Restricting microbial exposure in early life negates the immune benefits associated with gut colonization in environments of high microbial diversity.

Autor: Imke E Mulder, Bettina Schmidt, Marie Lewis, Margaret Delday, Christopher R Stokes, Mick Bailey, Rustam I Aminov, Bhupinder P Gill, John R Pluske, Claus-Dieter Mayer, Denise Kelly

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28279 (2011)

BackgroundAcquisition of the intestinal microbiota in early life corresponds with the development of the mucosal immune system. Recent work on caesarean-delivered infants revealed that early microbial composition is influenced by birthing method and

Externí odkaz: https://doaj.org/article/55aaeb5944684f6f986190b6037c9a35

Development of Immune Cells in the Intestinal Mucosa Can Be Affected by Intensive and Extensive Farm Environments, and Antibiotic Use

Autor: Zoe Christoforidou, Rachel Burt, Imke Mulder, Bhupinder P. Gill, John Pluske, Denise Kelly, Christopher R. Stokes, Michael Bailey, Marie C. Lewis

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Epidemiological studies have demonstrated that exposure to farm environments during childhood can be linked to reductions in the incidence of immune disorders, but generating an appropriate model is difficult. 108 half-sibling piglets were born on ei

Externí odkaz: https://doaj.org/article/0031b23ae36d462da47f60149e7860a6

The dark side of technological advances in analysis of microbial ecosystems

Autor: Christopher R. Stokes, Hauke Smidt, Mick Bailey, Ore Francis, Amy Thomas

Publikováno v: Journal of Animal Science and Biotechnology 10 (2019) 1
Journal of Animal Science and Biotechnology
Journal of Animal Science and Biotechnology, Vol 10, Iss 1, Pp 1-11 (2019)
Bailey, M, Thomas, A, Francis, O, Stokes, C & Smidt, H 2019, ' The dark side of technological advances in analysis of microbial ecosystems ', Journal of Animal Science and Biotechnology, vol. 10, no. 1, 49 . https://doi.org/10.1186/s40104-019-0357-2
Journal of Animal Science and Biotechnology, 10(1)

Recent technological advances mean that samples from animal experiments may be analysed more cheaply, more easily and with a much greater return of data than previously. Research groups are frequently faced with a choice of continuing to use establis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c8fcf4761a4f5c01d284ba941f3eb3
https://research.wur.nl/en/publications/the-dark-side-of-technological-advances-in-analysis-of-microbial-

MEASUREMENT OF IL-12 (P40, P35), IL-23P19 AND IFN-MRNA IN DUODENAL BIOPSIES OF CATS WITH IBD AND HEALTHY CONTROLS USING QUANTITATIVE REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION (QRT-PCR)

Autor: V. Biourge, Timothy J Gruffydd-Jones, N. E. Waly, Christopher R. Stokes, Michael Bailey, Iain R. Peters, Michael J Day

Publikováno v: Mansoura Veterinary Medical Journal. 17:25-33

Dietary hypersensitivity and inflammatory bowel disease (IBD) are important causes of chronic vomiting and diarrhoea in cats. In this study, the expression of genes encoding Il12p35 and p40, IL-23p19 and IFN- was studied in duodenal biopsies taken fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::432980a57da35aad16f1f2cebd244b44
https://doi.org/10.21608/mvmj.2016.129719

Measurement of IL‐12 (p40, p35), IL‐23p19, and IFN‐γ mRNA in Duodenal Biopsies of Cats with Inflammatory Enteropathy

Autor: Timothy J Gruffydd-Jones, Iain R. Peters, Mick Bailey, N. E. Waly, Christopher R. Stokes, Michael J. Day

Publikováno v: Journal of Veterinary Internal Medicine

Background Dietary hypersensitivity and inflammatory bowel disease (IBD) are important causes of chronic vomiting and diarrhea in cats. IL-23 has been recently found to be a key factor in the immunopathogenesis of IBD in humans but the involvement in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec78601cf35ddd9096e1c864b89938d
http://europepmc.org/articles/PMC4895550