Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants.

Autor: Katherine E Zarn, Sierra A Jaramillo, Anthony R Zapata, Nathan E Stone, Ashley N Jones, Haley E Nunnally, Erik W Settles, Ken Ng, Paul S Keim, Steen Knudsen, Patricia M Nuijten, Aloys S L Tijsma, Christopher T French

Publikováno v: PLoS ONE, Vol 17, Iss 9, p e0272916 (2022)

We recently published a preliminary assessment of the activity of a poly (ADP-ribose) polymerase (PARP) inhibitor, stenoparib, also known as 2X-121, which inhibits viral replication by affecting pathways of the host. Here we show that stenoparib effe

Externí odkaz: https://doaj.org/article/c357ea60bd48412497cead77395a1e82

The PAAR5 Protein of a Polarly-Localized Type VI Secretion System (T6SS-5) is Required for the Formation of Multinucleated Cells (MNCs) and Virulence byBurkholderia pseudomallei

Autor: Christopher T. French, Philip Bulterys, Javier Ceja-Navarro, David Deshazer, Kenneth Ng

TheBurkholderia pseudomalleicomplex (Bpc) includesB. pseudomallei, B. malleiandB. thailandensis. These species share conserved virulence determinants that facilitate survival in mammalian cells and can spread from cell to cell by a unique mechanism i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c283d6d9445d79b7badff370c505acc
https://doi.org/10.1101/2023.02.09.527577

An in situ high-throughput screen identifies inhibitors of intracellular Burkholderia pseudomallei with therapeutic efficacy

Autor: Philip L. Bulterys, Isabelle J. Toesca, Michael H. Norris, Jeffrey P. Maloy, Sorel T. Fitz-Gibbon, Bryan France, Babak Toffig, Marco Morselli, Nawarat Somprasong, Matteo Pellegrini, Herbert P. Schweizer, Apichai Tuanyok, Robert Damoiseaux, Christopher T. French, Jeff F. Miller

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Burkholderia pseudomallei, the etiologic agent of melioidosis, is an environmental organism that inhabits tropical soils and kills an estimated 90,000 people each year. Caused by an intracellular and often drug-resistant pathogen, melioi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e259314e9b69809b3fc936d0afe0ea4
http://europepmc.org/articles/PMC6744847

Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerase (PARP), blocks replication of the SARS-CoV-2 human coronavirus in vitro

Autor: Christopher T French, Nathan E. Stone, David M. Wagner, Adam J. Vazquez, Erik W. Settles, Haley E Nunnally, Madison Martz, Paul Keim, Marlee O. Raniere, Sierra A. Jaramillo, Ashley N Jones, Jason W. Sahl, Steen Knudsen, Lora M. Versluis, Roxanne Nottingham, Katherine E. Zarn

By late 2020, the coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 has caused tens of millions of infections and over 1 million deaths worldwide. A protective vaccine and more effective therapeutics are urgently needed. We evaluated a ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5f5fcd2ddd26e8384855c8a634b2f5e
https://doi.org/10.1101/2020.11.12.380394

Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis

Autor: Christopher T. French, Rattanaphone Phetsouvanh, Manophab Luangraj, David A. B. Dance, Manivanh Vongsouvath, Paul N. Newton, Thyl Miliya, Paul Turner, Michelle A Bulterys, Sabine Kloprogge, Jeff F. Miller, Philip L. Bulterys, Koukeo Phommasone, Mayfong Mayxay

Publikováno v: The Lancet Planetary Health, 2(8), e334-e343. Elsevier BV
The Lancet Planetary Health, Vol 2, Iss 8, Pp e334-e343 (2018)
The Lancet. Planetary Health

Summary: Background: Burkholderia pseudomallei is the cause of melioidosis, a serious and difficult to treat infection that is endemic throughout the tropics. Melioidosis incidence is highly seasonal. We aimed to identify the climatic drivers of infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffc97cfa690c668951a259e01111abd
https://pure.amc.nl/en/publications/climatic-drivers-of-melioidosis-in-laos-and-cambodia-a-16year-case-series-analysis(8c247fd5-d773-48fc-b8cd-25cac807118a).html