Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Christopher S. Navara"'
Autor:
Megan A. Mahlke, Keren Cheng, Bo Li, Shital Chaudhari, Christopher S. Navara, John R. McCarrey
Publikováno v:
Stem Cell Research, Vol 57, Iss , Pp 102598- (2021)
Translation of stem cell therapies to the clinic will be most successful following optimization of efficacy and safety in appropriate preclinical model systems. Among available models, nonhuman primates (NHPs) provide the most accurate recapitulation
Externí odkaz:
https://doaj.org/article/a969653549e44c7ba28724dcb7160c0a
Autor:
Douglas A. Grow, DeNard V. Simmons, Jorge A. Gomez, Matthew J. Wanat, John R. McCarrey, Carlos A. Paladini, Christopher S. Navara
Publikováno v:
Stem Cells Translational Medicine, Vol 5, Iss 9, Pp 1133-1144 (2016)
The progressive death of dopamine producing neurons in the substantia nigra pars compacta is the principal cause of symptoms of Parkinson's disease (PD). Stem cells have potential therapeutic use in replacing these cells and restoring function. To fa
Externí odkaz:
https://doaj.org/article/5397b91cb5cf46fb9fe3b5ba9cea569d
Publikováno v:
Stem Cell Research, Vol 17, Iss 2, Pp 352-366 (2016)
The derivation of dopaminergic neurons from induced pluripotent stem cells brings new hope for a patient-specific, stem cell-based replacement therapy to treat Parkinson's disease (PD) and related neurodegenerative diseases; and this novel cell-based
Externí odkaz:
https://doaj.org/article/a2760866f550426bb46f41ef6b9282a2
Publikováno v:
Stem Cell Research, Vol 12, Iss 2, Pp 539-549 (2014)
The BIRC5 gene encodes the oncofetal protein SURVIVIN, as well as four additional splice variants (ΔEx3, 2B, 3B and 2α). SURVIVIN, an inhibitor of apoptosis, is also a chromosomal passenger protein (CPP). Previous results have demonstrated that SUR
Externí odkaz:
https://doaj.org/article/7059782d4dbb4cffb7875b7c6dbecffe
Autor:
Yasunari Seita, Keren Cheng, John R McCarrey, Nomesh Yadu, Ian H Cheeseman, Alec Bagwell, Corinna N Ross, Isamar Santana Toro, Li-hua Yen, Sean Vargas, Christopher S Navara, Brian P Hermann, Kotaro Sasaki
Publikováno v:
eLife, Vol 12 (2023)
Reconstitution of germ cell fate from pluripotent stem cells provides an opportunity to understand the molecular underpinnings of germ cell development. Here, we established robust methods for induced pluripotent stem cell (iPSC) culture in the commo
Externí odkaz:
https://doaj.org/article/fcaf5e16ae334e4491f3cc60f5808524
Autor:
Keren Cheng, Yasunari Seita, John R McCarrey, Nomesh Yadu, Ian H Cheeseman, Alec Bagwell, Corinna N Ross, Isamar Santana Toro, Li-hua Yen, Sean Vargas, Christopher S Navara, Brian P Hermann, Kotaro Sasaki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::634a91c9ea182c6aae93f732f1fca109
https://doi.org/10.7554/elife.82263.sa2
https://doi.org/10.7554/elife.82263.sa2
Autor:
Sy Griffey, Christopher S. Navara, Alejandro L. Morales Betancourt, Joo L. Ong, Sergio A. Montelongo, Teja Guda, Solaleh Miar, Rogelio Zamilpa, Joseph J. Pearson, Bharath Ram, Mark R. Appleford
Publikováno v:
J Biomed Mater Res B Appl Biomater
Extracellular matrix (ECM) products have the potential to improve cellular attachment and promote tissue-specific development by mimicking the native cellular niche. In this study, the therapeutic efficacy of an ECM substratum produced by bone marrow
Autor:
Carrie Hartnett, Gerald Schatten, Calvin Simerly, Carlos A. Castro, Laura Hewitson, Ethan Jacoby, Diana Takahashi, Christopher S. Navara
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
With nearly ten million babies conceived globally, using assisted reproductive technologies, fundamental questions remain; e.g., How do the sperm and egg DNA unite? Does ICSI have consequences that IVF does not? Here, pronuclear and mitotic events in
Publikováno v:
Stem Cell Research, Vol 17, Iss 2, Pp 352-366 (2016)
The derivation of dopaminergic neurons from induced pluripotent stem cells brings new hope for a patient-specific, stem cell-based replacement therapy to treat Parkinson's disease (PD) and related neurodegenerative diseases; and this novel cell-based
Autor:
John R. McCarrey, Christopher S. Navara, Carlos A. Paladini, Matthew J. Wanat, DeNard V. Simmons, Jorge A. Gomez, Douglas A. Grow
Publikováno v:
Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 5, Iss 9, Pp 1133-1144 (2016)
Stem Cells Translational Medicine, Vol 5, Iss 9, Pp 1133-1144 (2016)
This study differentiated baboon fibroblast-derived induced pluripotent stem cells into dopaminergic neurons with the application of specific morphogens and growth factors. The results show the utility of the baboon model for testing and optimizing t