Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christopher S Lunde"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011795 (2023)
Burkholderia pseudomallei is the causative agent of melioidosis, which is increasingly being reported worldwide. Mortality rates as high as 40% have been reported based on clinical patient outcomes in the endemic areas of Australia and Thailand. Nove
Externí odkaz:
https://doaj.org/article/507864f1f55e4eee9340ff09864717bb
Autor:
Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that ta
Externí odkaz:
https://doaj.org/article/dec6d4c0192a4b7f912f2690a17c0fac
Autor:
Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, Md Mahmudul Hasan, Peter Miller, John Barlow, Yvonne R. Freund, Pamela Berry, Rianna Stefanakis, Jiri Gut, Philip J. Rosenthal, Melissa S. Love, Case W. McNamara, Eric Easom, Jacob J. Plattner, Robert T. Jacobs, Christopher D. Huston
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite de
Externí odkaz:
https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7
Autor:
Robert T. Jacobs, Rianna Stefanakis, Nancy Tricoche, Eric E. Easom, Yvonne Freund, Kee Chong Lim, James H. McKerrow, David S. Carter, Christina A. Bulman, Brian M. Suzuki, Christopher S. Lunde, Pamela Berry, Judy A. Sakanari, Jacob J. Plattner, Chelsea Fischer, Sara Lustigman, Tsutomu Akama, Fernando Rock
Publikováno v:
ACS Infectious Diseases
The optimization of a series of benzimidazole–benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beee7fb4c5ebfd7c32f697f2a5ce9791
https://doi.org/10.1021/acsinfecdis.9b00397
https://doi.org/10.1021/acsinfecdis.9b00397
Autor:
Rianna Stefanakis, Eric E. Easom, Jacob J. Plattner, Yvonne Freund, Erin E. Stebbins, Melissa S. Love, Pamela Berry, Jiri Gut, Christopher D. Huston, Rajiv S. Jumani, Case W. McNamara, Philip J. Rosenthal, Peter J. Miller, Christopher S. Lunde, Robert T. Jacobs, John W. Barlow, Mahmudul Hasan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children and causes chronic diarrhea in AIDS patients, but the only approved treatment is ineffective in malnourished children and immunocompromised people. We here use a drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32813dbe54d00c74f148ff27329f781
https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7
https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7
Autor:
Tsutomu Akama, Yvonne R. Freund, Pamela W. Berry, David S. Carter, Eric E. Easom, Kurt Jarnagin, Christopher S. Lunde, Jacob J. Plattner, Fernando Rock, Rianna Stefanakis, Chelsea Fischer, Christina A. Bulman, Kee Chong Lim, Brian M. Suzuki, Nancy Tricoche, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, Ben Carson, John W. McCall, James McKerrow, Marc P. Hübner, Sabine Specht, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari, Robert T. Jacobs
Publikováno v:
ACS Infectious Diseases
A series of benzimidazole–benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good in vitro activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cc683f66d1ab3829297dad3581ff3c
https://pubmed.ncbi.nlm.nih.gov/31876154
https://pubmed.ncbi.nlm.nih.gov/31876154
Autor:
Christopher S. Lunde, Martina Fendler, Xianfeng Li, Joseph D. Turner, Mark J. Taylor, Marianne Koschel, Marc P. Hübner, Alexandra Ehrens, Dominique Struever, Robert T. Jacobs, Franziska Lenz, Stefan J. Frohberger, Achim Hoerauf, Eric E. Easom, Yvonne Freund, Stephen A. Ward, Jacob J. Plattner, Rianna Stefanakis
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal–adult worm killing–drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93bb93720e40d8a7a8b1031df65f76a
https://doi.org/10.1371/journal.pntd.0007957
https://doi.org/10.1371/journal.pntd.0007957
Autor:
Shahab Rouhani, Yong Duan, Ayla O Sessions, Christopher S. Lunde, Ting Wang, Marc T. Facciotti, Robert M. Glaeser
Publikováno v:
Structure. 21(2):290-297
Summary Despite extensive investigation, the precise mechanism controlling the opening of the cytoplasmic proton uptake pathway in bacteriorhodopsin (bR) has remained a mystery. From an analysis of the X-ray structure of the D96G/F171C/F219L triple m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f172b9b602906d15a43954ae5689b5a
Publikováno v:
Journal of Applied Crystallography. 41:483-486
A simple and flexible system is described forin situscreening of microcrystals of membrane proteins that are grown within a connected-bilayer matrix formed by hydrated lipids. Using sheets of appropriate polymer materials to create a thin multiwell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c578fb845e9a5ee3f55c6dab419a7c3
https://doi.org/10.1107/s0021889808000952
https://doi.org/10.1107/s0021889808000952
Autor:
Jonathan P Remis, Robert M. Glaeser, Christopher S. Lunde, Steven E. Ruzin, James A. Ernst, Shahab Rouhani
Publikováno v:
Journal of Applied Crystallography. 38:1031-1034
This paper describes the relatively simple modification of a light microscope to operate with ultraviolet-based optics. Using a 280 nm UV illumination source, protein microcrystals are readily visualized in gels made from hydrated bilayers of phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149d9cf83ac2e04c8220b831bf352f72
https://doi.org/10.1107/s0021889805028888
https://doi.org/10.1107/s0021889805028888