Specialization of actin isoforms derived from the loss of key interactions with regulatory factors

Autor: Micaela Boiero Sanders, Christopher P Toret, Audrey Guillotin, Adrien Antkowiak, Thomas Vannier, Robert C Robinson, Alphée Michelot

Publikováno v: EMBO Journal
EMBO Journal, 2022, 41 (5), ⟨10.15252/embj.2021107982⟩

International audience; A paradox of eukaryotic cells is that while some species assemble a complex actin cytoskeleton from a single ortholog, other species utilize a greater diversity of actin isoforms. The physiological consequences of using differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb30d06de9764af3593ab8b726c5c7be
https://hal.science/hal-03863041

A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions

Autor: André Le Bivic, Christopher P. Toret

Publikováno v: Small GTPases
Small GTPases, Taylor & Francis, 2018, pp.1-7. ⟨10.1080/21541248.2018.1502592⟩
Small GTPases, 2021, 12 (1), pp.13-19. ⟨10.1080/21541248.2018.1502592⟩
Small GTPases, 2018, pp.1-7. ⟨10.1080/21541248.2018.1502592⟩
Small GTPases, Taylor & Francis, 2021, 12 (1), pp.13-19. ⟨10.1080/21541248.2018.1502592⟩

International audience; The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6c2ec6777e4e242a11c90912079be9
https://hal.archives-ouvertes.fr/hal-01973878

The elmo-mbc complex and rhogap19d couple Rho family GTPases during mesenchymal-to-epithelial-like transitions

Autor: Pruthvi Chavadimane Shivakumar, André Le Bivic, Christopher P. Toret, Pierre-François Lenne

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2018, 145 (4), pp.dev157495. ⟨10.1242/dev.157495⟩
Development (Cambridge, England), 2018, 145 (4), pp.dev157495. ⟨10.1242/dev.157495⟩

International audience; Many metazoan developmental processes require cells to transition between migratory mesenchymal- and adherent epithelial-like states. These transitions require Rho GTPase-mediated actin rearrangements downstream of integrin an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a0990cddd5492c3dd47634cb15fb44
https://pubmed.ncbi.nlm.nih.gov/29437779

Early-Arriving Syp1p and Ede1p Function in Endocytic Site Placement and Formation in Budding Yeast

Autor: Christopher P. Toret, Barbara Pauly, Helen E. M. Stimpson, Aaron T. Cheng, David G. Drubin

Publikováno v: Molecular Biology of the Cell. 20:4640-4651

Recent studies have revealed the detailed timing of protein recruitment to endocytic sites in budding yeast. However, little is understood about the early stages of their formation. Here we identify the septin-associated protein Syp1p as a component

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4384a41ccc059a4d642a8c5055691cbe
https://doi.org/10.1091/mbc.e09-05-0429

Two binding partners cooperate to activate the molecular motor Kinesin-1

Autor: Dawen Cai, Kristen J. Verhey, Christopher P. Toret, T. Lynne Blasius, Gloria T. Jih

Publikováno v: The Journal of Cell Biology

The regulation of molecular motors is an important cellular problem, as motility in the absence of cargo results in futile adenosine triphosphate hydrolysis. When not transporting cargo, the microtubule (MT)-based motor Kinesin-1 is kept inactive as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2c9029260ac5b4bc651b8f8ca3baf7
https://doi.org/10.1083/jcb.200605099