Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christopher Severson"'
Autor:
Lisa M Maier, Christopher E Lowe, Jason Cooper, Kate Downes, David E Anderson, Christopher Severson, Pamela M Clark, Brian Healy, Neil Walker, Cristin Aubin, Jorge R Oksenberg, Stephen L Hauser, Alistair Compston, Stephen Sawcer, International Multiple Sclerosis Genetics Consortium, Philip L De Jager, Linda S Wicker, John A Todd, David A Hafler
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000322 (2009)
Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by shared alleles. For decades, the Human Leukocyte Antigen (HLA) complex was the only known susceptib
Externí odkaz:
https://doaj.org/article/4baacb66870c472592ed19d87926184e
Autor:
Sarah Conway, Shrishti Saxena, Clare Baecher-Allan, Rajesh Krishnan, Maria Houtchens, Bonnie Glanz, Taylor J Saraceno, Mariann Polgar-Turcsanyi, Gauruv Bose, Rohit Bakshi, Shamik Bhattacharyya, Kristin Galetta, Tamara Kaplan, Christopher Severson, Tarun Singhal, Lynn Stazzone, Jonathan Zurawski, Anu Paul, Howard L Weiner, Brian C Healy, Tanuja Chitnis
Publikováno v:
Multiple Sclerosis Journal - Experimental, Translational and Clinical. 9:205521732311651
Background There is limited knowledge about T cell responses in patients with multiple sclerosis (MS) after 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine. Objectives Assess the SARS-CoV-2 spike antibody and T ce
Autor:
Kathryn B. Holroyd, Brian C. Healy, Sarah Conway, Maria Houtchens, Rohit Bakshi, Shamik Bhattacharyya, Gauruv Bose, Kristin Galetta, Tamara Kaplan, Christopher Severson, Tarun Singhal, Lynn Stazzone, Jonathan Zurawski, Mariann Polgar-Turcsanyi, Shrishti Saxena, Anu Paul, Bonnie I. Glanz, Howard L. Weiner, Tanuja Chitnis
Publikováno v:
Multiple Sclerosis and Related Disorders. 67:104079
Patients with multiple sclerosis (MS) on some disease modifying therapies (DMTs), particularly anti-CD20 and sphingosine-1-phosphate (S1P) modulators, are at increased risk of severe Coronavirus Disease 19 (COVID-19) and death. COVID-19 vaccinations
Autor:
Maria Claudia Manieri, Christopher Severson, Idanis Berriosmorales, Michael Elkort, Ellen Lathi, Tanuja Chitnis, Maria K. Houtchens, Tatenda Mahlanza, Eric C. Klawiter, Ann Cabot, Joshua Katz, James Stankiewicz, Andrew J. Solomon, Riley Bove, Carolina Ionete
Publikováno v:
Multiple sclerosis (Houndmills, Basingstoke, England). 27(1)
Background: The importance of supporting pregnancy-related decisions in multiple sclerosis (MS) patients has increasingly been recognized and hence the need for prospective data on pregnancy and pediatric outcomes in this patient population. Objectiv
Autor:
Jennifer Graves, Adrian Pace, Maria Pia Sormani, Devon S. Conway, Bianca Weinstock-Guttman, Frederick E. Munschauer, Corey C. Ford, Vernon Rowe, Jana Lizrova Preiningerova, Shiv Saidha, Radek Ampapa, Jens Kuhle, Harold L. Moses, Claire S Riley, Tobias Derfuss, Lilyana Amezcua, Joshua Barton, Kottil Rammohan, Pierre Duquette, Thomas Leist, Alexander Rae-Grant, Evanthia Bernitsas, Myla D. Goldman, R. Talab, Jerry S. Wolinsky, Nina De Klippel, Guillermo Izquierdo Ayuso, Bridget Bagert, Virginia Devonshire, Mariko Kita, Hayrettin Tumani, Bhatia Perminder, Scott D. Newsome, Paul S. Giacomini, Frédéric Sedel, Jan Lycke, M. S. Freedman, Stewart Webb, Sanjay Yathiraj, Agata Klosek, Stephen Krieger, Edward Fox, Malgorzata Zajda, Eva Meluzinova, Valerie J Block, Lluís Ramió-Torrentà, John R. Corboy, Aaron E. Miller, Xavier Montalban, Mark A. Agius, Michelle L Apperson, Patricia K. Coyle, Giancarlo Comi, Jose Enrique Martinez Rodriguez, Daniela Rau, Derrick Robertson, Elias Hamp Birte, Douglas L. Arnold, Fred D. Lublin, Galina Vorobeychik, Benjamin Greenberg, Mathias Buttmann, Daniel Bandari, Ludivine Witkowski, Sharon G. Lynch, Victoria Fernandez Sanchez, Jonathan Calkwood, Maria Satori, Tania Kuempfel, Rana K. Zabad, J. Marc Girard, Bruce A.C. Cree, Ahmed T. Toosy, Don J. Mahad, Bruce A. Cohen, Jozef Koscielniak, Jonathan Carter, Daniel Selchen, Paul Friedemann, Sharon Stoll, Fryze Waldemar, Gerd Reifschneider, Mark S. Freedman, Gary Cutter, Franz Fazekas, Robert T. Naismith, Marta Vachova, Richard MacDonell, Mary Ann Picone, Gavin Giovannoni, Randall Trudell, Barbara Willekens, Orhan Aktas, Mark Marriott, Roger McKelvey, Bruce C.A. Cree, Christopher Severson, Rafael Arroyo Gonzalez, Kyle Smoot, Murat Terzi, Joanna Cooper, Lou Brundin, Hans-Peter Hartung, Piotr Sokolowski, Joe Guadagno, Stephen C. Reingold, Klaus Schmierer, Guy Laureys, Robert P. Lisak, Lawrence Samkoff, Carlo Pozzilli, Celia Oreja Guevara, Mitchel Freedman, Anthony T. Reder
Publikováno v:
The lancet neurology
Background: There is an unmet need to develop therapeutic interventions directed at the neurodegeneration that underlies progression in multiple sclerosis. High-dose, pharmaceutical-grade biotin (MD1003) might enhance neuronal and oligodendrocyte ene
Autor:
Michelle L Apperson, Silvia Delgado, P. K. Coyle, S. Narayanan, Michelle McGovern, Andrew D. Goodman, Eric C. Klawiter, Christopher Severson, Robert A. Bermel, J. P. Debbins, Bianca Weinstock-Guttman, Brenda Thornell, Enrique Alvarez, Jon W. Yankey, Michael K. Racke, Janel Barnes, P. Jagodnik, Robin Conwit, Stephen Krieger, Valerie Suski, Jeffrey D. Long, Vijayshree Yadav, Khurram Bashir, Merit Cudkowicz, B. Thoomukuntla, Trevis Gleason, Kenneth Earl Sakaie, Jai Perumal, Akshata Ashokkumar, Robert J. Fox, Aram Zabeti, Daniel Ontaneda, Kunio Nakamura, Dixie Ecklund, Harold L. Moses, Myla D. Goldman, Elizabeth A. Klingner, Maxine Koepp, Mark J. Lowe, Shlomo Shinnar, X. Zhou, Robert T. Naismith, Barbara Giesser, Christopher S. Coffey, Sharon G. Lynch, Pavle Repovic, K. Matsuda, Burk Jubelt, Neil Lava, X. Huang, Sneha Natarajan, L. D. Dewitt, A. Flores, Claire S Riley, Bruce A. Cohen
Publikováno v:
The New England journal of medicine, vol 379, iss 9
BackgroundThere are limited treatments for progressive multiple sclerosis. Ibudilast inhibits several cyclic nucleotide phosphodiesterases, macrophage migration inhibitory factor, and toll-like receptor 4 and can cross the blood-brain barrier, with p
Autor:
Dorlan J. Kimbrough, Lynn Stazzone, Brian C. Healy, Tanuja Chitnis, Shahamat Tauhid, Maria K. Houtchens, Renxin Chu, Howard L. Weiner, Gloria Kim, Francisco J. Quintana, Fawad Yousuf, Rohit Bakshi, Christopher Severson, James Stankiewicz
Publikováno v:
International Journal of Neuroscience. 127:971-980
The subcortical deep gray matter (DGM) develops selective, progressive, and clinically relevant atrophy in progressive forms of multiple sclerosis (PMS). This patient population is the target of active neurotherapeutic development, requiring the avai
Autor:
Mohit Neema, Jennifer Miller, James Stankiewicz, Antonia Ceccarelli, Christopher Severson, Lynn Stazzone, Rohit Bakshi, Gloria Kim, Charles R.G. Guttmann, Shahamat Tauhid, Riley Bove, Maria K. Houtchens, Tanuja Chitnis, Bonnie I. Glanz, Julia L. Berkowitz, Brian C. Healy, Howard L. Weiner
Publikováno v:
Neuroreport
The objective of this study was to test a new version of the Magnetic Resonance Disease Severity Scale (MRDSS2), incorporating cerebral gray matter (GM) and spinal cord involvement from 3 T MRI, in modeling the relationship between MRI and physical d
Autor:
Robert J. Fox, Michelle McGovern, Maxine Koepp, Thomai Skaramagas, Michael K. Racke, Vijayshree Yadav, Merit Cudkowicz, Silvia Delgado, Jeffrey D. Long, Augusto Miravalle, Jai Perumal, Myla D. Goldman, Mark A. Agius, Akshata Ashokkumar, Eric C. Klawiter, Robert A. Bermel, Angela Flores, Dixie Ecklund, Patricia K. Coyle, Andrew D. Goodman, Daniel Ontaneda, Kazuko Matsuda, Srividya Ramachandran, Trevis Gleason, Bianca Weinstock-Gutman, Robin Conwit, Valerie Suski, Claire S Riley, Aram Zabeti, Harold L. Moses, Christopher Severson, Dana Dewitt, Brenda Thornell, Shlomo Shinnar, Khurram Bashir, Neil Lava, Jon W. Yankey, Robert T. Naismith, Pavle Repovic, Sneha Natarajan, Bruce A. Cohen, Sharon G. Lynch, Barbara Giesser, Christopher S. Coffey, Burk Jubelt
Publikováno v:
Contemporary clinical trials. 50
Background Primary and secondary progressive multiple sclerosis (MS), collectively called progressive multiple sclerosis (PMS), is characterized by gradual progression of disability. The current anti-inflammatory treatments for MS have little or no e
Autor:
David A. Hafler, Philip L. De Jager, Christopher Severson, David M. Kofler, Narine Mousissian
Publikováno v:
The Journal of Immunology. 187:3286-3291
Genome-wide association studies have revealed a large number of genetic associations with autoimmune diseases. Despite this progress, the mechanisms underlying the contribution of allelic variants to the onset of immune-related diseases remain mostly