Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Christopher S Ahn"'
Autor:
Leonithas I Volakis, Ruth Li, William E Ackerman, Cosmin Mihai, Meagan Bechel, Taryn L Summerfield, Christopher S Ahn, Heather M Powell, Rachel Zielinski, Thomas J Rosol, Samir N Ghadiali, Douglas A Kniss
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86110 (2014)
Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal transition (EMT) and migrate as single cells. Epithelial tumor cells may also migrate in a highl
Externí odkaz:
https://doaj.org/article/3d2c61869897490db838cece07bd8fd7
Autor:
Trey Ideker, Prashant Mali, Roman Sasik, Christian M. Metallo, Jens Luebeck, Christopher S. Ahn, Jose H. Magana, Mehmet G. Badur, Amanda Birmingham, Dongxin Zhao
Publikováno v:
Molecular cell, vol 69, iss 4
The metabolic pathways fueling tumor growth have been well characterized, but the specific impact of transforming events on network topology and enzyme essentiality remains poorly understood. To this end, we performed combinatorial CRISPR-Cas9 screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6773fac19229fb6e230f47da570a6f35
https://doi.org/10.1016/j.molcel.2018.01.017
https://doi.org/10.1016/j.molcel.2018.01.017
Autor:
Thekla Cordes, Elias A. Castilla, Angeles Duran, Jorge Moscat, Christian M. Metallo, Maria T. Diaz-Meco, Juan F. Linares, Christopher S. Ahn, Miguel Reina-Campos, Tania Valencia
Publikováno v:
Cell Metabolism. 26:817-829.e6
Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The stroma may play a critical role in this process by providing nutrients to support the epithelial compartment of the tumor. Here we show that p62 deficiency in strom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a910f7ba51fd47d584fb9257a688224
https://doi.org/10.1016/j.cmet.2017.09.001
https://doi.org/10.1016/j.cmet.2017.09.001
Autor:
Jorge Moscat, Maria T. Diaz-Meco, Tania Valencia, Christian M. Metallo, Juan F. Linares, Christopher S. Ahn, Angeles Duran
Publikováno v:
Cancer Research. 75:SY01-02
Cancer is the result of the stepwise acquisition of genetic alterations within the epithelial compartment. However, recent data supports the relevance of the tumor microenvironment in the control of cancer progression. Central to this process is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfb10cf32ac7996a5eb1241f8e9d7475
https://doi.org/10.1158/1538-7445.am2015-sy01-02
https://doi.org/10.1158/1538-7445.am2015-sy01-02
Autor:
William E. Ackerman, Heather M. Powell, Rachel Zielinski, Cosmin Mihai, Douglas A. Kniss, Taryn Summerfield, Thomas J. Rosol, Christopher S. Ahn, Meagan Bechel, Ruth Li, Samir N. Ghadiali, Leonithas I. Volakis
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86110 (2014)
PLoS ONE
PLoS ONE
Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal transition (EMT) and migrate as single cells. Epithelial tumor cells may also migrate in a highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0511d3d115ce83ef9f8a62f2f3c7858c
https://doi.org/10.1371/journal.pone.0086110
https://doi.org/10.1371/journal.pone.0086110
Autor:
Christian M. Metallo, Maria T. Diaz-Meco, Tania Valencia, Miguel Reina-Campos, Jorge Moscat, Elias A. Castilla, Jorge Moscat-Pardos, Angeles Duran, Ji Young Kim, Christopher S. Ahn, Shadi Abu-Baker
Publikováno v:
Cancer cell, vol 26, iss 1
Valencia, T; Kim, JY; Abu-Baker, S; Moscat-Pardos, J; Ahn, CS; Reina-Campos, M; et al.(2014). Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis. CANCER CELL, 26(1), 121-135. doi: 10.1016/j.ccr.2014.05.004. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4xb9f4pz
Valencia, T; Kim, JY; Abu-Baker, S; Moscat-Pardos, J; Ahn, CS; Reina-Campos, M; et al.(2014). Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis. CANCER CELL, 26(1), 121-135. doi: 10.1016/j.ccr.2014.05.004. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4xb9f4pz
SummaryThe tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms by which stromal cells influence the epithelium are poorly understood. Here we show that p62 levels were reduced in the stroma of several tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ea9c6d23e3d5d77e6fffb1d43207d8