Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christopher P. Ashcroft"'
Autor:
Cameron Abercrombie, Christopher P. Ashcroft, Matthew Badland, Aaron Baldwin, Livia T. Baldwin, Sarah Brisley, Wayne Callar, Pedro Daddario, Elaa Hilou, Chintelle James, Ruizhi Li, Yiyang Liu, Sebastien Monfette, Jared L. Piper, Giselle Reyes, Hud Risley, Fabrice H. Salingue, Kudzai Saunyama, Michael G. Vetelino
Publikováno v:
Organic Process Research & Development. 27:866-874
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e0736e520493081cfb2cbdddafe2822
https://doi.org/10.1021/acs.oprd.3c00038
https://doi.org/10.1021/acs.oprd.3c00038
Autor:
Huiling Shao, Jose M. Medina, Ryan T. Helsel, Peng Liu, Joseph Derosa, Indrawan James Mcalpine, John F. Braganza, Tuğçe G. Erbay, Christopher P. Ashcroft, Gary M. Gallego, Shouliang Yang, Paul F. Richardson, Ryan L. Patman, Keary M. Engle, Fen Wang, Taeho Kang, Michelle Tran-Dubé
Publikováno v:
ACS Catal
The copper-catalyzed hydroboration of benzylidenecyclopropanes, conveniently accessed in one step from readily available benzaldehydes, is reported. Under otherwise identical reaction conditions, two distinct phosphine ligands grant access to differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4e3f4d66a75d1c1eab647eda2e78b1
https://doi.org/10.26434/chemrxiv.8341016.v1
https://doi.org/10.26434/chemrxiv.8341016.v1
Publikováno v:
Organic Process Research & Development. 19:740-747
A survey of solvent usage for papers published in Organic Process Research & Development has been carried out for the years 1997–2012. Three solvent categories were studied: (i) solvents of concern, (ii) dipolar aprotic solvents, and (iii) neoteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56343316d4f6459a26e9e5eb9774b468
https://doi.org/10.1021/op500276u
https://doi.org/10.1021/op500276u
Publikováno v:
Tetrahedron Letters. 54:4529-4532
The Suzuki cross-coupling between 2-(4-bromophenyl)-5-chloropyrazine and a range of aryl boronic acids has been investigated. The regioselectivity of the reaction can be switched between the aryl bromide and pyrazinyl chloride positions by changing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceae1064a5af1179ff6ee654e529e218
https://doi.org/10.1016/j.tetlet.2013.06.068
https://doi.org/10.1016/j.tetlet.2013.06.068
Autor:
Smith Julian Duncan, David A. Entwistle, Christopher P. Ashcroft, Yann Dessi, Adrian Longstaff, Lynsey C. Hesmondhalgh
Publikováno v:
Organic Process Research & Development. 16:470-483
This article describes the selection, process development, and scale-up of a synthetic route to a complex nucleoside analogue, the A2a agonist UK-432,097 (1), that culminated in the manufacture of over 25 kg of the API. The key steps in the process w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21b0a30f99a64351406f69ace4beaf2a
https://doi.org/10.1021/op200365n
https://doi.org/10.1021/op200365n
Autor:
David Clifford, John R. Williams, Terry V. Silk, Christopher P. Ashcroft, Nicholas Murray Thomson, Yousef Hajikarimian, Andrew Derrick, Keith Slucock, Stephen Challenger
Publikováno v:
Organic Process Research & Development. 9:663-669
The development and scale-up of a potential manufacturing route to the endothelin antagonists UK-350,926 1 and UK-349,862 2 are described. A key synthetic challenge in designing an efficient route ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b28966a20dd48524c7fffef95182190
https://doi.org/10.1021/op050102f
https://doi.org/10.1021/op050102f
Autor:
Stephen Challenger, Nicholas Murray Thomson, Richard Storey, Andrew Derrick, Christopher P. Ashcroft
Publikováno v:
Organic Process Research & Development. 7:362-368
An efficient and practical synthesis is presented of the pharmaceutically active MMP-3 inhibitor UK-370,106 (1) via an olefination/catalytic asymmetric hydrogenation sequence. Commercially available 5-bromo-2-iodotoluene was converted in two steps to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430871353b5335fb998509405cb56a50
https://doi.org/10.1021/op034001y
https://doi.org/10.1021/op034001y
Publikováno v:
ChemInform. 44
The Suzuki cross-coupling between 2-(4-bromophenyl)-5-chloropyrazine (I) and a range of aryl boronic acids is investigated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::218ed25512bef3835b28c66d37b469df
https://doi.org/10.1002/chin.201351186
https://doi.org/10.1002/chin.201351186
Autor:
Nicholas Murray Thomson, Stephen Challenger, Yousef Hajikarimian, Christopher P. Ashcroft, Andrew Derrick
Publikováno v:
Process Chemistry in the Pharmaceutical Industry, Volume 2: Challenges in an Ever Changing Climate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c2f27f5f209797a2eaf5a8372451bc7
https://doi.org/10.1201/9781420008357.ch10
https://doi.org/10.1201/9781420008357.ch10