Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Christopher P. Loo"'
Autor:
Christopher P. Loo, Nicholas A. Nelson, Ryan S. Lane, Jamie L. Booth, Sofia C. Loprinzi Hardin, Archana Thomas, Mark K. Slifka, Jeffrey C. Nolz, Amanda W. Lund
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3176-3187 (2017)
Lymphatic vessels lie at the interface between peripheral sites of pathogen entry, adaptive immunity, and the systemic host. Though the paradigm is that their open structure allows for passive flow of infectious particles from peripheral tissues to l
Externí odkaz:
https://doaj.org/article/583a95819dd04ca3bbd3ef5cf647b77c
Autor:
Kyle A. Romine, Kevin MacPherson, Hyun-jun Cho, Yoko Kosaka, Patrick A. Flynn, Kaelan H. Byrd, Jesse L. Coy, Matthew T. Newman, Ravina Pandita, Christopher P. Loo, Jaime Scott, Andrew C. Adey, Evan F. Lind
Publikováno v:
Leukemia. 37:580-592
Many acute myeloid leukemia (AML) patients exhibit hallmarks of immune exhaustion, such as increased myeloid-derived suppressor cells, suppressive regulatory T cells and dysfunctional T cells. Similarly, we have identified the same immune-related fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4909f16696e08a70a1f9f2595cf834
https://doi.org/10.1038/s41375-023-01808-0
https://doi.org/10.1038/s41375-023-01808-0
Autor:
Matthew T. Newman, Jaime Scott, Evan F. Lind, Jesse L. Coy, Hyun-jun Cho, Kaelan Byrd, Christopher P. Loo, Kyle A. Romine, Patrick A. Flynn, Yoko Kosaka
Many acute myeloid leukemia (AML) patients exhibit hallmarks of immune exhaustion, such as increased myeloid derived suppressor cells (MDSCs), suppressive regulatory T cells (Tregs) and dysfunctional T cells. We have developed a mouse model of AML dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e20a348eca2dc8dca0a80900b7efe7
https://doi.org/10.1101/2021.08.04.455147
https://doi.org/10.1101/2021.08.04.455147
Autor:
Yoko Kosaka, Matthew T. Newman, Kyle A. Romine, Patrick J. Flynn, Jesse L. Coy, Evan F. Lind, Christopher P. Loo, Kaelan Byrd, Hyun-jun Cho
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundAcute Myeloid Leukemia (AML) is the most common adult leukemia and has a very poor prognosis. With a 5-year survival of under 30% (seer.cancer.gov), most people diagnosed with AML will die from the disease. AML is caused by an uncontrolled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec64e70687144bfa27f1812e7920fc0
https://doi.org/10.1136/jitc-2021-sitc2021.734
https://doi.org/10.1136/jitc-2021-sitc2021.734
Autor:
Amanda W. Lund, Ryan S. Lane, Young Hwan Chang, Julia Femel, Alec P. Breazeale, Takahiro Tsujikawa, Christopher P. Loo, Andy Kaempf, Motomi Mori, Guillaume Thibault
Publikováno v:
Journal of Experimental Medicine. 215:3057-3074
Mechanisms of immune suppression in peripheral tissues counteract protective immunity to prevent immunopathology and are coopted by tumors for immune evasion. While lymphatic vessels facilitate T cell priming, they also exert immune suppressive effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfa96faf26d535edc9fea8d27f4595c
https://doi.org/10.1084/jem.20180654
https://doi.org/10.1084/jem.20180654
Autor:
Christopher P Loo
Publikováno v:
The Journal of Immunology. 204:243.27-243.27
The mechanisms of targeted-immunotherapy are still at the beginning stages for blood tumors. In the current era of big data and genomic sequencing, evolving bioinformatic tools are need for the validation and prediction of current and future immunoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8191e5fa3f3407ce0ea277e5b7f53c
https://doi.org/10.4049/jimmunol.204.supp.243.27
https://doi.org/10.4049/jimmunol.204.supp.243.27
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 198(1)
Increasing amounts of pathogen replication usually lead to a proportionate increase in size and effector differentiation of the CD8+ T cell response, which is attributed to increased Ag and inflammation. Using a murine CMV that is highly sensitive to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aefe24623becdbf88265f6408f9bdd
https://pubmed.ncbi.nlm.nih.gov/27872208
https://pubmed.ncbi.nlm.nih.gov/27872208
Autor:
Johan K. Sandberg, Jennifer E. Snyder-Cappione, Jakob Michaëlsson, Veronica D. Gonzalez, Gerald Spotts, Brian Long, Christopher P. Loo, Douglas F. Nixon, Carlotta Kuylenstierna, Frederick Hecht, Markus Moll
Publikováno v:
Scandinavian Journal of Immunology. 73:141-146
Cytokine immunotherapy is being evaluated as adjunct treatment in infectious diseases. The effects on innate and adaptive immunity in vivo are insufficiently known. Here, we investigate whether combination treatment with antiretroviral therapy (ART)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa4e2fc854309089d3e75cfff0824476
https://doi.org/10.1111/j.1365-3083.2010.02484.x
https://doi.org/10.1111/j.1365-3083.2010.02484.x
Autor:
Johan K. Sandberg, Steven G. Deeks, Michael G. Rosenberg, Esper G. Kallas, Jennifer E. Snyder-Cappione, Douglas F. Nixon, Carlotta Kuylenstierna, Frederick Hecht, Karina I. Carvalho, Christopher P. Loo
Publikováno v:
AIDS. 23:1965-1970
Objective: Natural killer T (NKT) cells are efficiently targeted by HIV and severely reduced in numbers in the circulation of infected individuals. The functional capacityof the remaining NKT cells in HIV-infected individuals is poorly characterized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df18dfdf80fc32fa70402be6c6d53b7
https://doi.org/10.1097/qad.0b013e32832b5134
https://doi.org/10.1097/qad.0b013e32832b5134
Autor:
Jakob Michaëlsson, Lewis L. Lanier, Gerald Spotts, Brian Long, Frederick Hecht, Christopher P. Loo, Douglas F. Nixon
Publikováno v:
The Journal of Infectious Diseases. 197:117-125
Natural killer (NK) cells are believed to play a role in human immunodeficiency virus type 1 (HIV-1) disease progression, and NK cell levels are reduced in individuals with chronic HIV-1 infection. Interleukin (IL)-2 therapy results in an expansion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b348fa8c7ecb3119bc6269a9a4175b1
https://doi.org/10.1086/524141
https://doi.org/10.1086/524141