Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christopher R Curtin"'
Publikováno v:
JMIR Research Protocols
Background: The variety of alarms from all types of medical devices has increased from 6 to 40 in the last three decades, with today’s most critically ill patients experiencing as many as 45 alarms per hour. Alarm fatigue has been identified as a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788e2fbd5dc98f0f11465297a1a9676f
http://europepmc.org/articles/PMC6024101
http://europepmc.org/articles/PMC6024101
BACKGROUND The variety of alarms from all types of medical devices has increased from 6 to 40 in the last three decades, with today’s most critically ill patients experiencing as many as 45 alarms per hour. Alarm fatigue has been identified as a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bc2374e18eb1a635248ce3fd3db7552
https://doi.org/10.2196/preprints.10446
https://doi.org/10.2196/preprints.10446
Autor:
Joseph Murphy, Christopher R. Curtin, Shean-Sheng Wang, David Polidori, Ewa Wajs, Damayanthi Devineni, Hans Stieltjes
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 53:438-446
Aims Assess the steady-state pharmacokinetics, pharmacodynamics and safety of once-daily (q.d.) versus twice-daily (b.i.d.) dosing with canagliflozin at the same total daily doses of 100 and 300 mg in healthy participants. Methods 34 participants (17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf0fe4bfb4dd63df0fb2571d864f121
https://doi.org/10.5414/cp202324
https://doi.org/10.5414/cp202324
Autor:
Hans Stieltjes, Christopher R. Curtin, Sveta Weiner, Shean-Sheng Wang, Ewa Wajs, Jay Ariyawansa, Nicholas A. Di Prospero, Nicole Vaccaro, Joseph Murphy, Rao N.V.S. Mamidi, Paul Rothenberg, Damayanthi Devineni
Publikováno v:
International Journal of Clinical Pharmacology and Therapeutics
Objective: Canagliflozin, a sodium-glucose co-transporter 2 inhibitor, approved for the treatment of type-2 diabetes mellitus (T2DM), is metabolized by uridine diphosphate-glucuronosyltransferases (UGT) 1A9 and UGT2B4, and is a substrate of P-glycopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834f1e43bf72c1920dbe2be52262a015
https://doi.org/10.5414/cp202158
https://doi.org/10.5414/cp202158
Autor:
Kevin Shalayda, Christopher R. Curtin, Donald Heald, Prasarn Manitpisitkul, Lisa Ford, Shean-Sheng Wang
Publikováno v:
Epilepsy Research. 108:891-901
Topiramate is primarily renally excreted. Chronic renal and hepatic impairment can affect the clearance of topiramate. Therefore, the objective was to establish dosage guidelines for topiramate in chronic renal impairment, end-stage renal disease (ES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc646f8723b8992093c473fa37eb5563
https://doi.org/10.1016/j.eplepsyres.2014.03.011
https://doi.org/10.1016/j.eplepsyres.2014.03.011
Autor:
Shean-Sheng Wang, Lisa Ford, Prasarn Manitpisitkul, Christopher R. Curtin, Kevin Shalayda, Donald Heald
Publikováno v:
Clinical Pharmacology in Drug Development. 3:378-387
Drug-drug interactions between topiramate and diltiazem, hydrochlorothiazide, or propranolol were evaluated along with safety/tolerability in three open-label studies. Healthy participants (aged 18-45 years) received topiramate 75 mg every 12 hours (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21a1581db3414cff3a1bf584f014951
https://doi.org/10.1002/cpdd.107
https://doi.org/10.1002/cpdd.107
Autor:
Hans Stieltjes, Christopher R. Curtin, Hong Tian, Ewa Wajs, Damayanthi Devineni, David Polidori
Publikováno v:
Clinical therapeutics. 38(1)
Purpose Canagliflozin, an orally active selective inhibitor of sodium glucose cotransporter 2, has been approved in several countries for the treatment of type 2 diabetes mellitus. This study assessed the pharmacokinetic (PK) and pharmacodynamic (PD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12863577ece1c00d90dcbef2cabf8ff7
https://pubmed.ncbi.nlm.nih.gov/26687552
https://pubmed.ncbi.nlm.nih.gov/26687552
Autor:
Barry Hafkin, Jaya Natarajan, R. Rex Williams, Cynthia L. Fowler, Lee G. Gisclon, Christopher R. Curtin
Publikováno v:
The Journal of Clinical Pharmacology. 37:744-750
A randomized, placebo-controlled, two-way crossover study in 16 healthy men was performed to determine the effect of orally administered levofloxacin at steady-state conditions, given at 500 mg every 12 hours, on the pharmacokinetics of theophylline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecd6645535d836a7cfcce4c40b14a8e
https://doi.org/10.1002/j.1552-4604.1997.tb04362.x
https://doi.org/10.1002/j.1552-4604.1997.tb04362.x
Autor:
Kevin Shalayda, Donald Heald, Christopher R. Curtin, Shean-Sheng Wang, Lisa Ford, Prasarn Manitpisitkul
Publikováno v:
Epilepsy research. 108(9)
Summary Objective To investigate potential drug–drug interactions between topiramate and metformin and pioglitazone at steady state. Methods Two open-label studies were performed in healthy adult men and women. In Study 1, eligible participants wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a33ceb0e2d1e73ae4e04e1108476e8
https://pubmed.ncbi.nlm.nih.gov/25219351
https://pubmed.ncbi.nlm.nih.gov/25219351
Autor:
Kevin Shalayda, Shean-Sheng Wang, Prasarn Manitpisitkul, Donald Heald, Lisa Ford, Christopher R. Curtin
Publikováno v:
Clinical drug investigation. 33(12)
Topiramate is approved for epilepsy and migraine headache management and has potential antidiabetic activity. Because topiramate and antidiabetic drugs may be co-administered, the potential drug–drug interactions between topiramate and glyburide (g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b24b430759e9d890cc50996247ac2ce
https://pubmed.ncbi.nlm.nih.gov/24132772
https://pubmed.ncbi.nlm.nih.gov/24132772