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pro vyhledávání: '"Christopher P. Ley"'
Autor:
Marcos E. Orchard, Christopher P. Ley
Publikováno v:
IFAC-PapersOnLine. 51:214-220
In Lithium-Ion batteries, the polarising impedance is an important characteristic that has been shown to be a complex function of, among others, both the state of charge and the demanded current. Therefore within a prognostic framework, which typical
Publikováno v:
Journal of Energy Storage. 40:102735
State-of-Charge (SoC) is commonly defined as a ratio between the available charge and the battery capacity. Unfortunately, SoC has been misguidedly interpreted as an indicator of autonomy. Despite its widespread use, this concept has two critical fla
Autor:
Marcos E. Orchard, Christopher P. Ley
Publikováno v:
Mechanical Systems and Signal Processing
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
This paper presents a novel form of selecting the likelihood function of the standard sequential importance sampling/re-sampling particle filter (SIR-PF) with a combination of sliding window smoothing and chi-square statistic weighting, so as to: (a)
Autor:
Marcos E. Orchard, Christopher P. Ley
Publikováno v:
Journal of Energy Storage. 36:102370
In this article we present a Hybrid Neural Adaptive State Space Model (NASSM), the purpose of which is to solve the complex problem of accurately characterising the ever changing (non-measurable) polarising impedance multi-dimensional surface and cap
Autor:
Jeffrey Thomas Vicenzi, Paul A. Stroud, Gregory A. Rener, Gregory A. Stephenson, Marie Kissane, Scott Alan Frank, Radhe K. Vaid, Sathish K. Boini, Charles A. Alt, Laura A. McKee, Christopher P. Ley
Publikováno v:
Tetrahedron Letters. 54:6587-6591
The identification and development of an aldehyde–bisulfite adduct as an isolable starting material in the synthesis of the CETP inhibitor Evacetrapib are described. The physical properties of the sodium and potassium analogs are compared, and the
Autor:
Jacob R. Remacle, Amy C. DeBaillie, Christopher P. Ley, Thomas Michael Wilson, Nicholas A. Magnus, Varie David Lee, Perry Clark Heath, Timothy M. Braden, Jonas Y. Buser
Publikováno v:
Organic Process Research & Development. 16:830-835
This article describes the development and optimization of chemical reactions and subsequent multikilogram preparation of the glucokinase activator (R)-1 to fund clinical evaluation as a potential therapeutic for type II diabetes. The major process d
Publikováno v:
Organic Letters. 12:3700-3703
A practical synthesis of the glycogen synthase kinase-3 (GSK3) inhibitor bisarylmaleimide 1 has been accomplished employing Pictet-Spengler methodology to access the indole 7-position in preparing the benzodiazepine tricyclic fragment. A seven-step l
Publikováno v:
Organic Process Research & Development. 13:268-275
An efficient, scalable synthesis of the multipotent eicosanoid pathway modulator 2-[3-[3[[5-ethyl-4′-fluoro-2-hydroxyl[1,1′-biphenyl]-4-yl]oxy]-propoxy]2-propoxylphenoxy]benzoic acid (1) is described. The process consists of nine chemical steps w
Publikováno v:
Organic Process Research & Development. 13:255-262
The synthesis of 5-bromo-thiophene-2-sulfonic acid 2,4-dichlorobenzoylamide sodium salt on multikilogram scale is described. The initial clinical supplies were made using carbonyl diimidazole to converge the two fragments. A more efficient acid chlor
Autor:
Christopher P. Ley, Matthew H. Yates
Publikováno v:
Organic Process Research & Development. 12:120-124
A practical and efficient method to purify 2,4-dichlorobenzoic acid is described. The formation of an α-methylbenzylamine salt reduces the levels of positional isomer impurities to