Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christopher Rowbottom"'
Autor:
Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, Richard Grater, Daniel Qiu, Sudarshan Kapadnis, Patrick Trapa
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method
Externí odkaz:
https://doaj.org/article/103f00bec9d940f988399c1ce77485f6
Autor:
Sudarshan Kapadnis, Patrick Trapa, Richard Grater, Daniel Qiu, Taras Tuczewycz, Christopher Rowbottom, Alicia Pietrasiewicz
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a2ee10faed30def67aa2b2127bd820
http://europepmc.org/articles/PMC7931226
http://europepmc.org/articles/PMC7931226
Autor:
Sarah Billington, Caroline A. Lee, Anita Mathias, W. Griffith Humphreys, Guangqing Xiao, Adrian S. Ray, Xiaoyan Chu, Edward J. Kelly, Raymond Evers, Laurent Salphati, Cornelis E. C. A. Hop, Christopher Rowbottom, Bhagwat Prasad, Mingxiang Liao, Yurong Lai, Jashvant D. Unadkat
Publikováno v:
Drug Metabolism and Disposition. 46:189-196
Protein expression of major hepatobiliary drug transporters (NTCP, OATPs, OCT1, BSEP, BCRP, MATE1, MRPs, and P-gp) in cancerous (C, n = 8) and adjacent noncancerous (NC, n = 33) liver tissues obtained from patients with chronic hepatitis C with hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4736f22e3b5a832e687ab271915d84d9
https://doi.org/10.1124/dmd.117.077289
https://doi.org/10.1124/dmd.117.077289
Autor:
Markus Warmuth, Manav Korpal, Deepti Banka, Peter Fekkes, Pavan Kumar, Andrew Hart, Lihua Yu, Ping Zhu, Lorna Helen Mitchell, Joyce Yang, W. George Lai, Amy Kim, Craig Karr, Pete Smith, Tarek Sahmoud, Xiaoling Puyang, Sherri Smith, Mike Thomas, Benjamin Caleb, O'shea Morgan Welzel, Victoria Rimkunas, Huilan Yao, Sean Eckley, Allison Davis, Silvia Buonamici, Crystal MacKenzie, V. Subramanian, Jeremy Wu, Zheng Guo Zhu, Christopher Rowbottom, Reynolds Dominic, Nicholas A. Larsen, Nathalie Rioux, Sean Irwin, Craig Furman
Publikováno v:
Cancer Research. 77:DDT01-04
Mutations in the estrogen receptor (ER) are detected in up to 30% of patients that initially respond but subsequently relaps to anti-endocrine therapies. ERα mutations, likely through constitutively activating ERα, can functionally confer resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b5b0fa7e9d8e6795b2dcf66171548d
https://doi.org/10.1158/1538-7445.am2017-ddt01-04
https://doi.org/10.1158/1538-7445.am2017-ddt01-04
Autor:
Jashvant D. Unadkat, Cornelis E. C. A. Hop, Scott Heyward, Laurent Salphati, Nóra Szilvásy, Mingxiang Liao, Yurong Lai, Vineet Kumar, Anita Mathias, Beáta Tóth, Kazuya Ishida, Xiaoyan Chu, Guangqing Xiao, Christopher Rowbottom, W. Griffith Humphreys
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S61-S62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0511bc12644be051bdb7362da2358baa
https://doi.org/10.1016/j.dmpk.2020.04.130
https://doi.org/10.1016/j.dmpk.2020.04.130
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S23-S24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5124aa614456b1c62426918ac6023e0
https://doi.org/10.1016/j.dmpk.2020.04.004
https://doi.org/10.1016/j.dmpk.2020.04.004
Autor:
Alicia Pietrasiewicz, Taras Tuczkewycz, Sudarshan Kapadnis, Richard Grater, Christopher Rowbottom, Daniel Qiu, Doug Burdette, Elvana Viezaj
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f472d5a0170797247e4fe2e3cc05658
https://doi.org/10.1016/j.dmpk.2020.04.132
https://doi.org/10.1016/j.dmpk.2020.04.132
Autor:
Jashvant D. Unadkat, Bhagwat Prasad, Guangqing Xiao, Raymond Evers, W. Griffith Humphreys, Christopher Rowbottom, Cornelis E. C. A. Hop, Doug Burdette, Xiaoyan Chu, Tot Bui Nguyen, Yurong Lai, Laurent Salphati, Sarah Billington
Publikováno v:
Clinical pharmacology and therapeutics. 106(1)
For in vitro to in vivo extrapolation (IVIVE) of brain distribution of drugs that are transported at the human blood-brain barrier (BBB), it is important to quantify the interindividual and regional variability of drug transporter abundance at this b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80018276bc1b44813f2b6b39f15a8216
https://pubmed.ncbi.nlm.nih.gov/30673124
https://pubmed.ncbi.nlm.nih.gov/30673124
Publikováno v:
Pharmaceutical Research. 35
The renal clearance of fampridine (Fampyra®, or Ampyra®) significantly exceeds the glomerular filtration rate, suggesting active renal secretion is likely the major elimination pathway. The goal of this study was to identify the renal transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5d756f1bd2aab2a59c9772865b9d50
https://doi.org/10.1007/s11095-018-2445-y
https://doi.org/10.1007/s11095-018-2445-y
Autor:
Christopher Rowbottom, Mingxiang Liao, Scott Heyward, Laigao Chen, Xiaoyan Chu, Cornelis E. C. A. Hop, Yurong Lai, Guangqing Xiao, Beáta Tóth, Jashvant D. Unadkat, Viktória Juhász, Vineet Kumar, W. Griffith Humphreys, Anita Mathias, Laurent Salphati
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S22-S23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a31b3ef3c16804b5b3bb8b61f5f14d9
https://doi.org/10.1016/j.dmpk.2018.09.094
https://doi.org/10.1016/j.dmpk.2018.09.094