Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Christopher S, Fry"'
Autor:
Andrea L. Dimet-Wiley, Christine M. Latham, Camille R. Brightwell, Harshini Neelakantan, Alexander R. Keeble, Nicholas T. Thomas, Haley Noehren, Christopher S. Fry, Stanley J. Watowich
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising
Externí odkaz:
https://doaj.org/article/bd2c80f1e7bf42fd9e877971c7a909b7
Autor:
R Clay Bunn, Reuben Adatorwovor, Rebecca R Smith, Philip D Ray, Sarah E Fields, Alexander R Keeble, Christopher S Fry, Sasidhar Uppuganti, Jeffry S Nyman, John L Fowlkes, Evangelia Kalaitzoglou
Publikováno v:
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023)
ABSTRACT Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk, and impaired skeletal muscle function. Myostatin, a myokine that is systemically elevated in humans with T1D, negatively regulates muscle mass and bo
Externí odkaz:
https://doaj.org/article/92100dade6de4c38b7555d341607541a
Autor:
Jean L. Fry, Brooke D. Munson, Katherine L. Thompson, Christopher S. Fry, Douglas Paddon-Jones, Emily J. Arentson-Lantz
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to p
Externí odkaz:
https://doaj.org/article/8c4c79889e6241089d04dcf6139d8023
Publikováno v:
Frontiers in Sports and Active Living, Vol 4 (2023)
Exercise performance is dependent on many factors, such as muscular strength and endurance, cardiovascular capacity, liver health, and metabolic flexibility. Recent studies show that plasma levels of bilirubin, which has classically been viewed as a
Externí odkaz:
https://doaj.org/article/3835ac39877543ad929295403fae7b91
Autor:
Michael S. Borack, Jared M. Dickinson, Christopher S. Fry, Paul T. Reidy, Melissa M. Markofski, Rachel R. Deer, Kristofer Jennings, Elena Volpi, Blake B. Rasmussen
Publikováno v:
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Previous work in HEK-293 cells demonstrated the importance of amino acid-induced mTORC1 translocation to the lysosomal surface for stimulating mTORC1 kinase activity and protein synthesis. This study tested the conservation of thi
Externí odkaz:
https://doaj.org/article/3a713d11a58f498f85e33400471fcb59
Autor:
Camille R. Brightwell, Ameya S. Kulkarni, William Paredes, Kehao Zhang, Jaclyn B. Perkins, Knubian J. Gatlin, Matthew Custodio, Hina Farooq, Bushra Zaidi, Rima Pai, Rupinder S. Buttar, Yan Tang, Michal L. Melamed, Thomas H. Hostetter, Jeffrey E. Pessin, Meredith Hawkins, Christopher S. Fry, Matthew K. Abramowitz
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
BACKGROUND Skeletal muscle maladaptation accompanies chronic kidney disease (CKD) and negatively affects physical function. Emphasis in CKD has historically been placed on muscle fiber–intrinsic deficits, such as altered protein metabolism and atro
Externí odkaz:
https://doaj.org/article/28e2b2ab95fc4aababe1574c610d359a
Autor:
Marie Mortreux, Megan E. Rosa‐Caldwell, Ian D. Stiehl, Dong‐Min Sung, Nicholas T. Thomas, Christopher S. Fry, Seward B. Rutkove
Publikováno v:
Physiological Reports, Vol 9, Iss 19, Pp n/a-n/a (2021)
Abstract Ground‐based animal models have been used extensively to understand the effects of microgravity on various physiological systems. Among them, hindlimb suspension (HLS), developed in 1979 in rats, remains the gold‐standard and allows rese
Externí odkaz:
https://doaj.org/article/d01f2d5fd0b54dcb9043a8cc932cd0c0
Autor:
Victoria G. Rontoyanni, Elizabeth Blears, Omar Nunez Lopez, John Ogunbileje, Tatiana Moro, Nisha Bhattarai, Amanda C. Randolph, Christopher S. Fry, Grant T. Fankhauser, Zulfiqar F. Cheema, Andrew J. Murton, Elena Volpi, Blake B. Rasmussen, Porter Craig
Publikováno v:
Journal of Surgical Research. 288:108-117
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1086f9b6407a5acef19080bfba80b8bd
https://doi.org/10.1016/j.jss.2023.02.015
https://doi.org/10.1016/j.jss.2023.02.015
Autor:
Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evi
Externí odkaz:
https://doaj.org/article/0bc07f083e994c3a999d215e49a6bcfe
Autor:
Kevin A. Murach, Bailey D. Peck, Robert A. Policastro, Ivan J. Vechetti, Douglas W. Van Pelt, Cory M. Dungan, Lance T. Denes, Xu Fu, Camille R. Brightwell, Gabriel E. Zentner, Esther E. Dupont-Versteegden, Christopher I. Richards, Jeramiah J. Smith, Christopher S. Fry, John J. McCarthy, Charlotte A. Peterson
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102372- (2021)
Summary: Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking, satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show satellite cells communicate with other cells in skeletal m
Externí odkaz:
https://doaj.org/article/bf5d536bcc1c44ae96a88fbbda14f370