Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Christopher S. Stipp"'
Autor:
Melissa A. Marchal, Devon L. Moose, Afshin Varzavand, Nicole E. Jordan, Destiney Taylor, Munir R. Tanas, James A. Brown, Michael D. Henry, Christopher S. Stipp
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionAbl family kinases function as proto-oncogenes in various leukemias, and pro-tumor functions have been discovered for Abl kinases in many solid tumors as well. However, a growing body of evidence indicates that Abl kinases can function to
Externí odkaz:
https://doaj.org/article/3f74f3b22e7d4202910ff27fb642931d
Autor:
Eliot Y. Zhu, Jesse D. Riordan, Marion Vanneste, Michael D. Henry, Christopher S. Stipp, Adam J. Dupuy
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract Rare gain-of-function mutations in RAC1 drive drug resistance to targeted BRAF inhibition in cutaneous melanoma. Here, we show that wildtype RAC1 is a critical driver of growth and drug resistance, but only in a subset of melanomas with elev
Externí odkaz:
https://doaj.org/article/e5fe1fcbf15a42ff9db070d5dc09d9f0
Autor:
Qierra R. Brockman, Amanda Scherer, Gavin R. McGivney, Wade R. Gutierrez, Andrew P. Voigt, Alexandra L. Isaacson, Emily A. Laverty, Grace Roughton, Vickie Knepper-Adrian, Benjamin Darbro, Munir R. Tanas, Christopher S. Stipp, Rebecca D. Dodd
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a c
Externí odkaz:
https://doaj.org/article/72aae0cfd35e4271a50d462f47391a87
Autor:
Marion Vanneste, Charlotte R. Feddersen, Afshin Varzavand, Elliot Y. Zhu, Tyler Foley, Lei Zhao, Kathleen H. Holt, Mohammed Milhem, Robert Piper, Christopher S. Stipp, Adam J. Dupuy, Michael D. Henry
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Patients with malignant melanoma have a 5-year survival rate of only 15–20% once the tumor has metastasized to distant tissues. While MAP kinase pathway inhibitors (MAPKi) are initially effective for the majority of patients with melanoma harboring
Externí odkaz:
https://doaj.org/article/95a586feb3bf41228e4c027d0dc87c64
Autor:
Devon L. Moose, Benjamin L. Krog, Tae-Hyung Kim, Lei Zhao, Sophia Williams-Perez, Gretchen Burke, Lillian Rhodes, Marion Vanneste, Patrick Breheny, Mohammed Milhem, Christopher S. Stipp, Amy C. Rowat, Michael D. Henry
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3864-3874.e6 (2020)
Summary: During metastasis, cancer cells are exposed to potentially destructive hemodynamic forces including fluid shear stress (FSS) while en route to distant sites. However, prior work indicates that cancer cells are more resistant to brief pulses
Externí odkaz:
https://doaj.org/article/90d7b137bfca43899cdd2b65c1b3c7df
Autor:
Xinyu Deng, Qinglin Li, John Hoff, Marian Novak, Helen Yang, Hongyan Jin, Sonia F. Erfani, Chandan Sharma, Pengcheng Zhou, Isaac Rabinovitz, Arnoud Sonnenberg, Yajun Yi, Peter Zhou, Christopher S. Stipp, David M. Kaetzel, Martin E. Hemler, Xiuwei H. Yang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 8, Pp 678-689 (2012)
ErbB2+ human breast cancer is a major clinical problem. Prior results have suggested that tetraspanin CD151 might contribute to ErbB2-driven breast cancer growth, survival, and metastasis. In other cancer types, CD151 sometimes supports tumor growth
Externí odkaz:
https://doaj.org/article/a257c98a30bc4c299e0d1c3613c71ad5
Autor:
Christopher S. Stipp, Michael D. Henry, Frederick E. Domann, Melissa Teoh-Fitzgerald, Elisabeth Gustafson-Wagner, Yihan Sun, Mary E. Herndon, Katherine N. Gibson-Corley, Bo Zhou
PDF file, 707K, S1. Comparison of alpha3beta1 and alpha6beta4 integrin expression in 4T1 cell lines. S2. BLI of spontaneous and experimental metastasis (color) S3. Certain large primary mammary fat pad tumors exhibited substantial centralized zones o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb8636473b7cd475c3699742cf87730
https://doi.org/10.1158/1541-7786.22509849.v1
https://doi.org/10.1158/1541-7786.22509849.v1
Autor:
Christopher S. Stipp, Michael D. Henry, Frederick E. Domann, Melissa Teoh-Fitzgerald, Elisabeth Gustafson-Wagner, Yihan Sun, Mary E. Herndon, Katherine N. Gibson-Corley, Bo Zhou
Significant evidence implicates α3β1 integrin in promoting breast cancer tumorigenesis and metastasis-associated cell behaviors in vitro and in vivo. However, the extent to which α3β1 is actually required for breast cancer metastasis remains to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41440bd6e18973d87c18ea4ac51b1aa
https://doi.org/10.1158/1541-7786.c.6539412
https://doi.org/10.1158/1541-7786.c.6539412
Autor:
Christopher S. Stipp, Michael D. Henry, Frederick E. Domann, Melissa Teoh-Fitzgerald, Elisabeth Gustafson-Wagner, Yihan Sun, Mary E. Herndon, Katherine N. Gibson-Corley, Bo Zhou
PDF file, 88K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc03033af24da35268a1d626cfc2f414
https://doi.org/10.1158/1541-7786.22509852
https://doi.org/10.1158/1541-7786.22509852
Autor:
Christopher S. Stipp, Michael D. Henry, Frederick E. Domann, Melissa Teoh-Fitzgerald, Elisabeth Gustafson-Wagner, Yihan Sun, Mary E. Herndon, Katherine N. Gibson-Corley, Bo Zhou
PDF file, 38K, Flow cytometry of integrin expression in 4T1 carcinoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc0602b3912b09612824d8ea9b3e39f
https://doi.org/10.1158/1541-7786.22509846
https://doi.org/10.1158/1541-7786.22509846