Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher T, Salatto"'
Autor:
Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K. Smith, Emily A. Day, Chuong Nguyen, Kieran F. Geoghegan, John M. Kreeger, Alan Opsahl, Jessica Ward, Amit S. Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F. Osborne, Gregory R. Steinberg, Morris J. Birnbaum, Kimberly O. Cameron, Russell A. Miller
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 122-132 (2018)
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-A
Externí odkaz:
https://doaj.org/article/3a6b1a8ecd964eee8550aafb2b27ef05
Autor:
Liuqing Wei, Jun Xiao, Joseph S. Warmus, Jeffrey R. Chabot, Robert Dullea, Christopher T. Salatto, David W. Piotrowski, Benjamin A. Thuma, Donna N. Petersen, Chris Limberakis, Julien Genovino, Steven B. Coffey, Michael W. Bolt, Kim F. McClure, Kevin D. Hesp, Spiros Liras, Jamie H. D. Cate, Nathanael G. Lintner, Allyn T. Londregan, Gary Erik Aspnes, Benjamin Reidich
Publikováno v:
Journal of Medicinal Chemistry. 61:5704-5718
The optimization of a new class of small molecule PCSK9 mRNA translation inhibitors is described. The potency, physicochemical properties, and off-target pharmacology associated with the hit compound (1) were improved by changes to two regions of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46075104e513dd56e96e55dc41b689b9
https://doi.org/10.1021/acs.jmedchem.8b00650
https://doi.org/10.1021/acs.jmedchem.8b00650
Autor:
Jessica Ward, Jason Barricklow, Chuong Nguyen, Eliza Bollinger, Christopher T. Salatto, Bina Albuquerque, Mara Monetti, Norimitsu Shirai, Emily A. Day, Emily Cokorinos, Kieran F. Geoghegan, Gregory R. Steinberg, Rob Moccia, Matthew Peloquin, Ryan M. Esquejo, Morris J. Birnbaum, Russell A. Miller, Alan C. Opsahl, Brennan K. Smith, Jake Delmore, Kimberly O. Cameron, Timothy F. Osborne, Allan R. Reyes, John M. Kreeger, Lynne Butler, David A. Tess, Amit S. Kalgutkar, Yuji Shi
Publikováno v:
EBioMedicine, Vol 31, Iss, Pp 122-132 (2018)
EBioMedicine
EBioMedicine
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f1c5af9f8bcc8ab432732a5031a0fe
http://www.sciencedirect.com/science/article/pii/S2352396418301373
http://www.sciencedirect.com/science/article/pii/S2352396418301373
Autor:
Dennis O. Scott, Spiros Liras, Roger B. Ruggeri, Heather Eng, Adam S. Kamlet, Ryosuke Arakawa, David W. Piotrowski, Robert Dullea, Christopher T. Salatto, Karen Atkinson, Michael W. Bolt, Anne-Marie R. Dechert-Schmitt, Paul DaSilva-Jardine, Allyn T. Londregan, Brian Raymer, Kenneth Dahl, Daniel P. Canterbury, Donna N. Petersen, Paula M. Loria, Chris Limberakis, Emi Kimoto, Kim F. McClure, Kevin Beaumont, Liuqing Wei, Akihiro Takano, Kevin P. Maresca, Jun Xiao, Amanda King-Ahmad, Christer Halldin, Benjamin Reidich, Jeffrey R. Chabot
Publikováno v:
Angewandte Chemie International Edition. 56:16218-16222
Targeting of the human ribosome is an unprecedented therapeutic modality with a genome-wide selectivity challenge. A liver-targeted drug candidate is described that inhibits ribosomal synthesis of PCSK9, a lipid regulator considered undruggable by sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284063acd5910c34eb16ba576995a299
https://doi.org/10.1002/anie.201708744
https://doi.org/10.1002/anie.201708744
Autor:
Paul DaSilva-Jardine, Jessica Ward, Katherine Cialdea, Matthew F. Calabrese, Marina Amaro, Harmeet Gandhok, Francis Rajamohan, Alan C. Opsahl, Mara Monetti, Kimberly O. Cameron, Tim Rolph, Eliza Bollinger, Benjamin S. Maciejewski, Ravi G. Kurumbail, Christopher T. Salatto, Timothy M. Coskran, David A. Tess, Aditi Jatkar, Nathan E. Genung, Emily Cokorinos, Allan R. Reyes, Morris J. Birnbaum, Germaine Boucher, John M. Kreeger, Andre Shavnya, David J. Edmonds, Russell A. Miller, Amit S. Kalgutkar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:303-311
Diabetic nephropathy remains an area of high unmet medical need, with current therapies that slow down, but do not prevent, the progression of disease. A reduced phosphorylation state of adenosine monophosphate-activated protein kinase (AMPK) has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f66e0afa566f1f67e7eeedde3c3b2a37
https://doi.org/10.1124/jpet.116.237925
https://doi.org/10.1124/jpet.116.237925
Autor:
Jane M. Withka, Daniel W. Kung, Russell A. Miller, Matthew S. Dowling, Aaron C. Smith, Angela Wolford, Heather Eng, Janice A. Brown, Jun Xiao, Kris A. Borzilleri, Ravi G. Kurumbail, David J. Edmonds, Jessica Ward, Amit S. Kalgutkar, Colin R. Rose, Tim F. Ryder, Meihua Tu, Dilinie P. Fernando, Emily Cokorinos, David Hepworth, James A. Landro, Kimberly O. Cameron, Matthew F. Calabrese, Christopher T. Salatto, Francis Rajamohan, Andre Shavnya, Markus Boehm, Yuxia Mao, Allan R. Reyes, Richard K. Frisbie, Nicole Caspers, Edward L. Conn, Samit Kumar Bhattacharya
Publikováno v:
Journal of Medicinal Chemistry. 59:8068-8081
Adenosine monophosphate-activated protein kinase (AMPK) is a protein kinase involved in maintaining energy homeostasis within cells. On the basis of human genetic association data, AMPK activators were pursued for the treatment of diabetic nephropath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635e2459bb078e726c0e9a8f44099dcd
https://doi.org/10.1021/acs.jmedchem.6b00866
https://doi.org/10.1021/acs.jmedchem.6b00866
Autor:
Kimberly O. Cameron, Kevin J. Filipski, Jana Polivkova, Matthew S. Dowling, Andre Shavnya, Gary Erik Aspnes, David Christopher Ebner, Allan R. Reyes, Qifang Li, Michael Herr, Jun Xiao, Jessica Ward, Shawn Cabral, Heather Eng, Sophie Y. Lavergne, Ravi G. Kurumbail, Jane M. Withka, Samit Kumar Bhattacharya, Dilinie P. Fernando, Meihua Tu, Edward L. Conn, Bo Feng, Janice A. Brown, Daniel W. Kung, Francis Rajamohan, Esther C.Y. Lee, Russell A. Miller, Emily Cokorinos, Christopher T. Salatto, Nicole Caspers, Nathan E. Genung, Jane Panteleev, Benjamin A. Thuma, Matthew F. Calabrese, Sumathy Mathialagan, Aaron C. Smith, Kris A. Borzilleri, David J. Edmonds, Amit S. Kalgutkar
Publikováno v:
Journal of medicinal chemistry. 61(6)
Optimization of the pharmacokinetic (PK) properties of a series of activators of adenosine monophosphate-activated protein kinase (AMPK) is described. Derivatives of the previously described 5-aryl-indole-3-carboxylic acid clinical candidate (1) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ccac15ee02a34e6adc23a5d238341d
https://pubmed.ncbi.nlm.nih.gov/29466005
https://pubmed.ncbi.nlm.nih.gov/29466005
Autor:
Boris A. Chrunyk, Vincent Mascitti, Michael M. Baksh, Robert Dullea, Marc D. Roy, David Price, Cathy Préville, Carlos A. Sanhueza, Wen Lin, Elnaz Menhaji-Klotz, Meihua Tu, Amanda King-Ahmad, David F. Gebhard, Benjamin A. Thuma, Mark Ammirati, James E. Finley, Christopher T. Salatto, Spiros Liras, Sanjay Dutta, Shenping Liu, Benjamin Reidich, Kevin Beaumont, Ingrid A. Stock, Karen Atkinson, Rajesh Kumar, M. G. Finn
Publikováno v:
Journal of the American Chemical Society. 139(9)
A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency, and the molecular details of binding were revealed by the first X-ray crystal structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960308770c3c39141859f247dd5ef639
https://pubmed.ncbi.nlm.nih.gov/28230359
https://pubmed.ncbi.nlm.nih.gov/28230359
Autor:
Christopher T, Salatto, Russell A, Miller, Kimberly O, Cameron, Emily, Cokorinos, Allan, Reyes, Jessica, Ward, Matthew F, Calabrese, Ravi G, Kurumbail, Francis, Rajamohan, Amit S, Kalgutkar, David A, Tess, Andre, Shavnya, Nathan E, Genung, David J, Edmonds, Aditi, Jatkar, Benjamin S, Maciejewski, Marina, Amaro, Harmeet, Gandhok, Mara, Monetti, Katherine, Cialdea, Eliza, Bollinger, John M, Kreeger, Timothy M, Coskran, Alan C, Opsahl, Germaine G, Boucher, Morris J, Birnbaum, Paul, DaSilva-Jardine, Tim, Rolph
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(2)
Diabetic nephropathy remains an area of high unmet medical need, with current therapies that slow down, but do not prevent, the progression of disease. A reduced phosphorylation state of adenosine monophosphate-activated protein kinase (AMPK) has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dabb362de095f5aa2c5ef6849429242e
https://pubmed.ncbi.nlm.nih.gov/28289077
https://pubmed.ncbi.nlm.nih.gov/28289077
Autor:
Yan Weng, Christopher T. Salatto, Robert V. Stanton, Debra Moshinsky, Debra A. DiMattia, Mei Liu, John M. Kreeger, Robert Dullea, Jessie Qian, Marc D. Roy, Tracey Clark, Jeremy Little, Evan Walters, Simone Sciabola, Tracy Chen
Publikováno v:
Nucleic Acid Therapeutics. 22:344-359
A series of insertion patterns for chemically modified nucleotides [2'-O-methyl (2'-OMe), 2'-fluoro (2'-F), methoxyethyl (MOE), locked nucleic acid (LNA), and G-Clamp] within antisense gapmers is studied in vitro and in vivo in the context of the glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7c8f19b047c941c55b125e110c3fdf
https://doi.org/10.1089/nat.2012.0366
https://doi.org/10.1089/nat.2012.0366