Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Christopher P. Ford"'
Autor:
Marie A. Labouesse, Maria Wilhelm, Zacharoula Kagiampaki, Andrew G. Yee, Raphaelle Denis, Masaya Harada, Andrea Gresch, Alina-Măriuca Marinescu, Kanako Otomo, Sebastiano Curreli, Laia Serratosa Capdevila, Xuehan Zhou, Reto B. Cola, Luca Ravotto, Chaim Glück, Stanislav Cherepanov, Bruno Weber, Xin Zhou, Jason Katner, Kjell A. Svensson, Tommaso Fellin, Louis-Eric Trudeau, Christopher P. Ford, Yaroslav Sych, Tommaso Patriarchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release, but their ability to detect a wide range of extracellular DA levels, especially tonic versus phasic DA release, is limited by their intrinsic affinity. H
Externí odkaz:
https://doaj.org/article/edad0bcf8205400a8af1560d0567e9ed
Autor:
Sarah M. Zych, Christopher P. Ford
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110823- (2022)
Summary: Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major in
Externí odkaz:
https://doaj.org/article/697fb1a9ffbb4a3b92c79fdb1e5cf23c
Autor:
Giuseppe Giannotti, Sheng Gong, Nicholas Fayette, Jasper A. Heinsbroek, James E. Orfila, Paco S. Herson, Christopher P. Ford, Jamie Peters
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109605- (2021)
Summary: Here, we use optogenetics and chemogenetics to investigate the contribution of the paraventricular thalamus (PVT) to nucleus accumbens (NAc) pathway in aversion and heroin relapse in two different heroin self-administration models in rats. I
Externí odkaz:
https://doaj.org/article/871e82e44d15409d9fd6859a44b79a3a
Autor:
Sahil Gulati, Hui Jin, Ikuo Masuho, Tivadar Orban, Yuan Cai, Els Pardon, Kirill A. Martemyanov, Philip D. Kiser, Phoebe L. Stewart, Christopher P. Ford, Jan Steyaert, Krzysztof Palczewski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
G protein-coupled receptors (GPCRs) activate and dissociate the G protein heterotrimer into Gα-GTP and Gβγ dimer, which facilitate distinct signalling events. Here authors develop a nanobody, Nb5 that modulates Gβγ-mediated signaling without aff
Externí odkaz:
https://doaj.org/article/97d5df502176477f968bd4bc5a4ab8fb
Autor:
Bernard Mulvey, Dionnet L. Bhatti, Sandeep Gyawali, Allison M. Lake, Skirmantas Kriaucionis, Christopher P. Ford, Michael R. Bruchas, Nathaniel Heintz, Joseph D. Dougherty
Publikováno v:
Cell Reports, Vol 23, Iss 8, Pp 2225-2235 (2018)
Summary: Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders. Such disorders are often treated by drugs targeting the CNS norepinephrine system. D
Externí odkaz:
https://doaj.org/article/6ac7b9b9e28846d1b81cff59a75d5614
Autor:
Yuan Cai, Christopher P. Ford
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3148-3157.e3 (2018)
Summary: The balance of dopamine and acetylcholine in the dorsal striatum is critical for motor and learning functions. Midbrain dopamine cells and local cholinergic interneurons (ChIs) densely innervate the striatum and have strong reciprocal action
Externí odkaz:
https://doaj.org/article/372a380e286d463cb6903c20fe35d1f1
Autor:
Dayana Rodriguez-Contreras, Sheng Gong, Joseph J. Lebowitz, Lev M. Fedorov, Naeem Asad, Timothy M. Dore, Tamara J. Phillips, Christopher P. Ford, John T. Williams, Kim A. Neve
Publikováno v:
Molecular Pharmacology. 103:188-198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53ba8a989624b84222f557b312613ac0
https://doi.org/10.1124/molpharm.122.000606
https://doi.org/10.1124/molpharm.122.000606
Autor:
Andrew T. Luskin, Li Li, Xiaonan Fu, Kelsey Barcomb, Taylor Blackburn, Esther M. Li, Akshay Rana, Rhiana C. Simon, Li Sun, Alexandria D. Murry, Sam A. Golden, Garret D. Stuber, Christopher P. Ford, Liangcai Gu, Michael R. Bruchas
As the primary source of norepinephrine (NE) in the brain, the locus coeruleus (LC) regulates both arousal and stress responses1,2. However, how local neuromodulatory inputs contribute to LC function remains unresolved. Here we identify a network of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faeb18f77f390609a7b3459ed3949459
https://doi.org/10.1101/2022.06.30.498327
https://doi.org/10.1101/2022.06.30.498327
Autor:
Dayana Rodriguez-Contreras, Sheng Gong, Joseph J Lebowitz, Lev M Fedorov, Naeem Asad, Timothy M Dore, Christopher P Ford, John T Williams, Kim A Neve
A dopamine D2 receptor mutation was recently identified in a family with a novel hyperkinetic movement disorder (Mov Disord 36: 729-739, 2021). That allelic variant D2-I212F is a constitutively active and G protein-biased receptor. We now describe mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5def031ef553f2918860cf041b0b1bf1
https://doi.org/10.1101/2022.06.09.495548
https://doi.org/10.1101/2022.06.09.495548
Autor:
Sarah M. Zych, Christopher P. Ford
Publikováno v:
Cell reports. 39(7)
Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc5b153a22518d9769342c0d598e0fb
https://pubmed.ncbi.nlm.nih.gov/35584679
https://pubmed.ncbi.nlm.nih.gov/35584679