Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Christopher R Smith"'
Publikováno v:
ACS Omega, Vol 7, Iss 36, Pp 32062-32067 (2022)
Externí odkaz:
https://doaj.org/article/bb96fe09f2244a32baee7fd1a9a4530e
Autor:
Jill Hallin, Vickie Bowcut, Andrew Calinisan, David M. Briere, Lauren Hargis, Lars D. Engstrom, Jade Laguer, James Medwid, Darin Vanderpool, Ella Lifset, David Trinh, Natalie Hoffman, Xiaolun Wang, J. David Lawson, Robin J. Gunn, Christopher R. Smith, Nicole C. Thomas, Matthew Martinson, Alex Bergstrom, Francis Sullivan, Karyn Bouhana, Shannon Winski, Leo He, Julio Fernandez-Banet, Adam Pavlicek, Jacob R. Haling, Lisa Rahbaek, Matthew A. Marx, Peter Olson, James G. Christensen
Publikováno v:
Nature Medicine. 28:2171-2182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d677a7e099fb8459d3aaad7bbf29b468
https://doi.org/10.1038/s41591-022-02007-7
https://doi.org/10.1038/s41591-022-02007-7
Autor:
John M. Ketcham, Jacob Haling, Shilpi Khare, Vickie Bowcut, David M. Briere, Aaron C. Burns, Robin J. Gunn, Anthony Ivetac, Jon Kuehler, Svitlana Kulyk, Jade Laguer, J. David Lawson, Krystal Moya, Natalie Nguyen, Lisa Rahbaek, Barbara Saechao, Christopher R. Smith, Niranjan Sudhakar, Nicole C. Thomas, Laura Vegar, Darin Vanderpool, Xiaolun Wang, Larry Yan, Peter Olson, James G. Christensen, Matthew A. Marx
Publikováno v:
Journal of Medicinal Chemistry. 65:9678-9690
SOS1 is one of the major guanine nucleotide exchange factors that regulates the ability of KRAS to cycle through its "on" and "off" states. Disrupting the SOS1:KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe52dccfc91d77da8d18ff2be215969
https://doi.org/10.1021/acs.jmedchem.2c00741
https://doi.org/10.1021/acs.jmedchem.2c00741
Autor:
Christopher R. Smith, Ruth Aranda, Thomas P. Bobinski, David M. Briere, Aaron C. Burns, James G. Christensen, Jeffery Clarine, Lars D. Engstrom, Robin J. Gunn, Anthony Ivetac, Ronald Jean-Baptiste, John M. Ketcham, Masakazu Kobayashi, Jon Kuehler, Svitlana Kulyk, J. David Lawson, Krystal Moya, Peter Olson, Lisa Rahbaek, Nicole C. Thomas, Xiaolun Wang, Laura M. Waters, Matthew A. Marx
Publikováno v:
Journal of Medicinal Chemistry. 65:1749-1766
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6807ba018e034c41898a959b92d453dc
https://doi.org/10.1021/acs.jmedchem.1c01900
https://doi.org/10.1021/acs.jmedchem.1c01900
Autor:
Christopher R. Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G. Christensen, Robin J. Gunn, Anthony Ivetac, John M. Ketcham, Jon Kuehler, J. David Lawson, Nicole C. Thomas, Xiaolun Wang, Matthew A. Marx
Publikováno v:
RSC Medicinal Chemistry. 13:1549-1564
Herein we describe our approach to prioritize five fragment hits with the objective of answering three questions: could the binding potency be improved? Were the series chemically tractable? Could additional co-crystal structures be solved?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c927f9ba7684ab99a67e20faf2bf6f
https://doi.org/10.1039/d2md00163b
https://doi.org/10.1039/d2md00163b
Autor:
Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, Sean G. Buchanan
Supplementary Tables 1-3, Figures 1-4 from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b253da2b8af69b57f61a86d3221a13f9
https://doi.org/10.1158/1535-7163.22485138
https://doi.org/10.1158/1535-7163.22485138
Autor:
Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, Sean G. Buchanan
Supplementary Figure 1 from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee53a296e3d5b8a6d460e10e97860b5a
https://doi.org/10.1158/1535-7163.22485141.v1
https://doi.org/10.1158/1535-7163.22485141.v1
Autor:
Siegfried H. Reich, Stephen K. Burley, Spencer Emtage, Stephen R. Wasserman, Kevin Holme, Shane Atwell, Laura A. Pelletier, Lydia Smyth, Devon A. Thompson, Paul A. Sprengeler, Jeff M. Blaney, Tuan H. Do, Barbara C. Leon, Jason Adams, Isabelle A. Rooney, Marijane Russell, Kenneth D. Schwinn, J. Michael Sauder, Steve F. Gessert, Brandon E. Aubol, Marshall C. Peterman, Karen J. Froning, Jeremy D. Felce, Nanni H. Huser, Crystal M. Tang, Katti A. Jessen, Pierre-Yves Bounaud, Christopher R. Smith, Patrick S. Lee, Jorg Hendle, Sean G. Buchanan
The MET receptor tyrosine kinase has emerged as an important target for the development of novel cancer therapeutics. Activation of MET by mutation or gene amplification has been linked to kidney, gastric, and lung cancers. In other cancers, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265be7461b5631c4751aa9dac9de05d6
https://doi.org/10.1158/1535-7163.c.6531795.v1
https://doi.org/10.1158/1535-7163.c.6531795.v1
Autor:
Eva Y-H. P. Lee, Eric J. Stanbridge, Gabriel N. Hortobagyi, Gordon B. Mills, Yoon Kim, Shuanzeng Wei, Christopher R. Smith, Norazizah Shafee
Supplementary Table 1 from Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53–Mediated Mouse Mammary Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb1310431d4614403a4a5d6fe8da927
https://doi.org/10.1158/0008-5472.22375080.v1
https://doi.org/10.1158/0008-5472.22375080.v1
Autor:
Eva Y-H. P. Lee, Eric J. Stanbridge, Gabriel N. Hortobagyi, Gordon B. Mills, Yoon Kim, Shuanzeng Wei, Christopher R. Smith, Norazizah Shafee
Supplementary Figure 1 from Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53–Mediated Mouse Mammary Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea8d9e703b42b9489daca31bd3d42a3
https://doi.org/10.1158/0008-5472.22375083.v1
https://doi.org/10.1158/0008-5472.22375083.v1