Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christopher Roland Wellaway"'
Autor:
Patricia F Medeiros, Mythily Vimal, Vipulkumar Kantibhai Patel, John Evans, Neil R Carlson, Antonia J. Lewis, Paul Bamborough, Katherine L Jones, Jane E Smith, Michael O'Sullivan, Scott McCleary, Darren J. Mitchell, Heather Barnett, Chun-wa Chung, Gang Yao, Anthony W. J. Cooper, Rab K. Prinjha, Laurie Gordon, Mahnoor Mahmood, Peter D. Craggs, Isobel L Harada, Rino A Bit, Natalie Wellaway, Armelle Le Gall, Robert J. Watson, Tony W Dean, Dominique Amans, Ian D. Wall, Kayleigh A J Stafford, Dave Lugo, Matthew J Lindon, Rishi R Shah, David Jonathan Hirst, Chris Patten, Darren L Poole, Jack A Brown, Philip G Humphreys, Robert P Davis, Christopher Roland Wellaway, Pamela J Thomas
Publikováno v:
Journal of Medicinal Chemistry. 63:714-746
The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators of the epigenome through their ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails. These interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb502737af78aed357d47636c87313d
https://doi.org/10.1021/acs.jmedchem.9b01670
https://doi.org/10.1021/acs.jmedchem.9b01670
Autor:
James M. Woolven, William J. Kerr, Chun-wa Chung, Bhumika Karamshi, Beata S. Wyspiańska, John Evans, Emmanuel Hubert Demont, Laurie Gordon, Matthew J Lindon, Peter E. Soden, Rob Willis, Leanne Cutler, Darren J. Mitchell, Christopher Roland Wellaway, Antonia J. Lewis, Robert J. Watson, Paul Bamborough, Simon Taylor, Inmaculada Rioja, Sharon G. Bernard, Rab K. Prinjha, Peter D. Craggs
The bromodomain and extraterminal domain (BET) family of epigenetic regulators comprises four proteins (BRD2, BRD3, BRD4, BRDT), each containing tandem bromodomains. To date, small molecule inhibitors of these proteins typically bind all eight bromod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2071ff9f599969eeda5e1e32f456446
https://strathprints.strath.ac.uk/73542/1/Wellaway_etal_JMC_2020_Structure_based_design_of_a_bromodomain_and_extraterminal_domain_BET_inhibitor.pdf
https://strathprints.strath.ac.uk/73542/1/Wellaway_etal_JMC_2020_Structure_based_design_of_a_bromodomain_and_extraterminal_domain_BET_inhibitor.pdf
Autor:
Peter Ernest Soden, Emma J. Roberts, Danette L. Daniels, Chun-wa Chung, Stephen John Atkinson, Paul Bamborough, Anne Marie Michon, Johanna Vappiani, Andrea C. Haynes, Massimo Petretich, Marcus Bantscheff, Miriam M. Yeung, Matthew J Bell, Sarah-Jane Dawson, Paola Grandi, Dane Vassiliadis, Simon Taylor, James Gray, Omer Gilan, Kathy Knezevic, Marjeta Urh, Matthew J Lindon, Marian L. Burr, Rab K. Prinjha, Alex Preston, Inmaculada Rioja, Mark A. Dawson, Gerard Drewes, Thilo Werner, Christopher Roland Wellaway, Emmanuel Hubert Demont, Anna K. Bassil, Nicola Harker, Thomas Gobbetti, Enid Y.N. Lam, David F. Tough, Vinod Kumar
Publikováno v:
Science
Bromodomain inhibitors revisited Bromodomain and extraterminal domain (BET) proteins contribute to the pathogenesis of cancer and immune diseases through their effects on transcriptional regulation. BET proteins contain two nearly identical bromodoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f230e3011891f1a84ffe803aee2fab
https://europepmc.org/articles/PMC7610820/
https://europepmc.org/articles/PMC7610820/
Autor:
Andrew G. Jamieson, Andrew Sutherland, David Nobis, Steven W. Magennis, Eilidh Malcolm, Astrid Knuhtsen, Alexander H. Harkiss, Jonathan D. Bell, Christopher Roland Wellaway
Publikováno v:
Chemical communications (Cambridge, England). 56(12)
The synthesis and photophysical properties of a new class of α-amino acid bearing a rigid pyrazoloquinazoline chromophore are described. Confromational constraint of the amino acid side-chains resulted in high emission quantum yields, while the demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31483680f0753a36015479cc8e0cc039
https://pubmed.ncbi.nlm.nih.gov/31956866
https://pubmed.ncbi.nlm.nih.gov/31956866
Autor:
Sean P. Bew, Richard J. D. Hatley, Christopher J. Richards, Michael J. O’ Sullivan, Christopher Roland Wellaway
Publikováno v:
Tetrahedron. 100:132455
Reaction of methyl-2-(2-formylphenyl)acetate with primary amines in a reductive amination/cyclisation process resulted in N-substituted 1,4-dihydro-3(2H)-isoquinolinones. With H 2NCH 2R sodium borohyride is a suitable reductant (11 examples), but H 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424a64aab0df318deff4c91d2b59d430
https://doi.org/10.1016/j.tet.2021.132455
https://doi.org/10.1016/j.tet.2021.132455
Autor:
Aoife Ward, Dean Tyler, Sarah-Jane Dawson, Edwin D. Hawkins, Paola Grandi, Dave Lugo, Johanna Vappiani, Richard Gregory, Anna Rutkowska, Tatiana Cañeque, Susan Jackson, Cesar Ramirez Molina, Antje Hienzsch, Anne J. Wagner, Rab K. Prinjha, Mark A. Dawson, Thilo Werner, Neil Stuart Garton, Charles C. Bell, Christopher Roland Wellaway, Omer Gilan, Colin M. House, Margarida Figueiredo, Yih-Chih Chan, Gerard Drewes, Raphaël Rodriguez, Laura MacPherson, Sabine Stolzenburg, Enid Y.N. Lam
Publikováno v:
Science
Are better drugs just a click away? Drugs that show promise in preclinical models often fail in the clinic, in part because of limited information on drug localization within cells and across tissues. In a proof-of-concept study, Tyler et al. applied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5123a076431a75df738f6e7c864d28ab
https://doi.org/10.1126/science.aal2066
https://doi.org/10.1126/science.aal2066
Autor:
Alexander H. Harkiss, Andrew Sutherland, Ned Buijs, Jonathan D. Bell, Timaeus E. F. Morgan, Christopher Roland Wellaway
Publikováno v:
The Journal of organic chemistry. 84(16)
The synthesis of a new class of benzotriazole-derived α-amino acid is described using a highly efficient nucleophilic aromatic substitution of ortho-fluoronitrobenzenes with l-3-aminoalanine and a ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4fd5d9d408004649653db879b61ae2
https://pubmed.ncbi.nlm.nih.gov/31340638
https://pubmed.ncbi.nlm.nih.gov/31340638
Publikováno v:
Organicbiomolecular chemistry. 16(35)
An acid-mediated 6-endo-trig cyclisation of amine-substituted enones has been developed for the stereoselective synthesis of trans-6-alkyl-2-methyl-4-oxopiperidines. Performed under conditions that prevent removal of the Boc-protecting group or aceta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96a70b1eb2e127e0d1d57469c806b4c
https://pubmed.ncbi.nlm.nih.gov/30011344
https://pubmed.ncbi.nlm.nih.gov/30011344
Autor:
Andrew D. Roberts, Bhumika Karamshi, Angela Bridges, Hawa Diallo, Chun-wa Chung, Kelly Locke, Peter D. Craggs, Darren Jason Mitchell, Paul Bamborough, Amanda Emmons, Christopher Roland Wellaway, Emma J. Jones, David P. Dixon, Robert J. Watson, Nathalie Barrett, Emmanuel Hubert Demont, Clement Douault, Robert J. Sheppard, Rab K. Prinjha, Rebecca C. Furze, Anne-Marie Michon, Paola Grandi, Bernadette Mouzon
Publikováno v:
Journal of medicinal chemistry. 58(14)
Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the dependenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb3845b766f600c6cb136aa5e1eb88a
https://pubmed.ncbi.nlm.nih.gov/26155854
https://pubmed.ncbi.nlm.nih.gov/26155854