Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher S. Kearn"'
Publikováno v:
The Journal of Comparative Neurology. 495:299-313
The nucleus accumbens (Acb) shell and core are essential components of neural circuitry mediating the reward and motor effects produced by activation of dopamine D2 or cannabinoid-1 (CB1) receptors. D2 receptors can form heterodimeric complexes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dae71cb41fcc7e13e89f47782e0859c
https://doi.org/10.1002/cne.20881
https://doi.org/10.1002/cne.20881
Autor:
Erica J. Carrier, Sachin Patel, Christopher S. Kearn, Maria A. Delgado, David J. Rademacher, Nicole M. Breese, Andrew J. Barkmeier, Cecilia J. Hillard, William B. Campbell, Kasem Nithipatikom, Sandra L. Pfister, David E. Klick
Publikováno v:
Journal of Neuroimmunology. 149:130-141
We have established a clonal cell line derived from rat microglia that proliferates in response to macrophage-colony stimulating factor (CSF-1). Like primary neonatal microglia, these cells (named RTMGL1) exhibit a ramified morphology, bind isolectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dd6e5a4000997833fb035faf7051b7
https://doi.org/10.1016/j.jneuroim.2003.12.022
https://doi.org/10.1016/j.jneuroim.2003.12.022
Autor:
Christopher S. Kearn, Andrew J. Barkmeier, Cecilia J. Hillard, Wenqi Yang, Erica J. Carrier, Nicole M. Breese, William B. Campbell, Kasem Nithipatikom, Sandra L. Pfister
Publikováno v:
Molecular Pharmacology. 65:999-1007
Microglia, as phagocytes and antigen-presenting cells in the central nervous system, are activated in such disease processes as stroke and multiple sclerosis. Because peripheral macrophages are capable of producing endocannabinoids, we have examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8ed6fbd0fd5073bccd81430440a36a
https://doi.org/10.1124/mol.65.4.999
https://doi.org/10.1124/mol.65.4.999
Autor:
William B. Campbell, Cecilia J. Hillard, Christopher S. Kearn, John R. Falck, William S. Edgemond
Publikováno v:
Molecular Pharmacology. 54:180-188
Arachidonylethanolamide (AEA), the putative endogenous ligand of the cannabinoid receptor, has been shown to be a substrate for lipoxygenase enzymes in vitro. One goal of this study was to determine whether lipoxygenase-rich cells metabolize AEA. [14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f81102a221edd7a7f9ac4c9c19483f
https://doi.org/10.1124/mol.54.1.180
https://doi.org/10.1124/mol.54.1.180
Autor:
Simon J. O'Carroll, A. Bhalla, Lawrence W. Chamley, Michelle Glass, Peter Stone, H.S. Liddell, Christopher S. Kearn
Publikováno v:
Placenta. 29(11)
Endocannabiniods are lipid signalling molecules that are related to the major psychoactive component in marijuana, delta-9-tetrahydrocannabinol and are increasingly recognized as being important in implantation and development of early embryos. The e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7265a4b7597f591ebba1ebeda823b219
https://pubmed.ncbi.nlm.nih.gov/18805581
https://pubmed.ncbi.nlm.nih.gov/18805581
Publikováno v:
Neuroscience. 152(1)
Rearing rats in isolation has been shown to produce behavioral and neurochemical alterations similar to those observed in psychoses such as schizophrenia. Also, a dysregulation in both the endocannabinoid and dopaminergic systems has been implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2fc7a3a9806de4717a76a50942f798
https://pubmed.ncbi.nlm.nih.gov/18082330
https://pubmed.ncbi.nlm.nih.gov/18082330
Publikováno v:
Molecular pharmacology. 67(5)
Dopamine and endogenous cannabinoids display complex interactions in the basal ganglia. One possible level of interaction is between CB1 cannabinoid and D2 dopamine receptors. Here, we demonstrate that a regulated association of CB1 and D2 receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e895aff19e2798a4b878cff63c597e1
https://pubmed.ncbi.nlm.nih.gov/15710746
https://pubmed.ncbi.nlm.nih.gov/15710746
Autor:
Lawrence W. Chamley, Michelle Glass, Murray D. Mitchell, Katherine Blake-Palmer, Janice Wu, Rachel J. A. Helliwell, Christopher S. Kearn
Publikováno v:
The Journal of clinical endocrinology and metabolism. 89(10)
In recent years, it has been demonstrated that high circulating levels of the endogenous cannabinoid anandamide, resulting from low expression of its metabolizing enzyme fatty acid amide hydrolase (FAAH), may contribute to spontaneous miscarriage and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d88bb09b0acf14115df81ea5365a94
https://pubmed.ncbi.nlm.nih.gov/15472222
https://pubmed.ncbi.nlm.nih.gov/15472222
Autor:
Ralph F. DiCamelli, Christopher S. Kearn, Kristen Kurzawa, Marcie J. Greenberg, Cecilia J. Hillard
Publikováno v:
Journal of neurochemistry. 72(6)
The hypothesis of these studies is that ligand efficacy at the neuronal CB1 receptor is dependent on the ratio of ligand affinities for the active and inactive states of the receptor. Agonist efficacy was determined in rat cerebellar membranes using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea255a013a0fa88521b8b6118d87dc4
https://pubmed.ncbi.nlm.nih.gov/10349847
https://pubmed.ncbi.nlm.nih.gov/10349847
Publikováno v:
FEBS Letters. (2):277-281
Cerebellar granule cells (CGCs) express the CB(1) subtype of cannabinoid receptor. CB(1) receptor agonists Win 55212-2, CP55940 and HU210 inhibit KCl-induced activation of nitric oxide synthase (NOS) in CGCs. Win 55212-2 has no effect on either basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db05264ccc751a2474d4f84924b47fe