Výsledky vyhledávání - "Christopher S. Jetter"

Akademický článek

Alveolar repair following LPS-induced injury requires cell-ECM interactions

Autor: Jennifer M.S. Sucre, Fabian Bock, Nicholas M. Negretti, John T. Benjamin, Peter M. Gulleman, Xinyu Dong, Kimberly T. Ferguson, Christopher S. Jetter, Wei Han, Yang Liu, Seunghyi Kook, Jason J. Gokey, Susan H. Guttentag, Jonathan A. Kropski, Timothy S. Blackwell, Roy Zent, Erin J. Plosa

Publikováno v: JCI Insight, Vol 8, Iss 14 (2023)

During alveolar repair, alveolar type 2 (AT2) epithelial cell progenitors rapidly proliferate and differentiate into flat AT1 epithelial cells. Failure of normal alveolar repair mechanisms can lead to loss of alveolar structure (emphysema) or develop

Externí odkaz: https://doaj.org/article/39a9e420f73c4111974b87e317b6ae4c

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Akademický článek

Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters

Autor: Ran eYe, Meagan A. Quinlan, Hideki eIwamoto, Hsiao-Huei eWu, Noah H. Green, Christopher S. Jetter, Douglas G. McMahon, Jeremy eVeenstra-VanderWeele, Pat R. Levitt, Randy D. Blakely

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 7 (2016)

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) modulates many key brain functions including those subserving sensation, emotion, reward and cognition. Efficient clearance of 5-HT after release is achieved by the antidepressant-sensitive 5

Externí odkaz: https://doaj.org/article/a6b5edfe4cb1437ea1562d158f0abbf8

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Developmental trajectory of extracellular vesicle characteristics from the lungs of preterm infants

Autor: Meaghan A. Ransom, Kaitlyn E. Bunn, Nicholas M. Negretti, Christopher S. Jetter, Zachary J. Bressman, Jennifer M. S. Sucre, Heather H. Pua

Publikováno v: Am J Physiol Lung Cell Mol Physiol

Extracellular vesicles (EVs) are secreted lipid-enclosed particles that have emerged as potential biomarkers and therapeutic agents in lung disease, including bronchopulmonary dysplasia (BPD), a leading complication of preterm birth. Many unanswered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d526fe60ae2549deeded546251d13f08
https://europepmc.org/articles/PMC10026990/

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A single-cell atlas of mouse lung development

Autor: Nicholas M. Negretti, Erin J. Plosa, John T. Benjamin, Bryce A. Schuler, A. Christian Habermann, Christopher S. Jetter, Peter Gulleman, Claire Bunn, Alice N. Hackett, Meaghan Ransom, Chase J. Taylor, David Nichols, Brittany K. Matlock, Susan H. Guttentag, Timothy S. Blackwell, Nicholas E. Banovich, Jonathan A. Kropski, Jennifer M. S. Sucre

Publikováno v: Development

Lung organogenesis requires precise timing and coordination to effect spatial organization and function of the parenchymal cells. To provide a systematic broad-based view of the mechanisms governing the dynamic alterations in parenchymal cells over c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0071bc69a1fd8bc9e9d363891b2f1ac2
https://europepmc.org/articles/PMC8722390/

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Single-cell transcriptomic assessment of cellular phenotype stability in human precision-cut lung slices

Autor: Austin J. Gutierrez, Jonathan A. Kropski, Jason J. Gokey, Christopher S. Jetter, Chase J. Taylor, Jane E. Camarata, Nicholas E. Banovich, Linh T. Bui, Matthew Bacchetta, Nichelle I. Winters, Jennifer M.S. Sucre

Precision-cut lung slices (PCLS) are increasingly utilized for ex vivo disease modeling, but a high-resolution characterization of cellular phenotype stability in PCLS has not been reported. Comparing the single-cell transcriptomic profile of human P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ff624c3f4d79b8d909c4fa3bfbbb0c
https://doi.org/10.1101/2021.08.19.457016

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AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells

Autor: Shufang Meng, Alexa Jaume, Christopher S. Jetter, Ping Wang, Jason J. Gokey, John T. Benjamin, Jennifer M.S. Sucre, Hayley A. Hanby, Michael S. Marks, Seunghyi Kook, Susan H. Guttentag, Laura Goetzl

Publikováno v: Proc Natl Acad Sci U S A

Lamellar bodies (LBs) are lysosome-related organelles (LROs) of surfactant-producing alveolar type 2 (AT2) cells of the distal lung epithelium. Trafficking pathways to LBs have been understudied but are likely critical to AT2 cell homeostasis given a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9343c1e9403e7d8dc8bff9e9549ee6d
https://pubmed.ncbi.nlm.nih.gov/33990468

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