Acquired Nisin Resistance in Staphylococcus aureus Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module

Autor: Christopher P. Randall, Arya Gupta, Bret Utley-Drew, Siu Yi Lee, Genevieve Morrison-Williams, Alex J. O’Neill

Publikováno v: mSphere, Vol 3, Iss 6 (2018)

ABSTRACT Resistance to the lantibiotic nisin (NIS) arises readily in Staphylococcus aureus as a consequence of mutations in the nsaS gene, which encodes the sensor kinase of the NsaRS two-component regulatory system. Here we present a series of studi

Externí odkaz: https://doaj.org/article/9b03415a9c534106a0f35536e02051d2

A platform for detecting cross-resistance in antibacterial drug discovery

Autor: Luiza H Galarion, Christopher P. Randall, Merianne Mohamad, Alex J. O'Neill, Zeyad Alzeyadi

Publikováno v: The Journal of antimicrobial chemotherapy. 76(6)

Background To address the growing antibiotic resistance problem, new antibacterial drugs must exert activity against pathogens resistant to agents already in use. With a view to providing a rapid means for deselecting antibacterial drug candidates th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e6f92fcada8d3057fea477275ce72a
https://pubmed.ncbi.nlm.nih.gov/33755133

Transient silencing of antibiotic resistance by mutation represents a significant potential source of unanticipated therapeutic failure

Autor: Francesc Coll, Louise Kime, Julian Parkhill, Alex J. O'Neill, John Wright, Joseph Richardson, Christopher P. Randall, Frank I. Banda, Joanna Empel

Publikováno v: mBio, Vol 10, Iss 5 (2019)
mBio
mBio, Vol 10, Iss 5, p e01755-19 (2019)

Antibiotic resistance hinders the treatment of bacterial infection. To guide effective therapy, clinical microbiology laboratories routinely perform susceptibility testing to determine the antibiotic sensitivity of an infecting pathogen. This approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cfa6e6a8758bca414d4544e3808ed4
https://eprints.whiterose.ac.uk/151933/5/VOR.pdf

N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors

Autor: Marina Madre, Wil H. F. Goessens, Adélaïde Saint-Léger, Kristaps Jaudzems, Paul W. Finn, Rihards Aleksis, Louise Kime, Alex J. O'Neill, Lluís Ribas de Pouplana, Arya Gupta, Aigars Jirgensons, Daina Gustina, Edmund Grace, Michael H. Charlton, Christopher P. Randall, Einars Loza, Daina Lola, Ilze Kaula

Publikováno v: ACS Medicinal Chemistry Letters, 9(2), 84-88. American Chemical Society

N-Leucinyl benzenesulfonamides have been discovered as a novel class of potent inhibitors of E. coli leucyl-tRNA synthetase. The binding of inhibitors to the enzyme was measured by using isothermal titration calorimetry. This provided information on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3148ecaf4ee91fd30ad3e156cbc3a20b
https://europepmc.org/articles/PMC5807874/

Impact of Exposure of Methicillin-Resistant Staphylococcus aureus to Polyhexanide In Vitro and In Vivo

Autor: Jacques Schrenzel, Abdessalam Cherkaoui, Alex J. O'Neill, Patrice Francois, Caroline Landelle, A. S. Bayer, Adriana Renzoni, Damien Baud, Stéphan Juergen Harbarth, E. von Dach, Seydina M. Diene, E-J Bonetti, Christopher P. Randall, R. Gonzales, Wessam Abdelhady, Caroline Manzano

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (10)
Antimicrobial Agents and Chemotherapy, Vol. 61, No 10 (2017) pp. e00272-17

Methicillin-resistant Staphylococcus aureus (MRSA) resistant to decolonization agents such as mupirocin and chlorhexidine increases the need for development of alternative decolonization molecules. The absence of reported severe adverse reactions and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ac8abb14481014a4156992fe93fa63
https://hal.univ-grenoble-alpes.fr/hal-02012401