Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Christopher P. Toseland"'
Autor:
Ália dos Santos, Daniel E. Rollins, Yukti Hari-Gupta, Hannah McArthur, Mingxue Du, Sabrina Yong Zi Ru, Kseniia Pidlisna, Ane Stranger, Faeeza Lorgat, Danielle Lambert, Ian Brown, Kevin Howland, Jesse Aaron, Lin Wang, Peter J. I. Ellis, Teng-Leong Chew, Marisa Martin-Fernandez, Alice L. B. Pyne, Christopher P. Toseland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in the nucleus and is expressed throughout the cell, to date, there is no clear nucl
Externí odkaz:
https://doaj.org/article/7f493cd90a81442ab6f20bf8a272b5ba
Autor:
Yukti Hari-Gupta, Natalia Fili, Ália dos Santos, Alexander W. Cook, Rosemarie E. Gough, Hannah C. W. Reed, Lin Wang, Jesse Aaron, Tomas Venit, Eric Wait, Andreas Grosse-Berkenbusch, J. Christof M. Gebhardt, Piergiorgio Percipalle, Teng-Leong Chew, Marisa Martin-Fernandez, Christopher P. Toseland
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The actin-based molecular motors, myosins, have also been linked to transcription, but their precise role has remained elusive. Here the authors show RNA polymerase II (RNAPII) is lost from chromatin upon myosin perturbation and that myosin acts as a
Externí odkaz:
https://doaj.org/article/fa69ba5631c84cc1bb9164996b3d0270
Autor:
Natalia Fili, Yukti Hari-Gupta, Ália dos Santos, Alexander Cook, Simon Poland, Simon M. Ameer-Beg, Maddy Parsons, Christopher P. Toseland
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear rece
Externí odkaz:
https://doaj.org/article/14b2334ce9e44248852b7f5d9eafede6
Autor:
Michael Lherbette, Ália dos Santos, Yukti Hari-Gupta, Natalia Fili, Christopher P. Toseland, Iwan A. T. Schaap
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract During growth, differentiation and migration of cells, the nucleus changes size and shape, while encountering forces generated by the cell itself and its environment. Although there is increasing evidence that such mechanical signals are emp
Externí odkaz:
https://doaj.org/article/238f6000e7a14ac5ab9064a834e36ab6
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3178 (2021)
In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical properties of the nucleus and its ability to sense external mechanical cues are tightly linked to the regulation of cellular events, such as gene expression. Nucle
Externí odkaz:
https://doaj.org/article/657e00c52ea84f81b56667e6e7bc6ec2
Autor:
Ioannis Emmanouilidis, Natalia Fili, Alexander W. Cook, Yukti Hari-Gupta, Ália dos Santos, Lin Wang, Marisa L. Martin-Fernandez, Peter J. I. Ellis, Christopher P. Toseland
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 288 (2021)
Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular mechanisms of the DNA damage response allows the development of therapeutics which target ele
Externí odkaz:
https://doaj.org/article/9bf91830afad4a3696f861d1728a01cd
Autor:
Mingxi Yao, Benjamin T. Goult, Benjamin Klapholz, Xian Hu, Christopher P. Toseland, Yingjian Guo, Peiwen Cong, Michael P. Sheetz, Jie Yan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can functi
Externí odkaz:
https://doaj.org/article/bab088eae21c4aa09d879414bfbc9a59
Publikováno v:
Biochemical Society Transactions.
The importance of myosin motor protein is well-characterised within the cytoplasm and cytoskeleton. However, mounting evidence on four nuclear myosins highlights the central role these proteins have in maintaining genomic stability and gene expressio
Autor:
Raquel González-Novo, Héctor Zamora-Carreras, Ana de Lope-Planelles, Horacio López- Menéndez, Pedro Roda-Navarro, Francisco Monroy, Lin Wang, Christopher P. Toseland, Javier Redondo Muñoz
The interplay between cells and their surrounding microenvironment drives multiple cellular functions, including migration, proliferation, and cell fate transitions. The nucleus is a mechanosensitive organelle that adapts external mechanical and bioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45f89c2babdef641324991f0e02204a2
https://doi.org/10.1101/2023.04.10.536202
https://doi.org/10.1101/2023.04.10.536202
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2476
Super-resolution microscopy enables the high-precision localization of proteins. Therefore, it is possible to investigate the spatial organization of proteins within the nucleus to understand how their organization relates to regulation and function.