Výsledky vyhledávání - "Christopher R, Lopez"

Akademický článek

Ku must load directly onto the chromosome end in order to mediate its telomeric functions.

Autor: Christopher R Lopez, Albert Ribes-Zamora, Sandra M Indiviglio, Christopher L Williams, Svasti Haricharan, Alison A Bertuch

Publikováno v: PLoS Genetics, Vol 7, Iss 8, p e1002233 (2011)

The Ku heterodimer associates with the Saccharomyces cerevisiae telomere, where it impacts several aspects of telomere structure and function. Although Ku avidly binds DNA ends via a preformed channel, its ability to associate with telomeres via this

Externí odkaz: https://doaj.org/article/96f0b3a85efb44979158bc1924f4785e

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Def1 and Dst1 play distinct roles in repair of AP lesions in highly transcribed genomic regions

Autor: Nayun Kim, Norah Owiti, Shivani Singh, Andrei Stephenson, Christopher R. Lopez

Publikováno v: DNA repair. 55

Abasic or AP sites generated by spontaneous DNA damage accumulate at a higher rate in actively transcribed regions of the genome in S. cerevisiae and are primarily repaired by base excision repair (BER) pathway. We have demonstrated that transcriptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf8e92389a7869ae4b589862923d749
https://pubmed.ncbi.nlm.nih.gov/28521214

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Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA

Autor: Nayun Kim, Christopher R. Lopez, Shashank Hambarde, Kevin D. Raney, Jun Gao, Wezley C. Griffin, Yang Yu, Shubeena Chib, Grzegorz Ira, Shivani Singh

Publikováno v: Nucleic Acids Research

G-quadruplex or G4 DNA is a non-B secondary DNA structure consisting of a stacked array of guanine-quartets that can disrupt critical cellular functions such as replication and transcription. When sequences that can adopt Non-B structures including G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798db52701ea00230f4ea9786de623d5
https://pubmed.ncbi.nlm.nih.gov/28369605

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Quorum sensing and multidrug transporters in Escherichia coli

Autor: Lynn Zechiedrich, Shirley Yang, Christopher R. Lopez

Publikováno v: Proceedings of the National Academy of Sciences. 103:2386-2391

Previously, we found that the quorum sensing transcription factor SdiA up-regulates AcrAB. Others found that a 4-quinolone was a quorum-sensing signal in Pseudomonas aeruginosa . In Escherichia coli , there are at least three multidrug transporters (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7691729f6bdcd4a853e1ccddabf184a
https://doi.org/10.1073/pnas.0502890102

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A role for topoisomerase III in a recombination pathway alternative to RuvABC

Autor: Russell J. DiGate, P. J. Hastings, Richard W. Deibler, Jeanine M. Pennington, Christopher R. Lopez, Starlight A. Ray, Shirley Yang, Susan M. Rosenberg, Lynn Zechiedrich

Publikováno v: Molecular Microbiology. 58:80-101

The physiological role of topoisomerase III is unclear for any organism. We show here that the removal of topoisomerase III in temperature sensitive topoisomerase IV mutants in Escherichia coli results in inviability at the permissive temperature. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e05156bcbd512ecd8c0cd7ff9aaebe95
https://doi.org/10.1111/j.1365-2958.2005.04812.x

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Regulation of Ku-DNA Association by Yku70 C-terminal Tail and SUMO Modification*

Autor: Alison A. Bertuch, Christopher R. Lopez, Inn Chung, Jaime M. Williams, Lei Wei, Xiaolan Zhao, Lisa E. Hang, Xianpeng Liu

The Ku70-Ku80 ring complex encloses DNA ends to facilitate telomere maintenance and DNA break repair. Many studies focus on the ring-forming regions of subunits Ku70 and Ku80. Less is known about the Ku70 C-terminal tail, which lies outside the ring.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55339d133e8abdfb37b9d52d5cde0c9
https://europepmc.org/articles/PMC4036155/