Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christopher T. Poll"'
Membrane capacitance and conductance changes parallel mucin secretion in the human airway epithelium
Autor:
Christopher T. Poll, Hazel C. Atherton, James L. Kreindler, Alan D. Jackson, Henry Danahay, Robert J. Bridges
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L558-L569
Measurement of the magnitude and kinetics of exocytosis from intact epithelia has historically been difficult. Using well-differentiated cultures of human bronchial epithelial cells, we describe the use of transepithelial impedance analysis to enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32829d29a15f1ddcb193616ffb0fbcf1
https://doi.org/10.1152/ajplung.00351.2005
https://doi.org/10.1152/ajplung.00351.2005
Publikováno v:
British Journal of Pharmacology. 143:91-98
1. Receptor-mediated calcium entry (RMCE) was examined in well-differentiated cultures of normal human bronchial epithelial cells (HBECs). Changes in intracellular free Ca(2+) ([Ca(2+)](i)) were quantified using fluorescence ratio imaging of Fura-2-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f359806ef34858ddc2e06c6235c8f5aa
https://doi.org/10.1038/sj.bjp.0705913
https://doi.org/10.1038/sj.bjp.0705913
Autor:
Robert J. Bridges, Christian L. Laboisse, Christopher T. Poll, Henry Danahay, Ulrich Hopfer, Carol A. Bertrand
Publikováno v:
American Journal of Physiology-Cell Physiology. 286:C247-C255
ATP is an efficacious secretagogue for mucin and chloride in the epithelial cell line HT29-Cl.16E. Mucin release has been measured as [3H]glucosamine-labeled product in extracellular medium and as single-cell membrane capacitance increases indicative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f2ca173459d696c6d61b600d3c67ef
https://doi.org/10.1152/ajpcell.00593.2002
https://doi.org/10.1152/ajpcell.00593.2002
Autor:
Parmjit Bahra, Christopher T. Poll, Louise E. Donnelly, Mariana Oana Popa, Onn Min Kon, Gabor Jarai, Andrew G. Nicholson, Su Li, John Westwick, Richard Russell, Tricia Finney-Hayward, Peter J. Barnes, Martin Gosling
Publikováno v:
American journal of respiratory cell and molecular biology. 43(3)
Chronic obstructive pulmonary disease (COPD) is associated with pulmonary inflammation with increased numbers of macrophages located in the parenchyma. These macrophages have the capacity to mediate the underlying pathophysiology of COPD; therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b63c8fe250b9d48d9466b6d833f8d25
https://pubmed.ncbi.nlm.nih.gov/19843708
https://pubmed.ncbi.nlm.nih.gov/19843708
Publikováno v:
American journal of respiratory cell and molecular biology. 43(2)
Chronic obstructive pulmonary disease (COPD) involves disease of small airways with an increase in airway smooth muscle sensitivity to spasmogens and with structural changes described as airway remodeling. We investigated the effect of tobacco smoke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81b07bb7cf54296ec65e209fb953855
https://pubmed.ncbi.nlm.nih.gov/19783789
https://pubmed.ncbi.nlm.nih.gov/19783789
Autor:
P. J. Barnes, Andrew G. Nicholson, John Westwick, Richard Russell, Louise E. Donnelly, Peter Fenwick, Parmjit Bahra, Tricia Finney-Hayward, S. Li, Christopher T. Poll, Paul Ford
Publikováno v:
The European respiratory journal. 33(5)
Increased numbers of macrophages and neutrophils in the lung is a key feature of chronic obstructive pulmonary disease (COPD). The major neutrophil chemotactic agent in the airways of COPD patients is leukotriene (LT)B(4) and is released by macrophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6b5b07ad47ff97fb890ac3d21dbf82
https://pubmed.ncbi.nlm.nih.gov/19164358
https://pubmed.ncbi.nlm.nih.gov/19164358
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 367(2)
Interleukin (IL)-13 (10 ng/ml for 48 h) treatment of human bronchial epithelial cells induced a hypersecretory ion transport phenotype. Ussing chamber experiments demonstrated that this phenotypic change was characterised by an almost complete inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ab8e1b71887532c24aea21d9073bb2
https://pubmed.ncbi.nlm.nih.gov/12595965
https://pubmed.ncbi.nlm.nih.gov/12595965
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 282(2)
Interleukin (IL)-13 has been associated with asthma, allergic rhinitis, and chronic sinusitis, all conditions where an imbalance in epithelial fluid secretion and absorption could impact upon the disease. We have investigated the effects of IL-13 on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f53432c2f5b77b8147cef6b318f96e
https://pubmed.ncbi.nlm.nih.gov/11792627
https://pubmed.ncbi.nlm.nih.gov/11792627
Publikováno v:
American journal of physiology. Cell physiology. 280(6)
A cytoprotective role for protease-activated receptor-2 (PAR2) has been suggested in a number of systems including the airway, and to this end, we have studied the role that PARs play in the regulation of airway ion transport, using cultures of norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9193ab6c2ca5d6818a8dd111d2fd55d9
https://pubmed.ncbi.nlm.nih.gov/11350741
https://pubmed.ncbi.nlm.nih.gov/11350741
Autor:
Sara Dodd, Jane B. Leithead, Graham A. Place, Nicola J. Jordan, Suzanna Grix, Christopher T. Poll, John Westwick, Teizo Yoshimura, Malcolm L. Watson
Publikováno v:
Cytokine. 10(5)
Leukocyte accumulation and activation are key events in the pathogenesis of inflammatory lung disease. The ability of human airway smooth muscle cells (HASM) to contribute to the inflammatory process by its ability to produce the chemokines interleuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fd973aa950b06845e026d5f18b2976
https://pubmed.ncbi.nlm.nih.gov/9619372
https://pubmed.ncbi.nlm.nih.gov/9619372