Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher S. Phillips"'
Autor:
Desmond I. Bannon, Wenjun Bao, James F. Dillman, Russ Wolfinger, Christopher S. Phillips, Edward J. Perkins
Publikováno v:
International Journal of Toxicology. 42:278-286
The nitramine explosive, hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is associated with acute and chronic toxicity in mammals and targets both the central nervous system and liver. After a single oral dose of RDX in male rats, the systemic distribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd3d4978974342919ed4662b72103de
https://doi.org/10.1177/10915818231157713
https://doi.org/10.1177/10915818231157713
Autor:
Chance M. Carbaugh, David A. Jackson, Valerie T. Divito, Kyle P. Glover, Mark W. Widder, William H. van der Schalie, Christopher S. Phillips
Publikováno v:
Journal of Applied Toxicology
Zebrafish are an attractive model for chemical screening due to their adaptability to high‐throughput platforms and ability to display complex phenotypes in response to chemical exposure. The photomotor response (PMR) is an established and reproduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fb5bf5d86477a8f7c929aca586da5c
http://europepmc.org/articles/PMC7496110
http://europepmc.org/articles/PMC7496110
Autor:
James F. Dillman, Christopher S. Phillips, Michael A. Hable, Edward J. Perkins, Desmond I. Bannon
Publikováno v:
Chemical Research in Toxicology. 22:620-625
RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) is a synthetic, high-impact, relatively stable explosive that has been in use since WWII. Exposure to RDX can occur in occupational settings (e.g., during manufacture) or through the inadvertent ingestion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac60db8221ad61f8b38b90e648f7247
https://doi.org/10.1021/tx800444k
https://doi.org/10.1021/tx800444k
Autor:
Alison I. Hege, Linda D. Orzolek, Christopher S. Phillips, James F. Dillman, Alfred M. Sciuto, Theodore S. Moran
Publikováno v:
Chemical Research in Toxicology. 18:1654-1660
Carbonyl chloride (phosgene) is a toxic industrial compound widely used in industry for the production of synthetic products, such as polyfoam rubber, plastics, and dyes. Exposure to phosgene results in a latent (1-24 h), potentially life-threatening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c485cb5318c16e1ada663ab5463c87a0
https://doi.org/10.1021/tx050126f
https://doi.org/10.1021/tx050126f
Publikováno v:
Toxicological Sciences. 87:306-314
Gene expression profiling is an important tool in the development of medical countermeasures against chemical warfare agents (CWAs). Non-human primates (NHPs), specifically the rhesus macaque (Macaca mulatta), the cynomologus macaque (Macaca fascicul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b0e4f9d3b7773dc335c689d73cf000
https://doi.org/10.1093/toxsci/kfi243
https://doi.org/10.1093/toxsci/kfi243
Autor:
Robert K. Kan, Christopher S. Phillips, Tracey A. Hamilton, Christina P. Tompkins, James F. Dillman, Denise M. Kniffin
Publikováno v:
Chemical research in toxicology. 22(4)
Soman (O-pinacolyl methylphosphonofluoridate) is a potent neurotoxicant. Acute exposure to soman causes acetylcholinesterase inhibition, resulting in excessive levels of acetylcholine. Excessive acetylcholine levels cause convulsions, seizures, and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eef8ce1f4a4296e350ea2decbc4e80e
https://pubmed.ncbi.nlm.nih.gov/19281266
https://pubmed.ncbi.nlm.nih.gov/19281266
Autor:
Robyn C. Kiser, Linda D. Orzolek, Christopher S. Phillips, Carol L. K. Sabourin, Alison I. Hege, John J. Schlager, Carol Bossone, Albert J. Sylvester, James F. Dillman, Young W. Choi, Claudia Henemyre-Harris
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 317(1)
Bis-(2-chloroethyl) sulfide (sulfur mustard; SM) is a potent alkylating agent. Three treatment compounds have been shown to limit SM damage in the mouse ear vesicant model: dimercaprol, octyl homovanillamide, and indomethacin. Microarrays were used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38d0b5316ca69cb6d5ffe8938142e89
https://pubmed.ncbi.nlm.nih.gov/16377760
https://pubmed.ncbi.nlm.nih.gov/16377760
Autor:
Matthew D. Croxton, Alfred M. Sciuto, Linda M. Dorsch, Theodore S. Moran, Alison I. Hege, Christopher S. Phillips, James F. Dillman, Albert J. Sylvester
Publikováno v:
Chemical research in toxicology. 18(1)
Bis-(2-chloroethyl) sulfide (sulfur mustard, SM) is a carcinogenic alkylating agent that has been utilized as a chemical warfare agent. To understand the mechanism of SM-induced lung injury, we analyzed global changes in gene expression in a rat lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0aa4380b74d976640306c5f2cf2422
https://pubmed.ncbi.nlm.nih.gov/15651846
https://pubmed.ncbi.nlm.nih.gov/15651846
Publikováno v:
Toxicological Sciences. 88:656-656
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39e2094a205ede818142302d6610f6d4
https://doi.org/10.1093/toxsci/kfi337
https://doi.org/10.1093/toxsci/kfi337
Autor:
James F. Dillman, Christopher S. Phillips, Denise M. Kniffin, Christina P. Tompkins, Tracey A. Hamilton, Robert K. Kan
Publikováno v:
Chemical Research in Toxicology; Apr2009, Vol. 22 Issue 4, p633-638, 6p