bain, C C, Sanchez Garcia, M A, Lawson, H, Coelho, P, Murphy, F, Griffith, D, Zhang, A, Morrison, T, Ly, T, Arienti, S, Sadiku, P, Watts, E R, Dickinson, R, Reyes, L, Cooper, G, Clark, S, Lewis, D, Kelly, V, Spanos, C, Musgrave, K M, Delaney, L, Harper, I, Scott, J, Parkinson, N, Rostron, A J, Baillie, J K, Clohisey, S, Pridans, C, Campana, L, Starkey Lewis, P, Simpson, A J, Dockrell, D H, Schwarze, J, Hirani, N, Ratcliffe, P J, Pugh, C W, Kranc, K, Forbes, S J, Whyte, M K B & Walmsley, S R 2022, ' Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation ', Nature Immunology . https://doi.org/0.1038/s41590-022-01216-z

Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab39b51379ba91e60afdc26dc1fbd1
https://doi.org/10.1038/s41590-022-01216-z

Supplementary Figure 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Autor: Patrick J. Pollard, Ian Tomlinson, Mona El-Bahrawy, Lauri Aaltonen, Virpi Launonen, Michael I. Kotlikoff, Maria Flavia Di Renzo, Chiara Bardella, Barbara Costa, Christopher W. Pugh, Richard Poulsom, Gordon Stamp, Patrick H. Maxwell, Emanuela Volpi, Mohammed Yusuf, Bradley Spencer-Dene, John Griffiths, Helen Troy, Deepa Shukla, Kimberley Howarth, Melroy Miranda, Emine Hatipoglu, Emma Nye, Heli Lehtonen, Sakari Vanharanta, Phil East, Yuen-Li Chung, Violetta Steeples, Julie Adam, Linda O'Flaherty, Houman Ashrafian

Supplementary Figure 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66bd17812622d75cdee182e67af7c11
https://doi.org/10.1158/0008-5472.22385856.v1

Supplementary Table 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Autor: Patrick J. Pollard, Ian Tomlinson, Mona El-Bahrawy, Lauri Aaltonen, Virpi Launonen, Michael I. Kotlikoff, Maria Flavia Di Renzo, Chiara Bardella, Barbara Costa, Christopher W. Pugh, Richard Poulsom, Gordon Stamp, Patrick H. Maxwell, Emanuela Volpi, Mohammed Yusuf, Bradley Spencer-Dene, John Griffiths, Helen Troy, Deepa Shukla, Kimberley Howarth, Melroy Miranda, Emine Hatipoglu, Emma Nye, Heli Lehtonen, Sakari Vanharanta, Phil East, Yuen-Li Chung, Violetta Steeples, Julie Adam, Linda O'Flaherty, Houman Ashrafian

Supplementary Table 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250f89d56f3c21259d6311a83c7ffbc3
https://doi.org/10.1158/0008-5472.22385847