Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Christopher R. Shaler"'
Autor:
Christopher R. Shaler, Alexandra A. Parco, Wael Elhenawy, Jasmeen Dourka, Jennifer Jury, Elena F. Verdu, Brian K. Coombes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Altered gut microbiome and exacerbation of symptoms at times of psychological stress are feature characteristics of Crohn’s disease. Here authors show in a mouse model that psychological stress impairs IL-22-dependent protective immunity of the ile
Externí odkaz:
https://doaj.org/article/062f55d29a194e71a96d5f94c1c3d3f7
Autor:
Peter A. Szabo, Ram V. Anantha, Christopher R. Shaler, John K. McCormick, S.M. Mansour eHaeryfar
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Dysregulated immune responses to infection such as those encountered in sepsis can be catastrophic. Sepsis is typically triggered by an overwhelming systemic response to an infectious agent(s) and is associated with high morbidity and mortality even
Externí odkaz:
https://doaj.org/article/5cf26b73b2be411ea78a2f621ad88ffd
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
Mycobacterium tuberculosis (M.tb), the causative bacterium of pulmonary tuberculosis (TB), is a serious global health concern. Central to M.tb effective immune avoidance is its ability to modulate the early innate inflammatory response and prevent th
Externí odkaz:
https://doaj.org/article/dccf3cd2ec4e4042a70288d58476fc23
Autor:
Francesco Marincola, Melissa Myint, Monika Pradhan, Jeffrey Lauer, Christopher R Shaler, Sabin Dhakal, Yeon Sook Choi, Pathricia V Tilstam, Aesha Upadhyay, Daniela Maiz, Jeremy Fung, Jingzang Tao Miu, Carlos Sanmarco, Erik Hett, Volker Herrmann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/cbbe2242cc474d1eb845db78083fcb98
Autor:
Christopher R Shaler, Joshua Choi, Patrick T Rudak, Arash Memarnejadian, Peter A Szabo, Mauro E Tun-Abraham, Jamie Rossjohn, Alexandra J Corbett, James McCluskey, John K McCormick, Olivier Lantz, Roberto Hernandez-Alejandro, S M Mansour Haeryfar
Publikováno v:
PLoS Biology, Vol 15, Iss 6, p e2001930 (2017)
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically
Externí odkaz:
https://doaj.org/article/4b24ea4518434fc0a5371e496f1d85b0
Autor:
Varun C Anipindi, Puja Bagri, Kristy Roth, Sara E Dizzell, Philip V Nguyen, Christopher R Shaler, Derek K Chu, Rodrigo Jiménez-Saiz, Hong Liang, Stephanie L Swift, Aisha Nazli, Jessica K Kafka, Jonathan Bramson, Zhou Xing, Manel Jordana, Yonghong Wan, Denis P Snider, Martin R Stampfli, Charu Kaushic
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005706 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005589.].
Externí odkaz:
https://doaj.org/article/eebc962c75124bf780feacd536885147
Autor:
Varun C Anipindi, Puja Bagri, Kristy Roth, Sara E Dizzell, Philip V Nguyen, Christopher R Shaler, Derek K Chu, Rodrigo Jiménez-Saiz, Hong Liang, Stephanie Swift, Aisha Nazli, Jessica K Kafka, Jonathan Bramson, Zhou Xing, Manel Jordana, Yonghong Wan, Denis P Snider, Martin R Stampfli, Charu Kaushic
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005589 (2016)
Clinical and experimental studies have shown that estradiol (E2) confers protection against HIV and other sexually transmitted infections. Here, we investigated the underlying mechanism. Better protection in E2-treated mice, immunized against genital
Externí odkaz:
https://doaj.org/article/51cd4b05244741f380caef5b4efa94b7
Autor:
Wael Elhenawy, Elena F. Verdu, Jasmeen Dourka, Christopher R. Shaler, Alexandra A. Parco, Brian K. Coombes, Jennifer Jury
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Crohn’s disease is an inflammatory disease of the gastrointestinal tract characterized by an aberrant response to microbial and environmental triggers. This includes an altered microbiome dominated by Enterobacteriaceae and in particular adherent-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613fcdf6b2afae8cb11ba0ee722ab458
https://doi.org/10.1038/s41467-021-26992-4
https://doi.org/10.1038/s41467-021-26992-4
Autor:
Trevor C. Lau, Aline Fiebig-Comyn, Christopher R. Shaler, Jonathan D. Schertzer, Brian K. Coombes, Joseph B. McPhee
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 321(3)
It is commonly thought that obesity or a high-fat diet alters pathogenic bacteria and promotes inflammatory gut diseases. We found that lower dietary fiber is a key factor that expands a gut pathobiont linked to Crohn’s disease, independent of obes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a227be233901d2554ab126e084e560f
https://pubmed.ncbi.nlm.nih.gov/34280051
https://pubmed.ncbi.nlm.nih.gov/34280051
Publikováno v:
Journal of Molecular Biology. 431:2970-2981
Escherichia coli is one of the most genetically and phenotypically diverse species of bacteria. This remarkable diversity produces a plethora of clinical outcomes following infection and has informed much of what we currently know about host-pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663b071906b40c07938cedc4d7a3babb
https://doi.org/10.1016/j.jmb.2019.04.023
https://doi.org/10.1016/j.jmb.2019.04.023