Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Christopher R. Logg"'
Autor:
Chien-Kuo Tai, Noriyuki Kasahara, Mark Tangney, Christopher R. Logg, Sara Collins, Akihito Inagaki, Peter F. Searle
Publikováno v:
Neuro Oncol
Early-phase clinical trials of Toca 511, a retroviral replicating vector (RRV) expressing an optimized form of yeast cytosine deaminase for prodrug activator gene therapy, showed highly promising evidence of therapeutic benefit and increased survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696a7227afc5f0e7defd36957e6d53d
https://europepmc.org/articles/PMC7651312/
https://europepmc.org/articles/PMC7651312/
Autor:
Christopher R. Logg, Joan M. Robbins, Douglas J. Jolly, Carlos E. Ibanez, Harry E. Gruber, Kathrina Cunanan, Cynthia Burrascano, Yanzheng Liu, Noriyuki Kasahara, Amy H. Lin
Publikováno v:
Human Gene Therapy Methods. 27:59-70
We have developed retroviral replicating vectors (RRV) derived from Moloney murine gammaretrovirus with an amphotropic envelope and an encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES)-transgene cassette downstream of the env gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8c7d19d58bda4341f4a63aacd1d5df
https://doi.org/10.1089/hgtb.2015.131
https://doi.org/10.1089/hgtb.2015.131
Autor:
Taylor Buckley, Kei Hiraoka, Ryan Burnett, Akihito Inagaki, Christopher R. Logg, Cindy Burrascano, Douglas J. Jolly, Carlos E. Ibanez, Daniel L. Lohse, Karin Kristina Amundson, Dawn Jolson, Oscar Diago, Noriyuki Kasahara, Amy Lin, Omar D. Perez, Harry E. Gruber
Publikováno v:
Molecular Therapy. 20:1689-1698
Retroviral replicating vectors (RRVs) are a nonlytic alternative to oncolytic replicating viruses as anticancer agents, being selective both for dividing cells and for cells that have defects in innate immunity and interferon responsiveness. Tumor ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f44f7b56c4cb27af1bcdd855b5f22e
https://doi.org/10.1038/mt.2012.83
https://doi.org/10.1038/mt.2012.83
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 40, iss 15
Nucleic acids research, vol 40, iss 15
A vast amount of research on the regulation of gene expression has relied on plasmid reporter assays. In this study, we show that plasmids widely used for this purpose constitutively produce substantial amounts of RNA from a TATA-containing cryptic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2225fdd006703248d877dfa9088c24ca
https://doi.org/10.1093/nar/gks451
https://doi.org/10.1093/nar/gks451
Publikováno v:
The Journal of Gene Medicine. 12:528-537
Background Bioluminescence imaging (BLI) permits the non-invasive quantification and localization of transduction and expression by gene transfer vectors. The tendency of tissue to attenuate light in the optical region, however, limits the sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc162b26bc7f402073155f01da8ee49
https://doi.org/10.1002/jgm.1463
https://doi.org/10.1002/jgm.1463
Autor:
Carlos Cordon-Cardo, Makato Ohori, Choichiro Ozu, Christopher R. Logg, Silvia Menendez, Bernard H. Bochner, Eiji Kikuchi, Noriyuki Kasahara
Publikováno v:
Clinical Cancer Research. 13:4511-4518
Purpose: In an attempt to improve viral delivery of potentially therapeutic genes via an intravesical route, we have recently developed murine leukemia virus-based replication-competent retrovirus (RCR) vectors. Experimental Design: We evaluated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd57c7c8e45b365b6c85c098e76d9ba
https://doi.org/10.1158/1078-0432.ccr-07-0151
https://doi.org/10.1158/1078-0432.ccr-07-0151
Autor:
G.G. Gomez, C.A. Kruse, Renata Stripecke, Jill Nagashima, Nathan A. Lemp, James C. Cicciarelli, Robert Mendez, Christopher R. Logg, Noriyuki Kasahara, Kazunori Haga, Emmanuelle Faure-Kumar
Publikováno v:
Transplantation Proceedings. 38:3184-3188
Transplantation of many tissues requires histocompatibility matching of human leukocyte antigens (HLA) to prevent graft rejection, to reduce the level of immunosuppression needed to maintain graft survival, and to minimize the risk of graft-versus-ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5a8c2302f167d1c4674d0a62e2e30b
https://doi.org/10.1016/j.transproceed.2006.10.158
https://doi.org/10.1016/j.transproceed.2006.10.158
Publikováno v:
Clin Cancer Res
Purpose: Replication-competent retrovirus (RCR) vectors have been shown to achieve highly efficient and tumor-restricted replicative spread and gene transfer in vivo after direct intratumoral injection in a variety of primary cancer models. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9057cce1e995da2d0e1c93832dabd0
https://doi.org/10.1158/1078-0432.ccr-06-1452
https://doi.org/10.1158/1078-0432.ccr-06-1452
Publikováno v:
Current Gene Therapy. 5:655-667
As cancer gene therapy employing replication-defective vectors has met with limited clinical success, there is renewed interest in using replication-competent viruses for oncolytic virotherapy. In preclinical and clinical studies, various attenuated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0292f3048f37b0979c3ec09018f91cc2
https://doi.org/10.2174/156652305774964659
https://doi.org/10.2174/156652305774964659
Autor:
Jinha M. Park, Chien Kuo Tai, Noriyuki Kasahara, Christopher R. Logg, W. French Anderson, Michael F. Press
Publikováno v:
Human Gene Therapy. 14:789-802
Replication-competent murine leukemia virus (MLV) vectors can be engineered to achieve high efficiency gene transfer to solid tumors in vivo and tumor-restricted replication, however their safety can be further enhanced by redirecting tropism of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1368617f4f734f16e77e0726f250fe98
https://doi.org/10.1089/104303403765255174
https://doi.org/10.1089/104303403765255174