A new view of macula densa cell microanatomy

Autor: Janos Peti-Peterdi, Kenton P. Arkill, Wilhelm Kriz, Georgina Gyarmati, Anne Riquier-Brison, Brigitte Kaissling, Ju-Young Moon, Nariman Ahmadi, Inderbir S. Gill, Urvi Nikhil Shroff, Dorinne Desposito, Christopher R. Neal

Publikováno v: American Journal of Physiology-Renal Physiology. 320:F492-F504

Although macula densa (MD) cells are chief regulatory cells in the nephron with unique microanatomical features, they have been difficult to study in full detail due to their inaccessibility and limitations in earlier microscopy techniques. The prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c328e7f6a429ff98336dfae75c929067
https://doi.org/10.1152/ajprenal.00546.2020

A role for NPY-NPY2R signaling in albuminuric kidney disease

Autor: Robert G. Nelson, Matthias Kretzler, Abigail C Lay, Viji Nair, Christopher R. Neal, Gavin I. Welsh, Jenny A Hurcombe, Marieangela C. Wilson, Raina D. Ramnath, Philip A. Lewis, A Fern Barrington, Kate J. Heesom, Wenjun Ju, Matthew J. Butler, Craig A. McArdle, Mark A. Graham, Denize Atan, Rebecca M. Perrett, Edward Mountjoy, Richard J M Coward, Simon C. Satchell, Eleanor Herbert

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Lay, A C, Barrington, A F, Hurcombe, J A, Ramnath, R D, Graham, M, Lewis, P A, Wilson, M C, Heesom, K J, Butler, M J, Perrett, R M, Neal, C R, Herbert, E, Mountjoy, E, Atan, D, Nair, V, Ju, W, Nelson, R G, Kretzler, M, Satchell, S C, McArdle, C A, Welsh, G I & Coward, R J M 2020, ' A role for NPY-NPY2R signaling in albuminuric kidney disease ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 202004651, pp. 15862-15873 . https://doi.org/10.1073/pnas.2004651117

Significance Neuropeptide Y (NPY) is implicated in many pathological conditions including obesity, diabetes, and insulin resistance. However, a pathogenic role of NPY in kidney disease has not been described. We found that NPY is produced by the podo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cd8936d1a4b3df29684254bf4466ee
http://europepmc.org/articles/PMC7355002

Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress

Autor: Christopher R. Neal, Bo Su, Angela H. Nobbs, Paul Verkade, Josh J Jenkins, Judith Mantell, Ali Gholinia

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Jenkins, J, Mantell, J, Neal, C, Gholinia, A, Verkade, P, Nobbs, A H & Su, B 2020, ' Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-020-15471-x
Jenkins, J J, Mantell, J M, Neal, C R, Gholinia, A, Verkade, P, Nobbs, A H & Su, B 2020, ' Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress ', Nature Communications, vol. 11, 1626 (2020) . https://doi.org/10.1038/s41467-020-15471-x

Some insects, such as dragonflies, have evolved nanoprotrusions on their wings that rupture bacteria on contact. This has inspired the design of antibacterial implant surfaces with insect-wing mimetic nanopillars made of synthetic materials. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c14ab9820c318c69fa996d2e3ec6c9
https://doaj.org/article/380613ebfa8e43bdb357cc9c3db51d70

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors

Autor: Christopher R. Neal, Natalie Hudson, Nicholas Jones, Louis M. Scott, Emma E. Vincent, Andrew D. Dick, Sofia Theodoropoulou, Ed C. Lavelle, Matthew Campbell, Andrew P. Halestrap

Publikováno v: JCI Insight
Scott, L M, Vincent, E E, Hudson, N, Neal, C R, Jones, N, Lavelle, E C, Campbell, M, Halestrap, A P, Dick, A D & Theodoropoulou, S 2021, ' Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors ', JCI Insight, vol. 6, no. 8, e129429 . https://doi.org/10.1172/jci.insight.129429
JCI Insight, Vol 6, Iss 8 (2021)

It remains unresolved how retinal pigment epithelial cell metabolism is regulated following immune activation to maintain retinal homeostasis and retinal function. We exposed retinal pigment epithelium (RPE) to several stress signals, particularly To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183abb212033545c57e51ffb2994b116
https://doi.org/10.1172/jci.insight.129429

Maintenance of Complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health inC. elegans

Autor: Paul Verkade, Christopher R. Neal, Vicki A. M. Gold, Andrew P. Halestrap, Emma Buzzard, Gonçalo C. Pereira, Amber Knapp-Wilson, Robin A. Corey, Ian Collinson, Patricia E. Kuwabara, Andrew P. Richardson

Mitochondrial super-complexes form around a conserved core of monomeric complex I and dimeric complex III; wherein subunit NDUFA11, of the former, is conspicuously situated at the interface. We identifiedB0491.5(NDUF-11) as theC. eleganshomologue, of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::104e01379c635aa385127605b4103a1c
https://doi.org/10.1101/2021.01.06.425530