Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Christopher T Jones"'
Autor:
Margaret A Scull, William M Schneider, Brenna R Flatley, Robert Hayden, Canny Fung, Christopher T Jones, Marieke van de Belt, François Penin, Charles M Rice
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005297 (2015)
The hepatitis C virus (HCV) p7 protein is required for infectious virus production via its role in assembly and ion channel activity. Although NMR structures of p7 have been reported, the location of secondary structural elements and orientation of t
Externí odkaz:
https://doaj.org/article/8e98e42c107d473fa2317db2b1406289
Autor:
John Lok Man Law, Chao Chen, Jason Wong, Darren Hockman, Deanna M Santer, Sharon E Frey, Robert B Belshe, Takaji Wakita, Jens Bukh, Christopher T Jones, Charles M Rice, Sergio Abrignani, D Lorne Tyrrell, Michael Houghton
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59776 (2013)
Although a cure for HCV is on the near horizon, emerging drug cocktails will be expensive, associated with side-effects and resistance making a global vaccine an urgent priority given the estimated high incidence of infection around the world. Due to
Externí odkaz:
https://doaj.org/article/79f80c8f3d334a15841ec258bb18caa6
Publikováno v:
Biology & Philosophy. 38
In recent years, the explanatory term “scaffold” has been gaining prominence in evolutionary biology. This notion has a long history in other areas, in particular, developmental psychology. In this paper, we connect these two traditions and ident
Publikováno v:
Systematic Biology. 69:722-738
A central objective in biology is to link adaptive evolution in a gene to structural and/or functional phenotypic novelties. Yet most analytic methods make inferences mainly from either phenotypic data or genetic data alone. A small number of models
Publikováno v:
J Neurosci
Neuronal diversity provides the spinal cord with the functional flexibility required to perform complex motor tasks. Spinal neurons arise during early embryonic development with the establishment of spatially and molecularly discrete progenitor domai
Autor:
Erin Quirk, Feng Jin, Pengfei Guo, Daria B. Crittenden, Yujin Wang, Christopher T. Jones, Martijn Fenaux, Michael Charlton, Kevin Klucher, Clarence Eng, Qiong Zhang, Diana Chung
Publikováno v:
Clinical pharmacology in drug developmentReferences. 10(10)
TERN-101 is a nonsteroidal farnesoid X-receptor agonist being developed for the treatment of nonalcoholic steatohepatitis (NASH). We assessed the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of TERN-101 capsule and tablet formulations in
Autor:
Edward Susko, Timothy M. Lenton, Celso Neto, Christopher T. Jones, W. Ford Doolittle, Joseph P. Bielawski, Letitia Meynell
In most multispecies multilevel selection (MLS) models, offspring communities are generated by random assembly of individuals in numbers reflecting sizes of parental communities releasing them (MLS1), or by differential community dispersal based on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f98928725a4900bafa852fdf3229988
https://doi.org/10.1101/2020.10.22.350272
https://doi.org/10.1101/2020.10.22.350272
Publikováno v:
Journal of medicinal chemistry. 63(10)
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH is a serious condition that can progress to cirrhosis, liver failure, and
Autor:
Catherine L. Jones, Surendra Machineni, Avantika Barve, Stephen Youngberg, Erin Brandt, Richard Colvin, Kristina Dabovic, Christopher T. Jones
Publikováno v:
Journal of Drug Assessment
Objective: Infection with hepatitis C virus is the leading indication for liver transplantation and most common cause of infectious disease-related mortality in the United States. BZF961 is a novel inhibitor of the hepatitis C virus NS3-4A protease.
Publikováno v:
Molecular Biology and Evolution. 35:1473-1488
When a substitution model is fitted to an alignment using maximum likelihood, its parameters are adjusted to account for as much site-pattern variation as possible. A parameter might therefore absorb a substantial quantity of the total variance in an