Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christopher S. Neumann"'
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Detailed methods for ADC analytics and chemical sysnthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916122efb9c585694b4a5165b3263a57
https://doi.org/10.1158/1535-7163.22505815
https://doi.org/10.1158/1535-7163.22505815
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Antibody–drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active payloads with unique mechanisms of action is a key aim of research efforts in the field. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::573a206071ce06934ff2470390402a2e
https://doi.org/10.1158/1535-7163.c.6538195.v1
https://doi.org/10.1158/1535-7163.c.6538195.v1
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Supplemental tables and figures referenced in main text: Table S1 - Crystallography data collection and refinement statistics; Table S2 - ADC characterization data; Figure S1 - ADC plasma stability data; Figure S2 - Time course for ADC activity in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db82a176dff235f814043a7bfa28d04
https://doi.org/10.1158/1535-7163.22505812
https://doi.org/10.1158/1535-7163.22505812
Autor:
John R. Heemstra, Wei Jiang, Frank C. Schroeder, Ry R. Forseth, Karl J. Hale, Soraya Manaviazar, Christopher S. Neumann, Christopher T. Walsh
Publikováno v:
Biochemistry
Kutznerides 2 and 8 of the cyclic hexadepsipeptide family of antifungal natural products from the soil actinomycete Kutzneria sp. 744 contain two sets of chlorinated residues, a 6,7-dichlorohexahydropyrroloindole moiety derived from dichlorotryptopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bb5323d4809606a7dbaa27c75c51a0
https://doi.org/10.1021/bi200656k
https://doi.org/10.1021/bi200656k
Autor:
Linde A. Miles, Megan L. Matthews, J. Martin Bollinger, Christopher S. Neumann, Tyler L. Grove, Squire J. Booker, Carsten Krebs, Christopher T. Walsh
Publikováno v:
Proceedings of the National Academy of Sciences. 106:17723-17728
The α-ketoglutarate-dependent hydroxylases and halogenases employ similar reaction mechanisms involving hydrogen-abstracting Fe(IV)-oxo (ferryl) intermediates. In the halogenases, the carboxylate residue from the His 2 (Asp/Glu) 1 “facial triad”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db02e12eb4506da549453b14d51be9f
https://doi.org/10.1073/pnas.0909649106
https://doi.org/10.1073/pnas.0909649106
Publikováno v:
Chemistry & Biology. 15(2):99-109
Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f6aab7781b332d0f9e6d33166ffbd6
Publikováno v:
Angewandte Chemie. 117:2289-2292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804394b305c659558cbd1e94daed399d
https://doi.org/10.1002/ange.200462798
https://doi.org/10.1002/ange.200462798
Autor:
Roberto Kolter, Christopher T. Walsh, Christopher S. Neumann, Erin A. Gontang, Wei Jiang, John R. Heemstra
Publikováno v:
Chembiochem : a European journal of chemical biology. 13(7)
Which came first? We have investigated the biosynthesis of the piperazic acid (Piz) building blocks in the kutzneride family of metabolites. The flavin-dependent oxygenase KtzI was shown to convert ornithine to N(5)-OH-Orn. LC-MS/MS showed (13)C(5)-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3207ac152c5cd968996045a58c8ab3f
https://pubmed.ncbi.nlm.nih.gov/22522643
https://pubmed.ncbi.nlm.nih.gov/22522643
Autor:
Robert R. Kay, Israel S. Fernández, Christopher S. Neumann, Francisco Velazquez, Sew Yu Peak-Chew
Publikováno v:
Chemistry & Biology
Summary Chlorinated compounds are important environmental pollutants whose biodegradation may be limited by inefficient dechlorinating enzymes. Dictyostelium amoebae produce a chlorinated alkyl phenone called DIF which induces stalk cell differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c2f3e43fcfec1cf5e81c77ea0cb752
https://pubmed.ncbi.nlm.nih.gov/22035794
https://pubmed.ncbi.nlm.nih.gov/22035794
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(13)
Differentiation-inducing factor 1 (DIF-1) is a polyketide-derived morphogen which drives stalk cell formation in the developmental cycle of Dictyostelium discoideum . Previous experiments demonstrated that the biosynthetic pathway proceeds via dichlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1aec3b90168d34f11ec5ac01d28850b
https://pubmed.ncbi.nlm.nih.gov/20231486
https://pubmed.ncbi.nlm.nih.gov/20231486