Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christopher P. Mintoff"'
Autor:
Zhi Ling Teo, Mark J. O’Connor, Stephanie Versaci, Kylie A. Clarke, Emmaline R. Brown, Luke W. Percy, Keilly Kuykhoven, Christopher P. Mintoff, Peter Savas, Balaji Virassamy, Stephen J. Luen, Ann Byrne, Sneha Sant, Geoffrey J. Lindeman, Phillip K. Darcy, Sherene Loi
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract Novel therapeutic strategies that can effectively combine with immunotherapies are needed in the treatment of triple-negative breast cancer (TNBC). We demonstrate that combined PARP and WEE1 inhibition are synergistic in controlling tumour g
Externí odkaz:
https://doaj.org/article/bce6df774b064a2787512a67c74201f2
Autor:
Ismael A. Vergara, Christopher P. Mintoff, Shahneen Sandhu, Lachlan McIntosh, Richard J. Young, Stephen Q. Wong, Andrew Colebatch, Daniel L. Cameron, Julia Lai Kwon, Rory Wolfe, Angela Peng, Jason Ellul, Xuelin Dou, Clare Fedele, Samantha Boyle, Gisela Mir Arnau, Jeanette Raleigh, Athena Hatzimihalis, Pacman Szeto, Jennifer Mooi, Daniel S. Widmer, Phil F. Cheng, Valerie Amann, Reinhard Dummer, Nicholas Hayward, James Wilmott, Richard A. Scolyer, Raymond J. Cho, David Bowtell, Heather Thorne, Kathryn Alsop, Stephen Cordner, Noel Woodford, Jodie Leditschke, Patricia O’Brien, Sarah-Jane Dawson, Grant A. McArthur, Graham J. Mann, Mitchell P. Levesque, Anthony T. Papenfuss, Mark Shackleton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The genetic changes that occur in late stage metastatic melanoma are not well delineated. Here, the authors use rapid autopsy samples from metastatic melanoma patients and show that the late stage in the disease is characterised by whole genome doubl
Externí odkaz:
https://doaj.org/article/4c17fb9d0e02463397deea2b50e28d35
Autor:
Sathana Dushyanthen, Zhi Ling Teo, Franco Caramia, Peter Savas, Christopher P. Mintoff, Balaji Virassamy, Melissa A. Henderson, Stephen J. Luen, Mariam Mansour, Michael H. Kershaw, Joseph A. Trapani, Paul J. Neeson, Roberto Salgado, Grant A. McArthur, Justin M. Balko, Paul A. Beavis, Phillip K. Darcy, Sherene Loi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
MEK inhibition in breast cancer is associated with increased tumour infiltrating lymphocytes (TILs), however, MAPK activity is required for T cells function. Here the authors show that TILs activity following MEK inhibition can be enhanced by agonist
Externí odkaz:
https://doaj.org/article/9dca7cf8454b4a3b9462fc4df89bf7de
Autor:
Ken Doig, Andrew J. Colebatch, Devbarna Sinha, Christopher P. Mintoff, Grant A. McArthur, Paul Yeh, Carleen Cullinane, Maria Joao Silva, Shahneen Sandhu, David E. Gyorki, Mark Shackleton, Kathryn Alsop, Gisela Mir Arnau, Anthony T. Papenfuss, Sarah Ftouni, David D.L. Bowtell, Jason Li, Sarah-Jane Dawson, Jeanette Raleigh, Fergal C. Kelleher, Athena Hatzimihalis, Benjamin Brady, Mark A. Dawson, Stephen Q. Wong, Rodney J. Hicks, Heather Thorne, Jason Callahan, Damien Kee, Ismael A. Vergara, Timothy Semple
Publikováno v:
JCO precision oncology. 1
Purpose Circulating tumor DNA (ctDNA) allows noninvasive disease monitoring across a range of malignancies. In metastatic melanoma, the extent to which ctDNA reflects changes in metabolic disease burden assessed by 18F-labeled fluorodeoxyglucose posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0dc9da911dfeb579d61276aa6daaa3
https://pubmed.ncbi.nlm.nih.gov/35172485
https://pubmed.ncbi.nlm.nih.gov/35172485
Autor:
Helen Rizos, Evangeline Shaw, Lachlan McIntosh, Mark Shackleton, Jian-Zhong Tang, Katrina A. Mitchell, Grant A. McArthur, Andrew J. Colebatch, Xiaomeng Zhang, Kieran F. Harvey, Georgina V. Long, Lie Yang, Nicholas K. Hayward, Pacman Szeto, Christopher P. Mintoff, Ismael A. Vergara, Youfang Zhang, Anthony T. Papenfuss
Publikováno v:
Molecular Cancer Research. 17:1435-1449
Melanoma is usually driven by mutations in BRAF or NRAS, which trigger hyperactivation of MAPK signaling. However, MAPK-targeted therapies are not sustainably effective in most patients. Accordingly, characterizing mechanisms that co-operatively driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deaa2c5c9dc5f22e13bc9c89419637db
https://doi.org/10.1158/1541-7786.mcr-18-0407
https://doi.org/10.1158/1541-7786.mcr-18-0407
Autor:
Andrew J. Colebatch, Anthony T. Papenfuss, Clare G Fedele, Nicholas K. Hayward, Pacman Szeto, Jodie Leditschke, Richard A. Scolyer, Jennifer Mooi, Raymond J. Cho, Athena Hatzimihalis, Daniel L Cameron, Heather Thorne, Jason Ellul, Mitchell P. Levesque, Stephen Cordner, Grant A. McArthur, Noel Woodford, Julia Lai Kwon, Phil F. Cheng, Sarah-Jane Dawson, Reinhard Dummer, Rory Wolfe, Kathryn Alsop, Mark Shackleton, Angela Peng, Daniel S. Widmer, Gisela Mir Arnau, Jeanette Raleigh, Richard J. Young, Valerie C Amann, Ismael A. Vergara, Lachlan McIntosh, Shahneen Sandhu, James S. Wilmott, Xuelin Dou, Stephen Q. Wong, Graham J. Mann, Patricia C. M. O’Brien, Christopher P. Mintoff, David D.L. Bowtell, Samantha E. Boyle
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origin, the nature of genetic changes that characterise lethal metastatic disease is poorly understood. Here, we analyze the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e1e4cf2ed12438734baa842912b9a5
http://europepmc.org/articles/PMC7933255
http://europepmc.org/articles/PMC7933255
Autor:
Chantel M Thornton, Stephen B. Fox, Paul A. Beavis, Chengzhong Ye, Catherine Poliness, Balaji Virassamy, Phillip K. Darcy, David J Byrne, Ann Byrne, Zhi Ling Teo, Terence P. Speed, Stephen J Luen, David E. Gyorki, Christopher P. Mintoff, Lironne Wein, Peter Savas, Anita S Skandarajah, Sherene Loi, Paul J Neeson, Laura K. Mackay, Sophie Nightingale, Roberto Salgado, Agus Salim, Sathana Dushyanthen, Franco Caramia
Publikováno v:
Nature medicine. 24(7)
The quantity of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is a robust prognostic factor for improved patient survival, particularly in triple-negative and HER2-overexpressing BC subtypes1. Although T cells are the predominant TIL po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862afd8570cf87417608dcd6ecb22be6
https://pubmed.ncbi.nlm.nih.gov/30135555
https://pubmed.ncbi.nlm.nih.gov/30135555
Autor:
Paul J Neeson, Phillip K. Darcy, Sathana Dushyanthen, Roberto Salgado, Balaji Virassamy, Grant A. McArthur, Justin M. Balko, Stephen J Luen, Michael H. Kershaw, Paul A. Beavis, Peter Savas, Zhi Ling Teo, Melissa A. Henderson, Christopher P. Mintoff, Joseph A. Trapani, Franco Caramia, Mariam Mansour, Sherene Loi
Publikováno v:
Nature communications, 8 (1
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is associated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba3b5e19d964d6ca3228e766a16be03
https://doi.org/10.1038/s41467-017-00728-9
https://doi.org/10.1038/s41467-017-00728-9
Autor:
Antonia N. Policheni, Christopher P. Mintoff, Stephen B. Fox, Jane E. Visvader, Geoffrey J. Lindeman, Sherene Loi, Daniel H.D. Gray, Sathana Dushyanthen, Mariam Mansour, Emma Nolan, Jia-Min B Pang, François Vaillant, Charles M. Perou, Peter Savas, Phillip K. Darcy
Immune checkpoint inhibitors have emerged as a potent new class of anticancer therapy. They have changed the treatment landscape for a range of tumors, particularly those with a high mutational load. To date, however, modest results have been observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63807d87bdf0a08570fa9c30f1f2985
https://europepmc.org/articles/PMC5822709/
https://europepmc.org/articles/PMC5822709/
Autor:
Paul J Neeson, Agus Salim, Terence P. Speed, Zhi Ling Teo, Sathana Dushyanthen, Stephen B. Fox, Balaji Virassamy, Ann Byrne, Stephen J Luen, Christopher P. Mintoff, Sherene Loi, Peter Savas, Chengzhong Ye, Franco Caramia, Laura K. Mackay, Roberto Salgado
Publikováno v:
Cancer Research. 79:PD5-03
Background: Tumor infiltrating lymphocytes (TILs) assessed via light microscopy are prognostic and predictive in the early stage and advanced triple negative and HER2-amplified breast cancer (BC). Higher TILs can also identify patients more likely to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb9d710495570786cb1f1f73f33ec93
https://doi.org/10.1158/1538-7445.sabcs18-pd5-03
https://doi.org/10.1158/1538-7445.sabcs18-pd5-03