Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Christopher Slape"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 4, Pp 315-321 (2007)
In the most common form of stem cell leukemia (SCL) gene rearrangement, an interstitial deletion of 82 kb brings SCL under the control of regulatory elements that normally govern expression of the ubiquitously expressed SCL interrupting locus (SIL) g
Externí odkaz:
https://doaj.org/article/28d86cceffd746c9a5142570530c99b1
Publikováno v:
Haematologica, Vol 93, Iss 9 (2008)
Expression of a NUP98-HOXD13 (NHD13) fusion gene, initially identified in a patient with myelodysplastic syndrome, leads to a highly penetrant myelodysplastic syndrome in mice that recapitulates all of the key features of the human disease. Expansion
Externí odkaz:
https://doaj.org/article/87875e17a6c140f8a977cb63f013fb0e
Supplementary Figures and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6649a8801e88917050969e78fb350424
https://doi.org/10.1158/0008-5472.22367795.v1
https://doi.org/10.1158/0008-5472.22367795.v1
Autor:
Peter D. Aplan, Christopher Slape, Stephen D. Nimer, Norman N. Iscove, Mary Barbara, Ramona Deveney, Ying-Wei Lin
OLIG2 (originally designated BHLHB1) encodes a transcription factor that contains the basic helix-loop-helix motif. Although expression of OLIG2 is normally restricted to neural tissues, overexpression of OLIG2 has been shown in patients with precurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c007920e5206d78836ad4e6eef6d09ca
https://doi.org/10.1158/0008-5472.c.6493604
https://doi.org/10.1158/0008-5472.c.6493604
Autor:
Peter D. Aplan, Christopher Slape, Stephen D. Nimer, Norman N. Iscove, Mary Barbara, Ramona Deveney, Ying-Wei Lin
Supplementary Figure 3 from OLIG2 (BHLHB1), a bHLH Transcription Factor, Contributes to Leukemogenesis in Concert with LMO1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187645239093dab64c8d184750e15fbb
https://doi.org/10.1158/0008-5472.22363211
https://doi.org/10.1158/0008-5472.22363211
Autor:
Peter D. Aplan, Christopher Slape, Stephen D. Nimer, Norman N. Iscove, Mary Barbara, Ramona Deveney, Ying-Wei Lin
Supplementary Figure 1 from OLIG2 (BHLHB1), a bHLH Transcription Factor, Contributes to Leukemogenesis in Concert with LMO1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207752c2b0fbf469a024da87e123c5b1
https://doi.org/10.1158/0008-5472.22363217
https://doi.org/10.1158/0008-5472.22363217
Autor:
Peter D. Aplan, Christopher Slape, Stephen D. Nimer, Norman N. Iscove, Mary Barbara, Ramona Deveney, Ying-Wei Lin
Supplementary Figure 2 from OLIG2 (BHLHB1), a bHLH Transcription Factor, Contributes to Leukemogenesis in Concert with LMO1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f78021a15aa2cf19991b6bbdd557ce
https://doi.org/10.1158/0008-5472.22363214.v1
https://doi.org/10.1158/0008-5472.22363214.v1
The t(2;11)(q31;p15) chromosomal translocation results in a fusion between the NUP98 and HOXD13 genes and has been observed in patients with myelodysplastic syndrome (MDS) or acute myelogenous leukemia. We previously showed that expression of the NUP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e474eccba1783d6ec9bdac368d50343
https://doi.org/10.1158/0008-5472.c.6495692
https://doi.org/10.1158/0008-5472.c.6495692
Autor:
Ngoc Vo, Christopher Slape, Wei Shi, Benjamin J. Shields, Jacob T. Jackson, Hansini Ranasinghe, David J. Curtis, Matthew P. McCormack, Adriana Pliego-Zamora
Publikováno v:
Leukemia. 33:1868-1880
T cell acute lymphoblastic leukaemia (T-ALL) cases include subfamilies that overexpress the TAL1/LMO, TLX1/3 and HOXA transcription factor oncogenes. While it has been shown that TAL1/LMO transcription factors induce self-renewal of thymocytes, wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b32023bc033e5e12b084323fdbd7b2
https://doi.org/10.1038/s41375-018-0361-0
https://doi.org/10.1038/s41375-018-0361-0
Autor:
Christopher Slape
Publikováno v:
Nature Structural & Molecular Biology. 28:123-124
NUP98 is one of the most promiscuous fusion partners involved in leukemogenic chromosomal translocations, but the myriad of partners has long obfuscated the mechanism by which these fusion proteins drive leukemia. A new mass spectrometry–based appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3898e45356eaa633d0bc20ee1b84ca5f
https://doi.org/10.1038/s41594-021-00558-w
https://doi.org/10.1038/s41594-021-00558-w