Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher P. Hebbes"'
Autor:
Mark F. Bird, Christopher P. Hebbes, Anushuya Tamang, Jonathon Mark Willets, Jonathan P. Thompson, Remo Guerrini, Girolamo Calo, David G. Lambert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316f1aec76a8fa1c191adf9c25cbd62
https://hdl.handle.net/11577/3479489
https://hdl.handle.net/11577/3479489
Autor:
Christopher P. Hebbes
Publikováno v:
Anaesthesia & Intensive Care Medicine. 19:648-655
Inadequate end organ perfusion and tissue hypoxia is an end point of many disease processes in critical illness. Maintenance of blood flow and hence tissue oxygenation is critical to the management of intensive care patients. End organ blood flow is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e3f91822a01082d6ba4bbe16337063
https://doi.org/10.1016/j.mpaic.2018.09.003
https://doi.org/10.1016/j.mpaic.2018.09.003
Autor:
Zoë L S Brookes, Emily N Stedman, Nicola J Brown, Christopher P Hebbes, Remo Guerrini, Girolamo Calo, Charles S Reilly, David G Lambert
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74943 (2013)
Microvascular inflammation occurs during sepsis and the endogenous opioid-like peptide nociceptin/orphanin FQ (N/OFQ) is known to regulate inflammation. This study aimed to determine the inflammatory role of N/OFQ and its receptor NOP (ORL1) within t
Externí odkaz:
https://doaj.org/article/3e7a56646f904c4a90c62a4b19a28542
Publikováno v:
Anaesthesia & Intensive Care Medicine. 9:79-83
Pain is a major cause of distress, both physical and psychological and is also associated with increased inpatient hospital stays, poor wound healing and prolonged rehabilitation. Opioids are a mainstay of treatment for acute pain, although they are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5145a21134a2cf1b155eaf41340729dd
https://doi.org/10.1016/j.mpaic.2007.11.012
https://doi.org/10.1016/j.mpaic.2007.11.012
Autor:
Barbara Spagnolo, Elaine C. Gavioli, Raffaella Vergura, David G. Lambert, Elena Valenti, Gianfranco Balboni, John McDonald, Severo Salvadori, Christopher P. Hebbes, Domenico Regoli, Girolamo Calo
Knockout and pharmacological studies demonstrated that the activation of delta opioid peptide (DOP) receptors produces antidepressant-like effects in rodents. Here we report the results obtained with the novel DOP ligand H-Dmt-Tic-NH-CH 2 -Bid (UFP-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388749d3e3d4ea64305135e9967c6679
http://hdl.handle.net/11577/3386443
http://hdl.handle.net/11577/3386443
Autor:
Severo Salvadori, Samantha Rubini, Christopher P. Hebbes, Remo Guerrini, Claudio Trapella, Domenico Regoli, Giulia Fanton, David G. Lambert, Girolamo Calo, Barbara Spagnolo, Giacomo Carrà, John McDonald, Laura Piccagli
To date, J-113397 represents the most potent and selective non peptide NOP receptor antagonist widely used in pharmacological studies. However, the synthesis, purification, and enantiomer separation of this molecule, which contains two chiral centers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c36c3fa3f32bb653647a8af7a57590
http://hdl.handle.net/11577/3386454
http://hdl.handle.net/11577/3386454
Autor:
Remo Guerrini, David G. Lambert, Severo Salvadori, Michele Morari, John McDonald, Elaine C. Gavioli, Silvia Zucchini, David J. Rowbotham, Giuliano Marzola, Daniel R. Kapusta, Velga A. Kenigs, Domenico Regoli, Daniela Rizzi, T. A. Barnes, Anna Rizzi, Giacomo Carrà, Girolamo Calo, Flora Mela, Christopher P. Hebbes
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 312(3)
A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86c667878c4e7439fb28c8f867b8d5d
https://pubmed.ncbi.nlm.nih.gov/15509719
https://pubmed.ncbi.nlm.nih.gov/15509719
Autor:
Emily N. Stedman, Nicola J. Brown, Remo Guerrini, Charles S. Reilly, Zoë L. S. Brookes, Christopher P. Hebbes, David G. Lambert, Girolamo Calo
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74943 (2013)
PLoS ONE
PLoS ONE
Microvascular inflammation occurs during sepsis and the endogenous opioid-like peptide nociceptin/orphanin FQ (N/OFQ) is known to regulate inflammation. This study aimed to determine the inflammatory role of N/OFQ and its receptor NOP (ORL1) within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5480438a0a44f3ae8cbb318e80f1b5
https://doi.org/10.1371/journal.pone.0074943
https://doi.org/10.1371/journal.pone.0074943