Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Christopher R. Pierson"'
Autor:
Jesse J. Westfall, Wesley N. Schwind, Sahibjot Sran, Jason B. Navarro, Jeffrey Leonard, Jonathan A. Pindrik, Christopher R. Pierson, Daniel R. Boué, Daniel C. Koboldt, Adam P. Ostendorf, Richard K. Wilson, Elaine R. Mardis, Katherine E. Miller, Tracy A. Bedrosian
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Rasmussen encephalitis (RE) is a rare childhood neurological disease characterized by progressive unilateral loss of function, hemispheric atrophy and drug-resistant epilepsy. Affected brain tissue shows signs of infiltrating cytotoxic T-cel
Externí odkaz:
https://doaj.org/article/7172266047244c74a00d43d4b08784a7
Autor:
Norman L. Lehman, Nathalie Spassky, Müge Sak, Amy Webb, Cory T. Zumbar, Aisulu Usubalieva, Khaled J. Alkhateeb, Joseph P. McElroy, Kirsteen H. Maclean, Paolo Fadda, Tom Liu, Vineela Gangalapudi, Jamie Carver, Zied Abdullaev, Cynthia Timmers, John R. Parker, Christopher R. Pierson, Bret C. Mobley, Murat Gokden, Eyas M. Hattab, Timothy Parrett, Ralph X. Cooke, Trang D. Lehman, Stefan Costinean, Anil Parwani, Brian J. Williams, Randy L. Jensen, Kenneth Aldape, Akshitkumar M. Mistry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Astroblastoma (AB) is an uncommon brain tumour and its origin remains unknown. Here, the authors perform integrative molecular analysis of 35 AB-like tumours and provide evidence that these arise in the context of epigenetic and genetic changes in ne
Externí odkaz:
https://doaj.org/article/266af82a90ee4ef5acf49b85f9abf738
Autor:
Margaret Shatara, Kathleen M. Schieffer, Darren Klawinski, Diana L. Thomas, Christopher R. Pierson, Eric A. Sribnick, Jeremy Jones, Diana P. Rodriguez, Carol Deeg, Elizabeth Hamelberg, Stephanie LaHaye, Katherine E. Miller, James Fitch, Benjamin Kelly, Kristen Leraas, Ruthann Pfau, Peter White, Vincent Magrini, Richard K. Wilson, Elaine R. Mardis, Mohamed S. Abdelbaki, Jonathan L. Finlay, Daniel R. Boué, Catherine E. Cottrell, David R. Ghasemi, Kristian W. Pajtler, Diana S. Osorio
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-10 (2021)
Abstract Primary spinal cord tumors contribute to ≤ 10% of central nervous system tumors in individuals of pediatric or adolescent age. Among intramedullary tumors, spinal ependymomas make up ~ 30% of this rare tumor population. A twelve-year-old m
Externí odkaz:
https://doaj.org/article/caf4e2efb62e4d51aaa27696a5bedd05
Autor:
Katherine E. Miller, Gregory Wheeler, Stephanie LaHaye, Kathleen M. Schieffer, Sydney Cearlock, Lakshmi Prakruthi Rao Venkata, Alejandro Otero Bravo, Olivia E. Grischow, Benjamin J. Kelly, Peter White, Christopher R. Pierson, Daniel R. Boué, Selene C. Koo, Darren Klawinski, Mark A. Ranalli, Ammar Shaikhouni, Ralph Salloum, Margaret Shatara, Jeffrey R. Leonard, Richard K. Wilson, Catherine E. Cottrell, Elaine R. Mardis, Daniel C. Koboldt
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Rhabdoid tumors (RTs) of the brain (atypical teratoid/rhabdoid tumor; AT/RT) and extracranial sites (most often the kidney; RTK) are malignant tumors predominantly occurring in children, frequently those with SMARCB1 germline alterations. Here we pre
Externí odkaz:
https://doaj.org/article/6f21c87851ce462a9ed11e94397b6312
Autor:
Kathleen M. Schieffer, Alexander Z. Feldman, Esko A. Kautto, Sean McGrath, Anthony R. Miller, Maria Elena Hernandez-Gonzalez, Stephanie LaHaye, Katherine E. Miller, Daniel C. Koboldt, Patrick Brennan, Benjamin Kelly, Amy Wetzel, Vibhuti Agarwal, Margaret Shatara, Suzanne Conley, Diana P. Rodriguez, Rolla Abu-Arja, Ala Shaikhkhalil, Matija Snuderl, Brent A. Orr, Jonathan L. Finlay, Diana S. Osorio, Annie I. Drapeau, Jeffrey R. Leonard, Christopher R. Pierson, Peter White, Vincent Magrini, Elaine R. Mardis, Richard K. Wilson, Catherine E. Cottrell, Daniel R. Boué
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021)
Abstract Retinoblastoma is a childhood cancer of the retina involving germline or somatic alterations of the RB Transcriptional Corepressor 1 gene, RB1. Rare cases of sellar-suprasellar region retinoblastoma without evidence of ocular or pineal tumor
Externí odkaz:
https://doaj.org/article/85b8e7d1df914feb8bd8c86c7a9bff75
Autor:
Xiang Chen, Li Pan, Jia Wei, Ruijie Zhang, Xiaozhi Yang, Jinhua Song, Ren-Yuan Bai, Shengling Fu, Christopher R. Pierson, Jonathan L. Finlay, Chenglong Li, Jiayuh Lin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor and an oncogene product, which plays a pivotal role in tumor progression. Therefore, targeting persistent STAT3 signaling directly is an attractive anticanc
Externí odkaz:
https://doaj.org/article/bfd18968512a4e99a84e2b1b85bb2f69
Autor:
Norman L. Lehman, Nathalie Spassky, Müge Sak, Amy Webb, Cory T. Zumbar, Aisulu Usubalieva, Khaled J. Alkhateeb, Joseph P. McElroy, Kirsteen H. Maclean, Paolo Fadda, Tom Liu, Vineela Gangalapudi, Jamie Carver, Zied Abdullaev, Cynthia Timmers, John R. Parker, Christopher R. Pierson, Bret C. Mobley, Murat Gokden, Eyas M. Hattab, Timothy Parrett, Ralph X. Cooke, Trang D. Lehman, Stefan Costinean, Anil Parwani, Brian J. Williams, Randy L. Jensen, Kenneth Aldape, Akshitkumar M. Mistry
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/1f6fc156e6604e9bbe9bcaf99d265dea
Autor:
Naresh C. Bal, Subash C. Gupta, Meghna Pant, Danesh H. Sopariwala, Geoffrey Gonzalez-Escobedo, Joanne Turner, John S. Gunn, Christopher R. Pierson, Scott Q. Harper, Jill A. Rafael-Fortney, Muthu Periasamy
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Sarcolipin (SLN) is a regulator of sarco/endo plasmic reticulum Ca2+-ATPase (SERCA) pump and has been shown to be involved in muscle nonshivering thermogenesis (NST) and energy metabolism. Interestingly, SLN expression is significantly upregulated bo
Externí odkaz:
https://doaj.org/article/9fa533c381984d0a99075e9109bdb9d7
Autor:
Jessica Blackburn, Valeria F. Chapur, Julie A. Stephens, Jing Zhao, Anne Shepler, Christopher R. Pierson, José Javier Otero
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Sudden infant death syndrome (SIDS) is one of the leading causes of infant mortality in the United States (US). The extent to which SIDS manifests with an underlying neuropathological mechanism is highly controversial. SIDS correlates wit
Externí odkaz:
https://doaj.org/article/82b29b277ff140c981e9fe7c023c22b0
Autor:
Adam W. Studebaker, Brian J. Hutzen, Christopher R. Pierson, Kellie B. Haworth, Timothy P. Cripe, Eric M. Jackson, Jeffrey R. Leonard
Publikováno v:
Molecular Therapy: Oncolytics, Vol 6, Iss C, Pp 22-30 (2017)
Pediatric brain tumors including medulloblastoma and atypical teratoid/rhabdoid tumor are associated with significant mortality and treatment-associated morbidity. While medulloblastoma tumors within molecular subgroups 3 and 4 have a propensity to m
Externí odkaz:
https://doaj.org/article/43d0e8de0bde4d99ad7c97b2a028b0cf