Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher S. Waters"'
A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113260- (2023)
Summary: Mechanisms that prevent accidental activation of the PINK1/Parkin mitophagy circuit on healthy mitochondria are poorly understood. On the surface of damaged mitochondria, PINK1 accumulates and acts as the input signal to a positive feedback
Externí odkaz:
https://doaj.org/article/1d17bce4d0a144888d732b6de877c34a
Autor:
Capria Rinaldi, Christopher S. Waters, Zizheng Li, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112447- (2023)
Summary: Parkinson’s disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead t
Externí odkaz:
https://doaj.org/article/96865a93efde46f3a41eee3b34861ca1
Autor:
Capria Rinaldi, Christopher S. Waters, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
Parkinson’s disease-causing LRRK2 mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead to higher levels of cellular Rab phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd4c07a6f724caa62b514c105245a99
https://doi.org/10.1101/2022.10.25.513743
https://doi.org/10.1101/2022.10.25.513743
Mechanisms that prevent accidental degradation of healthy mitochondria by the PINK1/Parkin mitophagy pathway are poorly understood. On the surface of damaged mitochondria, PINK1 accumulates and acts as the input signal to a positive feedback loop of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b70c4fd38f48cee910b891c2c0740445
https://doi.org/10.1101/2022.10.07.510659
https://doi.org/10.1101/2022.10.07.510659
Autor:
Benjamin J. Rauch, Christopher S. Waters, Melanie R. Silvis, Joseph Bondy-Denomy, Judd F. Hultquist, Nevan J. Krogan, Michael J. McGregor
Publikováno v:
Cell, vol 168, iss 1-2
Summary Bacterial CRISPR-Cas systems utilize sequence-specific RNA-guided nucleases to defend against bacteriophage infection. As a countermeasure, numerous phages are known that produce proteins to block the function of class 1 CRISPR-Cas systems. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f69578dd6ab675de6015a7f87a2a47
https://europepmc.org/articles/PMC5235966/
https://europepmc.org/articles/PMC5235966/
Autor:
Benjamin L. Ebert, Rahul S. Vedula, R. Coleman Lindsley, Gregory A. Abel, Shabbir M. Vahanvaty, Marie McConkey, Anne Charles, Marlise R. Luskin, Priti Kumari, Richard Stone, Christopher S. Waters, Kevin Copson, Iman Fares
Publikováno v:
Blood. 132:888-888
Somatic mutations can have highly stereotyped positions in the myeloid clonal hierarchy and distinct patterns of co-occurring mutations. Gene mutations that cause aberrant activation of RAS/MAPK signaling are typically late events in myeloid disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510badb056188c45df98977a2e25bb32
https://doi.org/10.1182/blood-2018-99-120096
https://doi.org/10.1182/blood-2018-99-120096
Autor:
Mónica S. Ventura Ferreira, Michelle C. Chen, Edwin Chen, Monica Schenone, R. Coleman Lindsley, Christopher S Waters, Fabian Beier, Cailin E. Joyce, Ulrich Germing, Rafael Kramann, Uwe Platzbecker, Tim H. Brümmendorf, Guntram Büsche, Steven A. Carr, Carl D. Novina, Christina R. Hartigan, Ruth Knüchel, Rebekka K. Schneider, Lisa P. Chu, Benjamin L. Ebert
Publikováno v:
Nature medicine. 22(3)
Impaired erythropoiesis in the deletion 5q (del(5q)) subtype of myelodysplastic syndrome (MDS) has been linked to heterozygous deletion of RPS14, which encodes the ribosomal protein small subunit 14. We generated mice with conditional inactivation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a924d46538c389d00ed97d90a09be2
https://pubmed.ncbi.nlm.nih.gov/26878232
https://pubmed.ncbi.nlm.nih.gov/26878232
Autor:
Schneider K. Rebekka, Monica Schenone, Benjamin L. Ebert, Ulrich Germing, Fabian Beier, Uwe Platzbecker, Marie McConkey, Monica Ferreira Ventura, Tim H. Bruemmendorf, R. Coleman Lindsley, Christopher S Waters, Guntram Büsche
Publikováno v:
Blood. 126:356-356
Heterozygous deletion of RPS14 occurs in del(5q) MDS and has been linked to impaired erythropoiesis, characteristic of this disease subtype. We previously generated a mouse model with conditional inactivation of Rps14 and demonstrated a p53-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::109c1cd40de45a9935462bdf90d308fe
https://doi.org/10.1182/blood.v126.23.356.356
https://doi.org/10.1182/blood.v126.23.356.356