Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Christopher S, Walker"'
Autor:
Tayla A. Rees, Benjamin J. Buttle, Zoe Tasma, Sung-Hyun Yang, Paul W. R. Harris, Christopher S. Walker
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Type 2 diabetes (T2D) and obesity are prevalent metabolic disorders affecting millions of individuals worldwide. A new effective therapeutic drug called tirzepatide for the treatment of obesity and T2D is a dual agonist of the GIP receptor and GLP-1
Externí odkaz:
https://doaj.org/article/0907ffccbaea49f58081214071b5e048
Autor:
Tayla A. Rees, Zoe Tasma, Michael L. Garelja, Simon J. O’Carroll, Christopher S. Walker, Debbie L. Hay
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background The upper cervical dorsal root ganglia (DRG) are important for the transmission of sensory information associated with the back of the head and neck, contributing to head pain. Calcitonin receptor (CTR)-based receptors, such as th
Externí odkaz:
https://doaj.org/article/08f9f4a08dc545469ba5b337cb58b3af
CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The neuropeptide calcitonin gene-related peptide (CGRP) is expressed in the trigeminal ganglia, a key site in craniofacial pain and migraine. CGRP potently activates two receptors: the CGRP receptor and the AMY1 receptor. These receptors are heterodi
Externí odkaz:
https://doaj.org/article/d54d4faa3d324cc1b9aae6209d9a0faa
Autor:
Aqfan Jamaluddin, Chia-Lin Chuang, Elyse T. Williams, Andrew Siow, Sung Hyun Yang, Paul W. R. Harris, Jakeb S. S. M. Petersen, Rebekah L. Bower, Shanan Chand, Margaret A. Brimble, Christopher S. Walker, Debbie L. Hay, Kerry M. Loomes
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as an
Externí odkaz:
https://doaj.org/article/087bc21e011f479b87b8311010e81136
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1058 (2023)
We read with great interest the recent article by Yoo and colleagues [...]
Externí odkaz:
https://doaj.org/article/946b63b573ae4bcd84655418f06244de
Autor:
Erica R. Hendrikse, Tayla A. Rees, Zoe Tasma, Michael L. Garelja, Andrew Siow, Paul W. R. Harris, John B. Pawlak, Kathleen M. Caron, Elizabeth S. Blakeney, Andrew F. Russo, Levi P. Sowers, Thomas A. Lutz, Christelle Le Foll, Christopher S. Walker, Debbie L. Hay
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16035 (2022)
Calcitonin gene-related peptide (CGRP) is a key component of migraine pathophysiology, yielding effective migraine therapeutics. CGRP receptors contain a core accessory protein subunit: receptor activity-modifying protein 1 (RAMP1). Understanding of
Externí odkaz:
https://doaj.org/article/19f20e794c5043bbab5b71049db7d12b
Autor:
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Simon J. O’Carroll, Debbie L. Hay, Christopher S. Walker
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13797 (2022)
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide expressed in the trigeminal ganglia (TG). The TG conducts nociceptive signals in the head and may play roles in migraine. PACAP infusion provokes headaches in healthy individual
Externí odkaz:
https://doaj.org/article/3c985c4848b547de8c5767f2450c441c
Autor:
Tyla I. Alexander, Zoe Tasma, Andrew Siow, Tayla A. Rees, Margaret A. Brimble, Paul W. R. Harris, Debbie L. Hay, Christopher S. Walker
Publikováno v:
ACS Pharmacology & Translational Science. 6:52-64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dccafed1ec8a6d867d75381db0f5abb4
https://doi.org/10.1021/acsptsci.2c00124
https://doi.org/10.1021/acsptsci.2c00124
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The “gepants” are a class of calcitonin gene-related peptide (CGRP) receptor antagonist molecules that have been developed for the prevention and treatment of migraine. Rimegepant is reported to act at the CGRP receptor, has good oral bioavailabi
Externí odkaz:
https://doaj.org/article/d21dc98e2ed94656b208842d52597af6
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 3, Pp n/a-n/a (2020)
Abstract The corticotropin‐releasing factor (CRF) receptors represent potential drug targets for the treatment of anxiety, stress, and other disorders. However, it is not known if endogenous CRF receptor agonists display biased signaling, how effec
Externí odkaz:
https://doaj.org/article/b29a520c46634826a2ad66da9d07a8a8