Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christopher Plumpton"'
Publikováno v:
British Journal of Pharmacology. 128:135-141
1. Chronic selective beta1-adrenoceptor (beta1AR) blocker treatment enhances the sensitivity of beta2-adrenoceptor (beta2AR) in human heart (Hall et al., 1990; 1991). To clarify the mechanism of the cross-sensitization between beta1AR and beta2AR, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bdd7b29a4b2795e8e0c93a394b3c148
https://doi.org/10.1038/sj.bjp.0702750
https://doi.org/10.1038/sj.bjp.0702750
Autor:
Neville S. Huskisson, Christopher Plumpton, James W. Mockridge, Anthony P. Davenport, Rhoda E. Kuc, Patrick J. Barker
Publikováno v:
The Histochemical Journal. 30:359-374
Our aim was to determine whether the expression of endothelin-converting enzyme in human tissues would correlate with the distribution of its substrate, big endothelin-1, and its product, the mature peptide. Site-directed antisera raised against the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6df831569d05172d2cc48cfa64a980
https://doi.org/10.1023/a:1003236628701
https://doi.org/10.1023/a:1003236628701
Publikováno v:
Europe PubMed Central
1. We have examined the expression of endothelin isoforms and their precursors in the human heart using RIA, HPLC, immunocytochemistry and reverse transcriptase—polymerase chain reaction assays. 2. Highly specific RIAs were used to measure the leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008e92f33fe9991f26166d49025bcaec
https://doi.org/10.1042/cs0900037
https://doi.org/10.1042/cs0900037
Publikováno v:
Clinical Science. 87:245-251
1. Two-site enzyme-linked immunosorbent assays have been developed for the rapid, sensitive and non-isotopic measurement of endothelin-1 and big endothelin-1. The sensitivities of detection were 0.5 and 0.3 fmol/well, with ED50 values of 13 and 12 fm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f21a61c25b891b4852244b1b313c590
https://doi.org/10.1042/cs0870245
https://doi.org/10.1042/cs0870245
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:S34-36
We developed a procedure for individual measurement of big endothelin-1 (big ET-1) and the two products of big ET-1 conversion (ET-1 and C-terminal fragment (CTF) of big ET-I (big ET-1 22-38 ), using selective solid-phase extraction and specific radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db49d8f5f7710f62f17ddd4087b28471
https://doi.org/10.1097/00005344-199506263-00011
https://doi.org/10.1097/00005344-199506263-00011
Autor:
Patricia Viard, Annette C. Dolphin, Karen M. Page, Anthony Davies, Mary Plumpton, Fraser J. Moss, Federica Bertaso, Jeffrey J. Clare, Christopher Plumpton, C Canti, Alex Graham
We have cloned and characterized a new member of the voltage-dependent Ca(2+) channel gamma subunit family, with a novel gene structure and striking properties. Unlike the genes of other potential gamma subunits identified by their homology to the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4a729ee35335ae656e40e6e45b3c1d
https://europepmc.org/articles/PMC125363/
https://europepmc.org/articles/PMC125363/
Autor:
Michael P Love, Charles J. Ferro, David J. Webb, Anthony P. Davenport, Christopher Plumpton, William G. Haynes, John J.V. McMurray
Publikováno v:
Cardiovascular research. 47(1)
Objective: The relative importance of ETA and ETB receptors in mediating the constrictor effects of endogenous endothelin-1 in patients with chronic heart failure is not known. The primary purpose of this study was to compare the acute effects of sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b725b2b8028d52d60356523692d6b7a7
https://pubmed.ncbi.nlm.nih.gov/10869543
https://pubmed.ncbi.nlm.nih.gov/10869543
Autor:
William G. Haynes, Charles J. Ferro, Anthony P. Davenport, David J. Webb, Christopher Plumpton
Publikováno v:
British journal of pharmacology. 119(2)
1. We examined the effects of systemic infusion, in healthy human volunteers, of the endothelin antagonist TAK-044 on the plasma concentrations of mature endothelin, big endothelin-1 and the C-terminal fragment of big endothelin-1, by selective solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca426347a110e649b266048c0cf61955
https://pubmed.ncbi.nlm.nih.gov/8886414
https://pubmed.ncbi.nlm.nih.gov/8886414
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 240(2)
A panel of six monoclonal antibodies (MAbs) was raised against purified human fibroblast tissue inhibitor of metalloproteinase-1 (TIMP-1) and characterised. All possible antibody pairs were tested for their suitability as capture and revealing antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1c714ec80234c46e3b888ee84b8222
https://pubmed.ncbi.nlm.nih.gov/8548924
https://pubmed.ncbi.nlm.nih.gov/8548924
Publikováno v:
British journal of pharmacology. 116(2)
1 The vasoconstrictor peptide, endothelin-1 (ET-1) and a biologically inactive C-terminal fragment (CTF) are generated from an intermediate big ET-1 by a putative ET converting enzyme, sensitive to phosphoramidon. We have developed a procedure using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae713e539e503ca8ae29fcf855d380e
https://pubmed.ncbi.nlm.nih.gov/8528566
https://pubmed.ncbi.nlm.nih.gov/8528566