Výsledky vyhledávání - "Christopher T. Privalle"

Multicenter, Randomized, Placebo-Controlled Phase III Study of Pyridoxalated Hemoglobin Polyoxyethylene in Distributive Shock (PHOENIX)*

Autor: Andreas Meier-Hellmann, Joseph DeAngelo, Harald Darius, Erwin Boehm, Christopher T. Privalle, Mervyn Singer, José A. Lorente, Ricard Ferrer, Gernot Marx, Jean Louis Vincent, J.M. Sirvent

Publikováno v: Critical Care Medicine. 43:57-64

To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene, against placebo in patients with vasopressor-dependent distributive shock.Multicenter, randomized, placebo-controlled, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef52fd9e18dc3acdbb1988722a4fdf64
https://doi.org/10.1097/ccm.0000000000000554

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Pyridoxalated hemoglobin polyoxyethylene: a nitric oxide scavenger with antioxidant activity for the treatment of nitric oxide-induced shock

Autor: Joseph DeAngelo, Todd L. Talarico, Teresa Keng, Christopher T. Privalle

Publikováno v: Free radical biologymedicine. 28(10)

Hemoglobins modified for therapeutic use as either hemoglobin-based oxygen carriers or scavengers of nitric oxide are currently being evaluated in clinical trials. One such product, pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), is a human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f76705e2ef32bb229ffed4c06e81341
https://pubmed.ncbi.nlm.nih.gov/10927175

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Production, purification, and characterization of recombinant human hemoglobin rainier expressed in Saccharomyces cerevisiae

Autor: Veronica Nwosu, Christopher T. Privalle, Sanjay Jain, Nalini M. Motwani, Michael J. Holland, Todd L. Talarico, Wajeeh Bajwa, Joseph DeAngelo, Robert Blackburn, Teresa Keng

Publikováno v: Protein expression and purification. 8(4)

Hemoglobin Rainier is a naturally occurring hemoglobin variant in which the beta 145 tyrosine is substituted with cysteine. The alpha and beta Rainier globin cDNAs were cloned in a high copy number vector and expressed in Saccharomyces cerevisiae und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca0ae1a9a619c19a214f0f48ba356a2
https://pubmed.ncbi.nlm.nih.gov/8954892

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Nitrosative stress: activation of the transcription factor OxyR

Autor: Jonathan S. Stamler, Joseph DeAngelo, Teresa Keng, Christopher T. Privalle, Alfred Hausladen

Publikováno v: Cell. 86(5)

Hydrogen peroxide (H 2 O 2 ) imposes an oxidative stress to Escherichia coli that is manifested by oxidation of glutathione and related redox-sensitive targets. OxyR is a thiol-containing transcriptional activator whose oxidation controls the express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367e7e4bea17c05e59cb02a3c857e7ed
https://pubmed.ncbi.nlm.nih.gov/8797819

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Induction of manganese-containing superoxide dismutase in anaerobic Escherichia coli by diamide and 1,10-phenanthroline: sites of transcriptional regulation

Autor: Stephanie E. Kong, Irwin Fridovich, Christopher T. Privalle

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 90(6)

Transcriptional regulation of the sodA gene, a member of the soxRS regulon encoding the manganese-containing superoxide dismutase (MnSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) of Escherichia coli, was examined in a variety of regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1401e46bec7f5eea60233ebb5f936790
https://pubmed.ncbi.nlm.nih.gov/8460139

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Anaerobic inductions of active forms of superoxide dismutases in Escherichia coli

Autor: Christopher T. Privalle, Irwin Fridovich

Publikováno v: Free radical research communications.

Escherichia coli growing anaerobically respond to NO3- with a approximately 3-fold induction of active FeSOD and a approximately 5.5-fold induction of an inactive, but activatable form of MnSOD (pro-MnSOD). Paraquat, which mediates anaerobic electron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0924dee3f657d341cb1c8d67c99fdbaa
https://pubmed.ncbi.nlm.nih.gov/2071046

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