Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christopher S. Malarkey"'
Autor:
Christopher S Malarkey, Claire E Gustafson, Jessica F Saifee, Raul M Torres, Mair E A Churchill, Edward N Janoff
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157157 (2016)
Mitochondrial transcription factor A (TFAM) had previously been shown to act as a damage associated molecular pattern with the ability to enhance CpG-A phosphorothioate oligodeoxynucleotide (ODN)-mediated stimulation of IFNα production from human pl
Externí odkaz:
https://doaj.org/article/a988412491364942ba84cc96a8b56d56
Autor:
Liam Portt, Melody A. Cobleigh, Timothy Yung, Matthew S. Najor, Abde M. Abukhdeir, Sanja Turturro, Christopher S. Malarkey
Publikováno v:
Breast Cancer Research and Treatment. 177:325-333
The PI3K pathway, which includes the PI3K catalytic subunits p110α (PIK3CA) and the PI3K regulatory subunit p85α (PIK3R1), is the most frequently altered pathway in cancer. We encountered a breast cancer patient whose tumor contained a somatic alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2815fcd20ba30ab9171fe0b0380472
https://doi.org/10.1007/s10549-019-05320-x
https://doi.org/10.1007/s10549-019-05320-x
Autor:
Sanja B, Turturro, Matthew S, Najor, Timothy, Yung, Liam, Portt, Christopher S, Malarkey, Abde M, Abukhdeir, Melody A, Cobleigh
Publikováno v:
Breast cancer research and treatment. 177(2)
The PI3K pathway, which includes the PI3K catalytic subunits p110α (PIK3CA) and the PI3K regulatory subunit p85α (PIK3R1), is the most frequently altered pathway in cancer. We encountered a breast cancer patient whose tumor contained a somatic alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93b97457d6a0cccf860c6202250dbc8a
https://pubmed.ncbi.nlm.nih.gov/31209687
https://pubmed.ncbi.nlm.nih.gov/31209687
Autor:
Shweta Shetty, Ernest D. Pianim, Patrick H. Hewitt, Christopher S. Malarkey, Nicholas A. DiCesare, Casey Gray, Jan V. Bernal, Trung T. Leong, Kuriko Sakai
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862:183106
Gastric cancer is associated with high mortality and is preceded by an infection with Helicobacter pylori (H. pylori). H. pylori stimulates inflammation which involves the activation of Toll-like receptor 4 by lipopolysaccharide molecules from the H.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c54f29d1509354e0a7ffafa2efff3af
https://doi.org/10.1016/j.bbamem.2019.183106
https://doi.org/10.1016/j.bbamem.2019.183106
Autor:
Núria Saperas, R. Sánchez-Giraldo, Mair E. A. Churchill, F.J. Acosta-Reyes, J.L. Campos, Christopher S. Malarkey
Publikováno v:
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname
Acta Crystallographica Section D: Biological Crystallography
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname
Acta Crystallographica Section D: Biological Crystallography
The crystal structure of HMGB1 box A bound to an unmodified AT-rich DNA fragment is reported at a resolution of 2 Å. A new mode of DNA recognition for HMG box proteins is found in which two box A domains bind in an unusual configuration generating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432bbcff7de536e9afda500f145b6248
https://doi.org/10.1107/s1399004715007452
https://doi.org/10.1107/s1399004715007452
Publikováno v:
Trends in Biochemical Sciences. 37:553-562
High mobility group (HMG) box proteins are abundant and ubiquitous DNA binding proteins with a remarkable array of functions throughout the cell. The structure of the HMG-box DNA binding domain and general mechanisms of DNA binding and bending have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3467851f77f622db23a7dbb64c1f40de
https://doi.org/10.1016/j.tibs.2012.09.003
https://doi.org/10.1016/j.tibs.2012.09.003
Autor:
Raul M. Torres, Edward N. Janoff, Jessica Saifee, Claire E. Gustafson, Mair E. A. Churchill, Christopher S. Malarkey
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157157 (2016)
PLoS ONE, Vol 11, Iss 6, p e0157157 (2016)
Mitochondrial transcription factor A (TFAM) had previously been shown to act as a damage associated molecular pattern with the ability to enhance CpG-A phosphorothioate oligodeoxynucleotide (ODN)-mediated stimulation of IFNα production from human pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05652b52994ac181d03e248139907b3b
https://pubmed.ncbi.nlm.nih.gov/27280778
https://pubmed.ncbi.nlm.nih.gov/27280778
Autor:
Palmiro Cantatore, Claudia Lionetti, Christopher S. Malarkey, Paola Loguercio Polosa, Stefania Deceglie, Mair E. A. Churchill, Marina Roberti
Publikováno v:
Mitochondrion. 29
Mitochondrial transcription factor A (TFAM) is a key component for the protection and transcription of the mitochondrial genome. TFAM belongs to the high mobility group (HMG) box family of DNA binding proteins that are able to bind to and bend DNA. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30efe4d532bced9c325ac9c14c4f6ffb
https://pubmed.ncbi.nlm.nih.gov/27101895
https://pubmed.ncbi.nlm.nih.gov/27101895
Autor:
Gerald S. Shadel, Christopher S. Malarkey, Megan Bestwick, Jane E. Kuhlwilm, Mair E. A. Churchill
Publikováno v:
Nucleic Acids Research
Mitochondrial transcription factor A (mtTFA/TFAM) is a nucleus-encoded, high-mobility-group-box (HMG-box) protein that regulates transcription of the mitochondrial genome by specifically recognizing light-strand and heavy-strand promoters (LSP, HSP1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43191beae75ba85ac0c84b8f63e188b2
http://europepmc.org/articles/PMC3258160
http://europepmc.org/articles/PMC3258160
Autor:
Sarita Namjoshi, Jessica K. Tyler, Christopher S. Malarkey, Mair E. A. Churchill, Siddhartha Roy, Tatiana G. Kutateladze, David N. M. Jones, Chandrima Das
Publikováno v:
Proceedings of the National Academy of Sciences. 111
The multifunctional Creb-binding protein (CBP) protein plays a pivotal role in many critical cellular processes. Here we demonstrate that the bromodomain of CBP binds to histone H3 acetylated on lysine 56 (K56Ac) with higher affinity than to its othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bee6785dc8bd9090f4be4079241b9f2
https://doi.org/10.1073/pnas.1319122111
https://doi.org/10.1073/pnas.1319122111