Výsledky vyhledávání - "Christopher Thomas Evans"

Akademický článek

Visualisation of microalgal-viral interactions by high-speed atomic force microscopy

Autor: Christopher Thomas Evans, Oliver Payton, Loren Picco, Michael J. Allen

Publikováno v: Frontiers in Virology, Vol 3 (2023)

Visualization of viruses and their hosts has been paramount to their study and understanding. The direct observation of the morphological dynamics of infection is a highly desired capability and the focus of instrument development across a variety of

Externí odkaz: https://doaj.org/article/2ca9955b29bc4ac79e779e14bfe9c200

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Development of the biocatalytic resolution of 2-azabicyclo[2.2.1]hept-5-en-3-one as an entry to single-enantiomer carbocyclic nucleosides

Autor: Stephen J.C. Taylor, Fergal O'Brien, Jennifer A. Littlechild, Raymond Mccague, Karen Dickson, Wisdom Richard Anthony, Jennifer Bevan, Stanley M. Roberts, Graham Ruecroft, Carol Lee, Christopher Thomas Evans

Publikováno v: Tetrahedron: Asymmetry. 4:1117-1128

For the resolution of the bicyclic lactam 2-azabicyclo[2.2.1]hept-5-en-3-one, efficient whole cell biocatalysts have been identified and from these, enzymes (lactamases) have been isolated. While the two enzymes obtained act on different enantiomers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::886a250be07e0aa798000a2d87483304
https://doi.org/10.1016/s0957-4166(00)80218-9

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ChemInform Abstract: Synthesis of Either Enantiomer of cis-3-Aminocyclopentanecarboxylic Acid from Both Enantiomers of Racemic 2-Azabicyclo(2.2.1)hept-5-en-3- one

Autor: Raymond Mccague, Christopher Thomas Evans, Alan G. Sutherland, Stanley M. Roberts

Publikováno v: ChemInform. 22

(–)-2-Azabicyclo[2.2.1]hept-5-en-3-one (–)-1 was converted into (–)-cis-3-aminocyclopentanecarboxylic acid (–)-2 in two steps and into the enantiomeric amino-acid (+)-2 in three steps.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc939e3944d3e8c04ba88086f57b87e7
https://doi.org/10.1002/chin.199125124

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ChemInform Abstract: Potential Use of Carbocyclic Nucleosides for the Treatment of AIDS: Chemo-Enzymatic Syntheses of the Enantiomers of Carbovir

Autor: Christopher Thomas Evans, Stanley M. Roberts, Alan G. Sutherland, Karoline A. Shoberu

Publikováno v: ChemInform. 23

The lactam (1R),(4S)-2-azabicyclo[2.2.1]hept-5-en-3-one [(–)-2], derived by whole cell enantio-specific hydrolysis of the racemate was converted into (–)-carbovir (–)-1 in ten steps. Lipase catalysed acetylation of 4-cis-hydroxycyclopent-2-enyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2db1fb7bfacc77ebde75251a89f52d4b
https://doi.org/10.1002/chin.199224255

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ChemInform Abstract: Development of the Biocatalytic Resolution of 2-Azabicyclo(2.2.1)hept- 5-en-3-one as an Entry to Single-Enantiomer Carbocyclic Nucleosides

Autor: Graham Ruecroft, Fergal O'Brien, Wisdom Richard Anthony, Carol Lee, Christopher Thomas Evans, Jennifer A. Littlechild, Stanley M. Roberts, Karen Dickson, Raymond Mccague, Stephen J.C. Taylor, Jennifer Bevan

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32eb71b0e9cc38020fda09bd81e4eb0b
https://doi.org/10.1002/chin.199341272

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Chemoenzymatic synthesis of (–)-carbovir utilizing a whole cell catalysed resolution of 2-azabicyclo[2.2.1]hept-5-en-3-one

Autor: Carol Lee, Wisdom Richard Anthony, Alan G. Sutherland, Stanley M. Roberts, Steven J. C. Taylor, Christopher Thomas Evans, Steve Thomas

Publikováno v: J. Chem. Soc., Chem. Commun.. :1120-1121

The resolution of (±)-2-azabicyclo[2.2.1]hept-5-en-3-one (3), a versatile intermediate in the synthesis of carbocyclic nucleosides, is described; both optical forms of the lactam have been obtained in very high optical purity (> 98% enantiomeric exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a4599b53740ef532ffff5a07ad7ce8b
https://doi.org/10.1039/c39900001120

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Potential use of carbocyclic nucleosides for the treatment of AIDS: chemo-enzymatic syntheses of the enantiomers of carbovir

Autor: Karoline A. Shoberu, Alan G. Sutherland, Christopher Thomas Evans, Stanley M. Roberts

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :589

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15818de7c8efd95f25d5582c8792b621
https://doi.org/10.1039/p19920000589

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