Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Christopher R S Banerji"'
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-25 (2021)
Abstract Facioscapulohumeral muscular dystrophy (FSHD) is characterised by progressive skeletal muscle weakness and wasting. FSHD is linked to epigenetic derepression of the subtelomeric D4Z4 macrosatellite at chromosome 4q35. Epigenetic derepression
Externí odkaz:
https://doaj.org/article/c5e23813bf1949a6b6aa84f1244f2a2a
Autor:
Anthony Baptista, Alessandro Barp, Tapabrata Chakraborti, Chris Harbron, Ben D. MacArthur, Christopher R. S. Banerji
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Deep neural networks (DNNs) are powerful tools for approximating the distribution of complex data. It is known that data passing through a trained DNN classifier undergoes a series of geometric and topological simplifications. While some pro
Externí odkaz:
https://doaj.org/article/97e8c4f8b80743829e934cc3478f8c28
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 3, p e1004115 (2015)
The cancer stem cell hypothesis, that a small population of tumour cells are responsible for tumorigenesis and cancer progression, is becoming widely accepted and recent evidence has suggested a prognostic and predictive role for such cells. Intra-tu
Externí odkaz:
https://doaj.org/article/03e7241f72eb425f802273e3d8c8dd91
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Complex biological processes, such as cellular differentiation, require intricate rewiring of intra-cellular signalling networks. Previous characterisations revealed a raised network entropy underlies less differentiated and malignant cell s
Externí odkaz:
https://doaj.org/article/e0128e2e8e774f77a26841625fa62c15
Autor:
Thuy-Hang Nguyen, Lise Paprzycki, Alexandre Legrand, Anne-Emilie Declèves, Philipp Heher, Maelle Limpens, Alexandra Belayew, Christopher R. S. Banerji, Peter S. Zammit, Alexandra Tassin
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background Hypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlying the effects of hypoxia on human myoblast differentiation remain unclear. The hypoxic response pathway is o
Externí odkaz:
https://doaj.org/article/54f7e8b9df5a4c7f8986eef5f8194eb0
Autor:
Christopher R. S. Banerji, Philipp Heher, John Hogan, Natalie Katz, Husain Bin Haidar, Michael D. Keegan, Colin Cernik, Rabi Tawil, Ketan Patel, Peter S. Zammit, Jeffery M. Statland
Facioscapulohumeral muscular dystrophy (FSHD) is an incurable skeletal myopathy. In absence of therapy, lifestyle factors impacting disease progression are important for clinical management. Monozygotic twins with FSHD often exhibit dramatically diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6142fef6b8d2c2da9529c82b2413ba2c
https://doi.org/10.1101/2023.05.17.23290091
https://doi.org/10.1101/2023.05.17.23290091
Autor:
Christopher R. S. Banerji, Anna Greco, Leo A. B. Joosten, Baziel van Engelen, Peter S. Zammit
Facioscapulohumeral muscular dystrophy (FSHD) is incurable. DUX4 mis-expression is believed to underlie FSHD pathogenesis, alongside PAX7 target gene repression, yet clinical trials lack robust biomarkers of severity. FSHD entails fatty replacement o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79beca22d9611dbb82636272c1862b1a
https://doi.org/10.1101/2022.08.31.506017
https://doi.org/10.1101/2022.08.31.506017
Publikováno v:
Human Molecular Genetics
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant myopathy characterized by slowly progressive skeletal muscle weakness and wasting. While a regenerative response is often provoked in many muscular dystrophies, little is known ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36af5f04a73ce976089efc5f5fdd2b38
http://europepmc.org/articles/PMC7530526
http://europepmc.org/articles/PMC7530526
Autor:
Christopher R. S. Banerji
Publikováno v:
Human Molecular Genetics. 29:2124-2133
Facioscapulohumeral muscular dystrophy (FSHD) is a prevalent, inherited skeletal myopathy linked to hypomethylation of the D4Z4 macrosatellite at chromosome 4q35. This epigenetic de-repression permits expression of the transcription factor DUX4, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb49805c3390041bf82ffff207858937
https://doi.org/10.1093/hmg/ddaa079
https://doi.org/10.1093/hmg/ddaa079
Publikováno v:
Human Molecular Genetics
Facioscapulohumeral muscular dystrophy (FSHD) is a prevalent, incurable skeletal myopathy. The condition is linked to hypomethylation of the D4Z4 macrosatellite repeat at chromosome 4q35, leading to epigenetic derepression of the transcription factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408bcbadc837fa097cde6d38f1cdf43b
https://doi.org/10.1093/hmg/ddz043
https://doi.org/10.1093/hmg/ddz043