Výsledky vyhledávání - "Christopher T. Szlenk"

Akademický článek

Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor

Autor: Sabrina Fechtner, Anil K. Singh, Ila Srivastava, Christopher T. Szlenk, Tim R. Muench, Senthil Natesan, Salahuddin Ahmed

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Management of pain in the treatment of rheumatoid arthritis (RA) is a priority that is not fully addressed by the conventional therapies. In the present study, we evaluated the efficacy of cannabinoid receptor 2 (CB2) agonist JWH-015 using RA synovia

Externí odkaz: https://doaj.org/article/95384f265754403eba37a156a176735f

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Allosteric modulation of α1β3γ2 GABAA receptors by farnesol through the neurosteroid sites

Autor: Jeevan B. GC, Christopher T. Szlenk, Ayobami Diyaolu, Peter Obi, Haiyang Wei, Xutong Shi, K. Michael Gibson, Senthil Natesan, Jean-Baptiste Roullet

Publikováno v: Biophysical Journal. 122:849-867

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de8ae794956928b44ea0ccbb41f53e6a
https://doi.org/10.1016/j.bpj.2023.01.032

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Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-Acting β2-Adrenergic Receptor Agonists

Autor: Senthil Natesan, Christopher T. Szlenk, Jeevan B. Gc

Publikováno v: Molecular Pharmacology. 100:406-427

The drugs salmeterol, formoterol, and salbutamol constitute the frontline treatment of asthma and other chronic pulmonary diseases. These drugs activate the β2-adrenergic receptors (β2-AR), a class A G protein–coupled receptor (GPCR), and differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ad7c92bec06b9836e49263f13a47b02
https://doi.org/10.1124/molpharm.121.000285

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Engaging Scientists in Policy Discourse

Autor: Priyanka N. Bushana, Christopher T. Szlenk, Shannon Kozlovich

Publikováno v: Curr Protoc Essent Lab Tech

Today’s science is largely funded by taxpayer dollars, and because of this, scientists have a responsibility to ensure that their research is being effectively communicated back to taxpayers and to the policy makers who determine the distribution o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5600cb06369bbe6abe319daccfc62c91
https://pubmed.ncbi.nlm.nih.gov/35765515

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Molecular Dynamics Simulations Provide Insight into the Loading Efficiency of Proresolving Lipid Mediators Resolvin D1 and D2 in Cell Membrane-Derived Nanovesicles

Autor: Jin Gao, Senthil Natesan, Zhenjia Wang, Jeevan B. Gc, Christopher T. Szlenk, Xinyue Dong

Publikováno v: Mol Pharm

Resolvins D1 and D2 (RvDs) are structural isomers and metabolites of docosahexaenoic acid, an omega-3 fatty acid, enzymatically produced in our body in response to acute inflammation or microbial invasion. Resolvins have been shown to play an essenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370fe118d5529b5d7b88a329d2200d4b
https://doi.org/10.1021/acs.molpharmaceut.0c00299

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Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?

Autor: Christopher T. Szlenk, Senthil Natesan, Jeevan B. Gc

Publikováno v: Mol Pharmacol

The ligand-binding sites of many G protein-coupled receptors (GPCRs) are situated around and deeply embedded within the central pocket formed by their seven transmembrane-spanning α-helical domains. Generally, these binding sites are assumed accessi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3923aa03a36ab01e443ecfb240c06083
https://doi.org/10.1124/mol.118.115113

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