Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Christopher R. Bethel"'
Autor:
Khalid M. Dousa, Eunjeong Shin, Sebastian G. Kurz, Mark Plummer, Mary Nantongo, Christopher R. Bethel, Magdalena A. Taracila, David C. Nguyen, Barry N. Kreiswith, Charles L. Daley, Kenneth E. Remy, Steven M. Holland, Robert A. Bonomo
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Mycobacterium abscessus (Mab) affects patients with immunosuppression or underlying structural lung diseases such as cystic fibrosis (CF). Additionally, Mab poses clinical challenges due to its resistance to multiple antibiotics. Herein, we
Externí odkaz:
https://doaj.org/article/fa9a808cd6454120a8ebb14d852179cd
Autor:
Jennifer M. Colquhoun, Marjan Farokhyfar, Alexander C. Anderson, Christopher R. Bethel, Robert A. Bonomo, Anthony J. Clarke, Philip N. Rather
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT The ADC (AmpC) β-lactamase is universally present in the Acinetobacter baumannii chromosome, suggesting it may have a yet-to-be-identified cellular function. Using peptidoglycan composition analysis, we show that overexpressing the ADC-7 β
Externí odkaz:
https://doaj.org/article/c09b7aa4fb2e419cbd3bbd5b7112233e
Autor:
Krisztina M. Papp-Wallace, Melissa D. Barnes, Magdalena A. Taracila, Christopher R. Bethel, Joseph D. Rutter, Elise T. Zeiser, Katherine Young, Robert A. Bonomo
Publikováno v:
Antibiotics, Vol 12, Iss 5, p 892 (2023)
Background: Ceftazidime-avibactam was approved by the FDA to treat infections caused by Enterobacterales carrying blaKPC-2. However, variants of KPC-2 with amino acid substitutions at position 179 have emerged and confer resistance to ceftazidime-avi
Externí odkaz:
https://doaj.org/article/606befb249374f02ba1162f285615328
Autor:
Philip Hinchliffe, Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher Arthur, Kate J. Heesom, Stuart Shapiro, Daniela M. Schlatzer, Krisztina M. Papp-Wallace, Robert A. Bonomo, James Spencer
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that di
Externí odkaz:
https://doaj.org/article/b7b931b90cef4f15b5875e2a595d88ff
Autor:
Khalid M. Dousa, David C. Nguyen, Sebastian G. Kurz, Magdalena A. Taracila, Christopher R. Bethel, William Schinabeck, Barry N. Kreiswirth, Sheldon T. Brown, W. Henry Boom, Richard S. Hotchkiss, Kenneth E. Remy, Frank J. Jacono, Charles L. Daley, Steven M. Holland, Alita A. Miller, Robert A. Bonomo
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Mycobacterium abscessus (Mab) infections are a growing menace to the health of many patients, especially those suffering from structural lung disease and cystic fibrosis. With multidrug resistance a common feature and a growing understanding
Externí odkaz:
https://doaj.org/article/89354fdd37e14eba94df814fcd3ea960
Autor:
Tatsuya Ishikawa, Nayuta Furukawa, Emilia Caselli, Fabio Prati, Magdalena A. Taracila, Christopher R. Bethel, Yoshikazu Ishii, Akiko Shimizu-Ibuka, Robert A. Bonomo
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The rise of multidrug resistant (MDR) Gram-negative bacteria has accelerated the development of novel inhibitors of class A and C β-lactamases. Presently, the search for novel compounds with new mechanisms of action is a clinical and scientific prio
Externí odkaz:
https://doaj.org/article/32eaf9b91e32478f8f3fd5a213b6b2f8
Autor:
Jennifer M. Colquhoun, Marjan Farokhyfar, Anna R. Hutcheson, Alexander Anderson, Christopher R. Bethel, Robert A. Bonomo, Anthony J. Clarke, Philip N. Rather
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT β-Lactamase expression is the major mechanism of resistance to penicillins, cephalosporins, and carbapenems in the multidrug-resistant (MDR) bacterium Acinetobacter baumannii. In fact, stable high-level expression of at least one β-lactama
Externí odkaz:
https://doaj.org/article/480fdfe5fbe64cbcafe5beec72f3166d
Autor:
Zishuo Cheng, Ben A. Shurina, Christopher R. Bethel, Pei W. Thomas, Steven H. Marshall, Caitlyn A. Thomas, Kundi Yang, Robert L. Kimble, Jonathan S. Montgomery, Matthew G. Orischak, Callie M. Miller, Jordan L. Tennenbaum, Jay C. Nix, David L. Tierney, Walter Fast, Robert A. Bonomo, Richard C. Page, Michael W. Crowder
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT To understand the evolution of Verona integron-encoded metallo-β-lactamase (VIM) genes (blaVIM) and their clinical impact, microbiological, biochemical, and structural studies were conducted. Forty-five clinically derived VIM variants engin
Externí odkaz:
https://doaj.org/article/456a2252f5b9467492680466c100f2cc
Autor:
Melissa D. Barnes, Vijay Kumar, Christopher R. Bethel, Samir H. Moussa, John O’Donnell, Joseph D. Rutter, Caryn E. Good, Kristine M. Hujer, Andrea M. Hujer, Steve H. Marshall, Barry N. Kreiswirth, Sandra S. Richter, Philip N. Rather, Michael R. Jacobs, Krisztina M. Papp-Wallace, Focco van den Akker, Robert A. Bonomo
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillina
Externí odkaz:
https://doaj.org/article/e9fdc0602a7742b6a7a1c6dfc92d0ab3
Autor:
Melissa D. Barnes, Magdalena A. Taracila, Joseph D. Rutter, Christopher R. Bethel, Ioannis Galdadas, Andrea M. Hujer, Emilia Caselli, Fabio Prati, John P. Dekker, Krisztina M. Papp-Wallace, Shozeb Haider, Robert A. Bonomo
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam an
Externí odkaz:
https://doaj.org/article/edb8dbd7a6454ff080c0150b5085a0a8