Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher T. John"'
Autor:
Rebecca M. Klein, Mark E. Layton, Hillary Regan, Christopher P. Regan, Yuxing Li, Tracey Filzen, Matt Cato, Michelle K. Clements, Jixin Wang, Raul Sanoja, Thomas J. Greshock, Anthony J. Roecker, Joseph E. Pero, Ron Kim, Christopher Burgey, Christopher T. John, Ying-Hong Wang, Neetesh Bhandari, Arie Struyk, Richard L. Kraus, Darrell A. Henze, Andrea K. Houghton
Publikováno v:
Channels, Vol 16, Iss 1, Pp 230-243 (2022)
As part of a drug discovery effort to identify potent inhibitors of NaV1.7 for the treatment of pain, we observed that inhibitors produced unexpected cardiovascular and respiratory effects in vivo. Specifically, inhibitors administered to rodents pro
Externí odkaz:
https://doaj.org/article/55057518620746559c951066d12dfcf1
Autor:
Gregory L. Adams, Parul S. Pall, Steven M. Grauer, Xiaoping Zhou, Jeanine E. Ballard, Marissa Vavrek, Richard L. Kraus, Pierre Morissette, Nianyu Li, Stefania Colarusso, Elisabetta Bianchi, Anandan Palani, Rebecca Klein, Christopher T. John, Deping Wang, Matthew Tudor, Andrew F. Nolting, Mirlinda Biba, Timothy Nowak, Alexey A. Makarov, Mikhail Reibarkh, Alexei V. Buevich, Wendy Zhong, Erik L. Regalado, Xiao Wang, Qi Gao, Aurash Shahripour, Yuping Zhu, Daniele de Simone, Tommaso Frattarelli, Nicolo’ Maria Pasquini, Paola Magotti, Roberto Iaccarino, Yuxing Li, Kelli Solly, Keun-Joong Lee, Weixun Wang, Feifei Chen, Haoyu Zeng, Jixin Wang, Hilary Regan, Rupesh P. Amin, Christopher P. Regan, Christopher S. Burgey, Darrell A. Henze, Chengzao Sun, David M. Tellers
Publikováno v:
Journal of Medicinal Chemistry. 65:485-496
Autor:
Tony W. Ng, Wakako Furuyama, Ariel S. Wirchnianski, Noemí A. Saavedra-Ávila, Christopher T. Johndrow, Kartik Chandran, William R. Jacobs, Andrea Marzi, Steven A. Porcelli
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Previous studies have demonstrated the efficacy and feasibility of an anti-viral vaccine strategy that takes advantage of pre-existing CD4+ helper T (Th) cells induced by Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccination. This strategy u
Externí odkaz:
https://doaj.org/article/f8873c18c52a478ba7ece8617e9ee5b6
Autor:
Amy C. Doty, Seth P. Forster, Christopher T. John, Wei Xu, Daniel Skomski, Ryan S. Teller, Stephanie E. Barrett, Yongchao Su, Zhen Liu
Publikováno v:
Journal of pharmaceutical sciences. 109(9)
In pharmaceutical development alternative drug delivery modalities are being increasingly employed. One example is an implant, which achieves gradual drug release in patients over a period of many months or years. Due to the complexity of these long-
Autor:
Ronald L. Smith, Benjamin Figueroa, Christopher T. John, Tai Nguyen, Timothy Rhodes, Yongchao Su, Matthew S. Lamm, Sutthilug Sotthivirat, Wei Xu, Dan Fu
Publikováno v:
Analytical chemistry. 91(10)
It has been estimated that approximately 50% of all marketed drug molecules are manufactured and administered in the form of salts, often with the goal of improving solubility, dissolution rate, and efficacy of the drug. However, salt disproportionat
Autor:
Patrick J. Marsac, Lynne S. Taylor, Stephen R. Byrn, Christopher T. John, Jie Ren, Wei Xu, Haichen Nie
Publikováno v:
Molecular Pharmaceutics. 13:3541-3552
Excipient-induced salt disproportionation (conversion from salt form to free form) in the solid state during storage or manufacturing is a severe formulation issue that can negatively influence product performance. However, the role of excipient prop
Autor:
Paul J. Coleman, Becky Nissley, Allen C. Templeton, Yunhui Wu, Rosa I. Sanchez, Jaume Balsells, Jay A. Grobler, Sophie-Dorothee Clas, Michael J. Hafey, Junying Wang, Abbas Walji, Qun Dang, Rebecca Nofsinger, Jing Li, Manuel de Lera Ruiz, Gene Chessen, John M. Sanders, Christopher T. John, Amrithraj Bennet, John S. Wai, David Jonathan Bennett, Kimberly Manser, Christina N. Di Marco, Scott S. Ceglia, Somang Hope Kim, John Higgins, Ronald D. Smith
Publikováno v:
ChemMedChem. 10:245-252
Developing new antiretroviral therapies for HIV-1 infection with potential for less frequent dosing represents an important goal within drug discovery. Herein, we present the discovery of ethyl (1-((4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(5-meth
Publikováno v:
Pharmaceutical Research. 30:1628-1641
Nine common excipients were examined to determine their ability to cause disproportionation of the HCl salt of a a weakly basic compound. The goal was to determine which excipients were problematic and correlate the results to known properties such a
Autor:
Jesse L. Kuiper, James D. Ormes, Annette Bak, Christopher T. John, Grace A. Ilevbare, Wei Xu, Allen C. Templeton
Publikováno v:
Pharmaceutical Sciences Encyclopedia
This chapter presents differences between dispersions, amorphous materials, and crystalline forms, and discusses the impact of excipient selection, especially polymers. It provides guidance for solubility and dissolution testing of amorphous dispersi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::733dfb601dea15d0beeab6ed2742e379
https://doi.org/10.1002/9780470571224.pse527
https://doi.org/10.1002/9780470571224.pse527
Autor:
Ben P. Diaz, Ben Knowles, Christopher T. Johns, Christien P. Laber, Karen Grace V. Bondoc, Liti Haramaty, Frank Natale, Elizabeth L. Harvey, Sasha J. Kramer, Luis M. Bolaños, Daniel P. Lowenstein, Helen F. Fredricks, Jason Graff, Toby K. Westberry, Kristina D. A. Mojica, Nils Haëntjens, Nicholas Baetge, Peter Gaube, Emmanuel Boss, Craig A. Carlson, Michael J. Behrenfeld, Benjamin A. S. Van Mooy, Kay D. Bidle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Phytoplankton are important primary producers. Here the authors investigate phytoplankton physiological changes associated with bloom phases and mixing regimes in the North Atlantic, finding that stratification and deep mixing shape accumulation rate
Externí odkaz:
https://doaj.org/article/44a4e944f1064afeb7d83d06350c825b