Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christopher S Konkoy"'
Autor:
Giacomo Ruotolo, Stuart Friedrich, Ellen A. Cannady, Kathryn A. Krueger, Jeffrey G. Suico, Christopher S Konkoy, Ming-Dauh Wang
Publikováno v:
The Journal of Pharmacy and Pharmacology
Objectives We investigated the safety, tolerability, pharmacokinetics and pharmacodynamics of evacetrapib. Methods Healthy volunteers received multiple daily doses of evacetrapib (10–600 mg) administered for up to 15 days in a placebo-controlled st
Autor:
Matthias Herz, Christopher S Konkoy, Don Johns, M. H. Tan, Jan W. Eriksson, J Halse, Sten Madsbad, J Clausen, J Strand
Publikováno v:
Diabetic Medicine. 21:859-866
This study compared the effects of 52 weeks' treatment with pioglitazone, a thiazolidinedione that reduces insulin resistance, and glibenclamide, on insulin sensitivity, glycaemic control, and lipids in patients with Type 2 diabetes.Patients with Typ
Autor:
Edward R. Whittemore, Minhtam Tran, David Rock, Richard M. Woodward, Zhang-Lin Zhou, Sui Xiong Cai, Christopher S. Konkoy, Stephen A. Espitia, Lawrence D. Wise, Christopher F. Bigge, John F. W. Keana, Jon E. Hawkinson, Eckard Weber, Peter A. Boxer, Linda L. Coughenour
Publikováno v:
Journal of Medicinal Chemistry. 42:2993-3000
A structure-based search and screen of our compound library identified N-(2-phenoxyethyl)-4-benzylpiperidine (8) as a novel N-methyl-D-aspartate (NMDA) receptor antagonist that has high selectivity for the NR1/2B subunit combination (IC(50) = 0.63 mi
Autor:
Richard M. Woodward, Eckard Weber, Richard B. Carter, John F. W. Keana, Victor I. Ilyin, Kimberly E. Vanover, Sui Xiong Cai, Yan Wang, Christopher S. Konkoy
Publikováno v:
Journal of Medicinal Chemistry. 41:2621-2625
A group of 7,8-(methylenedioxy)-1-phenyl-3,5-dihydro-4H-2, 3-benzodiazepin-4-ones was synthesized and assayed for antagonism of rat brain alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors expressed in Xenopus oocytes. The benz
Autor:
Thomas P. Davis, Christopher S. Konkoy
Publikováno v:
Trends in Pharmacological Sciences. 17:288-294
The ectoenzyme-mediated metabolism of neuropeptides may be an important regulatory site of peptide-mediated activity. These membrane-bound, extracellularly oriented peptidases are not only responsible for inactivating peptide substrates, but also lea
Chronic treatment with neuroleptics alters neutral endopeptidase 24.11 activity in rat brain regions
Publikováno v:
Peptides. 14:1017-1020
Chronic administration of neuroleptics has been shown to affect the endogenous levels, mRNA, posttranslational processing, and metabolism of neuropeptides in specific regions of rat brain. Neutral endopeptidase 24.11 (NEP) is known to metabolize a va
Autor:
Joseph A. Jakubowski, Nagy A. Farid, Christopher S Konkoy, Christopher D. Payne, Daniel E. Salazar, David S. Small, Kenneth J. Winters
Publikováno v:
Clinical pharmacokinetics. 49(12)
Thienopyridines are inactive prodrugs that are converted in vivo to active metabolites, which irreversibly bind to and inactivate platelet P2Y12 receptors, and inhibit platelet activation and aggregation. Prasugrel is a third-generation thienopyridin
Autor:
Richard M. Woodward, Edward R. Whittemore, Kevin A. Serpa, Lawrence D. Wise, Christopher S. Konkoy, Tracy F. Gregory, Jon Wright, Leonard T. Meltzer
Publikováno v:
ChemInform. 31
A series of 1-(heteroarylthioalkyl)-4-benzylpiperidines was rapidly synthesized through the use of parallel synthesis to investigate the binding affinity for the NR1 a /2B receptor subtype.
Autor:
Jon Wright, Lawrence D. Wise, Christopher S. Konkoy, Kevin A. Serpa, Richard M. Woodward, Leonard T. Meltzer, Tracy F. Gregory, Edward R. Whittemore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:527-529
A series of 1-(heteroarylthioalkyl)-4-benzylpiperidines was rapidly synthesized through the use of parallel synthesis to investigate the binding affinity for the NR1 a /2B receptor subtype.
Autor:
Joseph A. Jakubowski, Christopher D. Payne, Nagy A. Farid, John T. Brandt, C. Steven Ernest, David S. Small, Daniel E. Salazar, Christopher S Konkoy, Kenneth J. Winters, Ying G. Li
Publikováno v:
Pharmacotherapy. 28(12)
Study Objective. To investigate the potential effect of atorvastatin 80 mg/day on the pharmacokinetics and pharmacodynamics of the thienopyridines prasugrel and clopidogrel. Design. Open-label, randomized, crossover, two-arm, parallel-group study. Se