Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Christopher R. Gibson"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Abstract This short report describes the measurement of total liver blood flow in commonly used laboratory rats using the relatively non‐invasive approach of ultrasound imaging. A total of 29 rats (n = 26 Wistar‐Han, n = 3 Sprague–Dawley) were
Externí odkaz:
https://doaj.org/article/99f9c6df3f204338ada0d02e4d6796ff
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2342
There are many factors which are known to cause variability in human in vitro enzyme kinetic data. Factors such as the source of enzyme and how it was prepared, the genetics and background of the donor, how the in vitro studies are designed, and how
Autor:
Christopher R. Gibson, Hiroyuki Yoshitsugu, Georgy Hartmann, Tamara D. Cabalu, Yuki Matsumoto, Naoto Uemura, Punam Sandhu, Takashi Iwasa
Publikováno v:
Clinical Pharmacology and Therapeutics
Pharmacokinetics (PKs) in Japanese healthy subjects were simulated for nine compounds using physiologically based PK (PBPK) models parameterized with physicochemical properties, preclinical absorption, distribution, metabolism, and excretion (ADME) d
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
This short report describes the measurement of total liver blood flow in commonly used laboratory rats using the relatively non‐invasive approach of ultrasound imaging. A total of 29 rats (n = 26 Wistar‐Han, n = 3 Sprague–Dawley) were imaged an
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615539
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c000c47e684a75f36b24acef5be0e146
https://doi.org/10.1007/978-1-0716-1554-6_16
https://doi.org/10.1007/978-1-0716-1554-6_16
Autor:
Joshua D. Vardigan, Christopher R. Gibson, Darrell A. Henze, Andrea K. Houghton, Marie A. Holahan, Fuqiang Zhao, Parul S. Pall, Richard L. Kraus, Yuxing Li, Jeanine E. Ballard, Christopher S. Burgey
Publikováno v:
Pharmaceutical Research
Purpose This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic (PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor drug discovery effort to address strategic questions regarding in vitro to
Autor:
Christine Brandquist, S. Aubrey Stoch, Rose Witter, Cynthia Dempsey, Christopher R. Gibson, Filippos Kesisoglou, Stefan Zajic, Marc L. Reitman, Jeanine E. Ballard, Daria Stypinski, Kelem Kassahun, Anish Mehta
Publikováno v:
The Journal of Clinical Pharmacology. 57:110-117
This open-label 2-period study assessed the effect of multiple-dose administration of rifampin, a strong cytochrome P450 3A (CYP3A) and P-glycoprotein inducer, on the pharmacokinetics of odanacatib, a cathepsin K inhibitor. In period 1, 12 healthy ma
Autor:
Bennett Ma, Sean T. Smith, Anne Chain, Christopher R. Gibson, Sauzanne Khalilieh, Thomas Bateman, Ying Li, Georgy Hartmann, Mark Forman, Sandip Datta
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S87
Autor:
Eric M. Parker, Sandra A.G. Visser, Maria E. Trujillo, Mallika Lala, Matthew L. Rizk, Tjerk Bueters, Daniel Tatosian, Christopher R. Gibson, Prajakti A. Kothare, Pavan Vaddady
Publikováno v:
Early Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24981f06c4f8ea76f82aa36ec113d0cd
https://doi.org/10.1002/9783527801756.ch17
https://doi.org/10.1002/9783527801756.ch17
Autor:
Majid Vakilynejad, Arijit Chakravarty, Tonika Bohnert, Anu Shilpa Krishnatry, Jerome T. Mettetal, Tristan S. Maurer, Christopher R. Gibson, Daniel R. Mudra, Edgar Schuck, Yaming Su, Marjoleen J.M.A Nijsen, Tycho Heimbach, Shining Wang, Virna J A Schuck, Cheng-Pang Hsu, Harvey Wong, Patrick Trapa, Joseph Raybon, Patricia Schroeder, Satyendra Suryawanshi, Jing Lin, Bianca M. Liederer, Valeriu Damian-Iordache, Alice Tsai
Publikováno v:
The AAPS Journal. 17:462-473
The application of modeling and simulation techniques is increasingly common in preclinical stages of the drug discovery and development process. A survey focusing on preclinical pharmacokinetic/pharmacodynamics (PK/PD) analysis was conducted across